I noticed some similarities between wumedical's anecdotal SCI neural stem cell treatment case, Asteria's prelim cervical AST-OPC1 reports and reports about use of 4-AP (4-Aminopyridine), a potassium channel blocker. They all appear to target demyelinated axons with poor conduction, a consequence of SCI. Asteria even mentions the target of their AST-OPC1 stem cells is demyelinated axons.
So I got 4-AP compounded and tested it at 10mg x 4 times a day dose (later went down to 5mg 4x a day due to nausea), after which, as a C4-incomplete I noticed:
- greatly reduced spasticity allowing noticably faster heel-to-toe walking
- sweating for the first time down my back -> a marked improvement in sensation
- increased firmess through the core
- better hand dexterity and alleviation of shoulder tightness/pain
These are similar benefits to what wumedical stories say.
I've then concluded then that anybody contemplating stem cell therapy should consider trying 4-AP first to gauge how much remyelination potential exists, along with functional gains obtained. 4-AP is a lot cheaper than say the US$25k Wumedical stem cell therapy though of course when you're not on it, the benefit is gone.
Asteria's AST-OPC1 stem cell treatment above and below the injury site is about as good as it gets. Though that's still at a clinical trial phase .
4-AP or even better 4-AP-3-MeOH support references
Where to buy 4-AP or the even better 4-AP-3-MeOH?
4-AP is available from your local compounding pharmacy with a prescription. Looking at 5mg every 2-4 hours dosage. I found 10mg in such doses caused nausea. In Australia, I was paying AU$100 for 100 tablets. A bit expensive for what used to be a bird repellent, so I found a significantly cheaper source that even stocks the better 4-AP-3-MeOH, though that form costs 3.33 times more than 4-AP.
I'm yet to try 4-AP-3-MeOH but the "requires 1/10 dose of 4-AP" literature of Dr. Shi is attracting me to do so.