Both 4-AP and stem cell treatment target demyelinated axons for better CNS conduction

[Pauly1]

I noticed some similarities between wumedical's anecdotal SCI neural stem cell treatment case, Asteria's prelim cervical AST-OPC1 reports and reports about use of 4-AP (4-Aminopyridine), a potassium channel blocker. They all appear to target demyelinated axons with poor conduction, a consequence of SCI. Asteria even mentions the target of their AST-OPC1 stem cells is demyelinated axons.

So I got 4-AP compounded and tested it at 10mg x 4 times a day dose (later went down to 5mg 4x a day due to nausea), after which, as a C4-incomplete I noticed:

- greatly reduced spasticity allowing noticably faster heel-to-toe walking
- sweating for the first time down my back -> a marked improvement in sensation
- increased firmess through the core
- better hand dexterity and alleviation of shoulder tightness/pain

These are similar benefits to what wumedical stories say.

I've then concluded then that anybody contemplating stem cell therapy should consider trying 4-AP first to gauge how much remyelination potential exists, along with functional gains obtained. 4-AP is a lot cheaper than say the US$25k Wumedical stem cell therapy though of course when you're not on it, the benefit is gone.

Asteria's AST-OPC1 stem cell treatment above and below the injury site is about as good as it gets. Though that's still at a clinical trial phase .


4-AP or even better 4-AP-3-MeOH support references

SCI

http://www.sci-therapies.info/Pharm-Chronic.htm#4AP
http://sci.rutgers.edu/forum/showthr...CI-Dr-Riyi-Shi
https://miracleofwalk.wordpress.com/2015/09/28/my-testing-of-4ap-3-meoh/


AMN/MS

http://www.mult-sclerosis.org/news/May2000/4APFAQ.html
https://healthunlocked.com/amneasier...nosed-with-amn
https://healthunlocked.com/amneasier/posts/133633198/4-ap-anyone-tried-it
https://healthunlocked.com/amneasier/posts/131982109/4-aminopyridine-3-methanol-4-ap-3-meoh-.


Where to buy 4-AP or the even better 4-AP-3-MeOH?

4-AP is available from your local compounding pharmacy with a prescription. Looking at 5mg every 2-4 hours dosage. I found 10mg in such doses caused nausea. In Australia, I was paying AU$100 for 100 tablets. A bit expensive for what used to be a bird repellent, so I found a significantly cheaper source that even stocks the better 4-AP-3-MeOH, though that form costs 3.33 times more than 4-AP.

https://www.mod4all.com/zencart/index.php?main_page=index&cPath=2

I'm yet to try 4-AP-3-MeOH but the "requires 1/10 dose of 4-AP" literature of Dr. Shi is attracting me to do so.

[matt414]

https://www.ncbi.nlm.nih.gov/pubmed/27861125

Came across that a week or two ago. I've been taking 4-ap for about two years now. I have a high level of function, full time walking, semi professional cyclist, after being diagnosed as a complete injury 13 years ago. In theory, I'd thought that 4-ap would possible cause mylein to regrow, slow rate, but would be possible. What I've seen in my recovery tells me it has happened.

[alhavel]

I took Ampyra for 3 years, then I had a spinal stimulator surgically installed. I let the prescription run out (wrong) and I have some older stuff here that I had compounded a while ago. My best walking was with the 4-AP and the stimulator. I decided do to the cost to just used the stimulator, lately I have been turning it down more and more. I feel it if it isn?t even on, it?s been a year since I had this done. I am going to get back on the 4-AP and see what?s going on now. As of now, I can feel the cold breeze on my ankle from time to time and things are just generally weird, going to go back to San Diego where I had it done for a tune up, as I know what and where I need more function, it?s been just a bad and hectic year for me on other sides, and now I have a plan. Plus I found out I have gout, and no valves in my internal blood veins so I have this wonderful water problem, the key is to keep moving at all costs, and I'm no spring chicken, stubborn to say the least.

[GRAMMY]

https://www.ncbi.nlm.nih.gov/pubmed/27861125

Came across that a week or two ago. I've been taking 4-ap for about two years now. I have a high level of function, full time walking, semi professional cyclist, after being diagnosed as a complete injury 13 years ago. In theory, I'd thought that 4-ap would possible cause mylein to regrow, slow rate, but would be possible. What I've seen in my recovery tells me it has happened.

You've come a long way since you posted this years ago. LINK

Here's the full publication link instead of the abstract on the mice treated beginning at 24 hours post injury for their peripheral nerve injury.

[GRAMMY]

I took Ampyra for 3 years, then I had a spinal stimulator surgically installed. I let the prescription run out (wrong) and I have some older stuff here that I had compounded a while ago. My best walking was with the 4-AP and the stimulator. I decided do to the cost to just used the stimulator, lately I have been turning it down more and more. I feel it if it isn?t even on, it?s been a year since I had this done. I am going to get back on the 4-AP and see what?s going on now. As of now, I can feel the cold breeze on my ankle from time to time and things are just generally weird, going to go back to San Diego where I had it done for a tune up, as I know what and where I need more function, it?s been just a bad and hectic year for me on other sides, and now I have a plan. Plus I found out I have gout, and no valves in my internal blood veins so I have this wonderful water problem, the key is to keep moving at all costs, and I'm no spring chicken, stubborn to say the least.

Glad to hear you're staying with the program and still working forward. Best of luck on your return trip to San Diego!

[matt414]

Thanks! I have. It's been a VERY long road. I've explored pretty much every road out there. I am still chasing what most would call a "cure", for me nothing is enough. Which I've often called a curse and a blessing. it's what has gotten me this far, but keeps me up most nights.

[alhavel]

You?re are right. I have done the same, and i have
been able to progress so far, but it's not enough, I want more, a reversal of time so to speak.

[Wills77]

I'm interested in trying this out. Do you take baclofen?

[Sparky831]

Will this work for Chronic Complete SCI?

[GRAMMY]

There are lots of 4-AP threads here at the forum where people have talked about their results. Just type 4-AP in the search box to access them.