New, In Mexico

[lunasicc42]

Thanks Pauly

[GRAMMY]

Rather than rat studies, you're looking for the publication and data on the 45 treated patients.

[Pauly1]

@fti or and admin, would you mind changing the thread title to be more informative that summarizes the important info in this thread? eg:

Mexico: Leuprolide acetate injections see up to 40% SCI recovery

[lunasicc42]

Rather than rat studies, you're looking for the publication and data on the 45 treated patients.

Do you have access to it?

[GRAMMY]

Do you have access to it?

I don't know that one actually even exists.

[Mize]

@fti or and admin, would you mind changing the thread title to be more informative that summarizes the important info in this thread? eg:

Mexico: Leuprolide acetate injections see up to 40% SCI recovery

Be nice if we could ascertain what 40% improvement means.

[GRAMMY]

Nowhere does the article describe the injections. I assume they are into the cord.

Leuprolide acetate is known to break the blood brain barrier, it can be administered intermuscular - subcutaneous or depot. It wouldn't have to be injected directly into the cord. Several companies market it under different brand names for various conditions.

Be nice if we could ascertain what 40% improvement means.

Here's the Basso, Beattie and Bresnahan (BBB) locomotor scale method explanation: http://pages.jh.edu/SCI/characterization/bbb.shtml

This is the charted results for the rat study total of 5 weeks.

http://www.nrronline.org/viewimage.asp?img=NeuralRegenRes_2015_10_11_1819_1 70311_f1.jpg

I believe it shows the LA group data at 8 which is sweeping with no weight. Basically the rat can flex and extend while laying on it's side but doesn't support weight. Usually on day one of surgery they rate 0, but rats do slowly recover naturally from a SCI. Here's a good explanation by Jerry Silver on how the BBB scale is used towards viewing translational therapies. He was talking more about NY Impactor vs. the Infinite Horizon rather than a baloon style compression (which is rarely used in a US SCI lab), but the discussion is still valid. LINK

At the 5^th week, leuprolide acetate-treated rats showed locomotor activity recovery by 38%, had improvement in kinematic gait and exhibited voiding reflex recovery by 60%, as compared with the 1^st week. By contrast, saline solution-treated rats showed locomotor activity recovery only by 7%, but voiding reflex did not recover.


In other words, a 5 week natural rat recovery to 8 isn't that remarkable.

[Pauly1]

Here's an english link not posted yet:

A Drug Used For Cancer Causes Notable Improvements in Patients with Spinal Cord Injuries
http://www.salud.carlosslim.org/english2/a-drug-used-for-cancer-causes-notable-improvements-in-patients-with-spinal-cord-injuries/

A group of 45 patients who received an injection of leuprolide acetate each month have experienced improvements in body movement, sphincter muscles control and partial recovery of sensation in their extremities.


The results showed that the recovery rate is variable, depending on several factors like injury’s magnitude, level and time elapsed since it was suffered. On average, it was recorded a 40 regeneration in the group of patients, and the effects are permanent.
...
They chose candidates in people with spinal cord injury with certain characteristics; for example, all of them suffered their injuries from one to five years. All patients showed an improvement, which varied depending on the type of injury, its location, its magnitude, and time since it was suffered. Some patients were able to walk again, patients who did not control their sphincter muscles were able to control them, and kids with practically total paralysis could move their legs, Quintanar Stephano said

[GRAMMY]

Here's an english link not posted yet:
A Drug Used For Cancer Causes Notable Improvements in Patients with Spinal Cord Injuries
http://www.salud.carlosslim.org/engl...cord-injuries/

That's the news article Chilacas translated a few days ago put out from the Carlos Slim Foundation but nobody has found a scientific publication about human testing.

Here's a list of the other SCI treatments they've posted about.

I wouldn't get too excited about a repurposed drug news article until we can see some human trial data and know what extent of SCI was involved.

[Mize]

Thanks, once again, Grammy. You always come through.

So it appears that 40% recovery means getting back to 40% of normal function. That's truly impressive if reproducible.