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Thread: Scientists have figured out how to help nerve fibres repair themselves

  1. #1

    Scientists have figured out how to help nerve fibres repair themselves

    Scientists have figured out how to make nerve fibres repair themselves in mice, having identified a gene that inhibits fibre regrowth when nerve connections become damaged.
    This gene, called Cacna2d2, acts as 'molecular brake', but now that we know how to turn the brake off, it could help us to develop treatments for conditions like paralysis and other spinal cord injuries.

    ...

    http://www.sciencealert.com/this-new...air-themselves

  2. #2
    Senior Member lunasicc42's Avatar
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    so would I be correct in Assuming that this is for very Acute injuries before any scar forms because it doesn't mention that
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    Senior Member lynnifer's Avatar
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    This sounds familiar to what Dr Silver was working on (if you listened to his videos).
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  4. #4
    Quote Originally Posted by lunasicc42 View Post
    so would I be correct in Assuming that this is for very Acute injuries before any scar forms because it doesn't mention that
    I think it's too early to know the capability of Pregabalin until further testing is done.

    Cacna2d2 encodes the blueprint of a protein that is part of a larger molecular complex. The protein anchors ion channels in the cell membrane that regulate the flow of calcium particles into the cell. Calcium levels affect cellular processes such as the release of neurotransmitters. These ion channels are therefore essential for the communication between neurons.

    In further investigations, the researchers used Pregabalin (PGB), a drug that had long been known to bind to the molecular anchors of calcium channels. Over a period of several weeks, they administered PGB to mice with spinal cord injuries. As it turned out, this treatment caused new nerve connections to grow.

    Our study shows that synapse formation acts as a powerful switch that restrains axonal growth. A clinically-relevant drug can manipulate this effect, says Bradke. In fact, PGB is already being used to treat lesions of the spinal cord, albeit it is applied as a pain killer and relatively late after the injury has occurred. PGB might have a regenerative effect in patients, if it is given soon enough. In the long term this could lead to a new treatment approach. However, we don't know yet."

    In previous studies, the DZNE researchers showed that certain cancer drugs can also cause damaged nerve connections to regrow. The main protagonists in this process are the microtubules, long protein complexes that stabilize the cell body. When the microtubules grow, axons do as well. Is there a connection between the different findings? We don't know whether these mechanisms are independent or whether they are somehow related, says Bradke. This is something we want to examine more closely in the future.

    LINK

  5. #5
    Senior Member lunasicc42's Avatar
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    OK makes sense ...needs further research concerning chronic



    Quote Originally Posted by GRAMMY View Post
    I think it's too early to know the capability of Pregabalin until further testing is done.

    Cacna2d2 encodes the blueprint of a protein that is part of a larger molecular complex. The protein anchors ion channels in the cell membrane that regulate the flow of calcium particles into the cell. Calcium levels affect cellular processes such as the release of neurotransmitters. These ion channels are therefore essential for the communication between neurons.

    In further investigations, the researchers used Pregabalin (PGB), a drug that had long been known to bind to the molecular anchors of calcium channels. Over a period of several weeks, they administered PGB to mice with spinal cord injuries. As it turned out, this treatment caused new nerve connections to grow.

    Our study shows that synapse formation acts as a powerful switch that restrains axonal growth. A clinically-relevant drug can manipulate this effect, says Bradke. In fact, PGB is already being used to treat lesions of the spinal cord, albeit it is applied as a pain killer and relatively late after the injury has occurred. PGB might have a regenerative effect in patients, if it is given soon enough. In the long term this could lead to a new treatment approach. However, we don't know yet."

    In previous studies, the DZNE researchers showed that certain cancer drugs can also cause damaged nerve connections to regrow. The main protagonists in this process are the microtubules, long protein complexes that stabilize the cell body. When the microtubules grow, axons do as well. Is there a connection between the different findings? We don't know whether these mechanisms are independent or whether they are somehow related, says Bradke. This is something we want to examine more closely in the future.

    LINK
    "That's not smog! It's SMUG!! " - randy marsh, southpark

    "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


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