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Thread: Phages for Multi-drug Resistant UTI

  1. #1
    Senior Member Jeff's Avatar
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    Phages for Multi-drug Resistant UTI

    Hi folks. It's been a while.


    Re-introduction: C6, nearly complete, injured in 1980. Been living in the Philippines for around ten years.


    I've been having 2 or 3 UTIs per year for 36 years. I did have a multi-year hiatus in there, somewhere, using methenamine.


    Long story short, I'm colonized with e. coli resistant to everything except gentamicin, chloramphenicol and carbapenems. Yikes!!


    I'm saving carbapenems in case of emergency, like sepsis. Gentamicin is hard on the kidneys and chloramphenicol is a real killer.


    So, I ordered phages from http://www.phagetherapycenter.com . They arrived yesterday, afternoon. After only two doses my urine is clearing up, already.


    I had been going through hell, thought I would be dead in a year or two for sure.


    Now, I feel alive!!


    If you're running out of options or even just running out of oral options then begin studying bacteriophages. You'll be glad you did!
    ~See you at the CareCure-used-to-be-paralyzed Reunion ~

  2. #2
    Quote Originally Posted by Jeff View Post
    So, I ordered phages from http://www.phagetherapycenter.com . They arrived yesterday, afternoon. After only two doses my urine is clearing up, already.
    When you say you "ordered phages," what does that mean? You became a patient and are going through the blood tests or they have actual products that you order. I didn't notice a products page at the site provided.

    All the best,
    GJ

  3. #3
    Gentamicin instillations into the bladder would be perfect for you. Instillations are not absorbed by the body, so no kidney side effects. And doing them regularly, low dose seems to keep away the UTIs. My Dad's neuro-urologist (who is a SCI specialist) has not had trouble with her patients developing Gentamicin resistant UTIs while using them. It is an option she saves for patients who are having a lot of UTIs, that are becoming increasingly resistant to antibiotics.

    It broke a bad cycle of 7 UTIs in a row for my Dad.

    Curious ... so you are injecting a mixture of bacteriophages (= viruses that like to infect bacteria, and then cause the bacteria to die) into your bladder? Has any doctor recommended trying this? I must admit, I am a bit wary about therapies originating in the country of Georgia...

    How much does it cost?
    Last edited by hlh; 09-24-2016 at 11:05 AM.

  4. #4
    Doubt you can purchase or import this into the USA (Jeff is in the Philippines (in spite of what his profile says) as not FDA approved. Here is an article about some research being done on phage therapy for drug resistant infections (MRSA in this case):
    http://www.sandiegouniontribune.com/...913-story.html

    (KLD)

  5. #5
    Senior Member Jeff's Avatar
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    I was unable to send a urine sample to them. No courier here would accept it. So, I asked them to give me everything they had for E Coli. Instead, they just sent me IntestiPhage and PyoPhage. These are pre-packaged cocktails with several phages each for a variety of pathogens. Each package contains 5 vials 20ml for $45. They sent me 7 packages of both kinds. The total for phages was $630, shipping and handling - $250, and a 2.9% fee for using a credit card. Once my package arrived at customs, there were FedEx extra fees for customs clearance - $150 and Philippines taxes and duty - $50.

    The fluid is taken orally, twice a day. I first take ranitidine to slow production of stomach acid. Drink water while I wait 20 minutes. Then pop a sodium bicarb and munch a tums. After which I suck down my two phage preparations. It's not required but this should help more phages survive the trip through the stomach.

    Americans are importing phages all the time, with low but varying degrees of red tape.

    https://www.buzzfeed.com/azeenghoray...Rr#.ml50ea8Yby
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    ~See you at the CareCure-used-to-be-paralyzed Reunion ~

  6. #6
    Thanks for sharing this. I had no idea.

    Keep us posted on how you feel, and how it goes.

  7. #7
    Senior Member Jeff's Avatar
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    hlh,

    I'm actually not out of the woods, yet. I've been carrying this same strain of e coli for a few years. I've only treated it when it spread beyond my bladder into kidney or epididymis. Antibiotics would resolve the problem but then the same strain would always relapse immediately. And my next culture/sensitivity would be one option fewer. I began to have anxiety.

    A CT-Stonogram showed prostate stones. So, I figured the bugs were either hiding out in prostate stones or biofilm. Either way, phages are better at killing them off than antibiotics.

    I'm also studying theories about resistance that cite persister cells. Protocols are being developed for staggering treatment to allow bacteria to come out of hiding. I might try it this time with my phages.
    ~See you at the CareCure-used-to-be-paralyzed Reunion ~

  8. #8
    Quote Originally Posted by Jeff View Post
    hlh,

    I'm actually not out of the woods, yet. I've been carrying this same strain of e coli for a few years. I've only treated it when it spread beyond my bladder into kidney or epididymis. Antibiotics would resolve the problem but then the same strain would always relapse immediately. And my next culture/sensitivity would be one option fewer. I began to have anxiety.

    A CT-Stonogram showed prostate stones. So, I figured the bugs were either hiding out in prostate stones or biofilm. Either way, phages are better at killing them off than antibiotics.

    I'm also studying theories about resistance that cite persister cells. Protocols are being developed for staggering treatment to allow bacteria to come out of hiding. I might try it this time with my phages.
    Since your issue with colonization/infection is e coli, have you tried D-Mannose?

    All the best,
    GJ

  9. #9
    Senior Member Jeff's Avatar
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    Yeah, I took enough d-mannose to choke a goat. I bought it by the kilo from http://purebulk.com . I would mix two heaping tbsp in a glass of water. No help.

    Olive leaf extract really cleared up my urine but therapeutic doses gave me lethal diarrhea. I took it with turmeric. Had to quit.

    Later, I discovered that tumeric alone would reduce the sludge factor by 90%. Wouldn't kill the infection, though.

    Coconut is big here, along with a hundred other herbal treatments and Chinese medicine. None of it helped me.
    ~See you at the CareCure-used-to-be-paralyzed Reunion ~

  10. #10
    good info jeff.
    did you stop the methenamine or did it stop working
    Bike-on.com rep
    John@bike-on.com
    c4/5 inc funtioning c6. 28 yrs post.
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