Results 1 to 2 of 2

Thread: Alzheimer disease research in the 21st century

  1. #1

    Alzheimer disease research in the 21st century

    Oncotarget. 2016 May 4. doi: 10.18632/oncotarget.9175. [Epub ahead of print]

    Alzheimer disease research in the 21st century: past and current failures, new perspectives and funding priorities.

    Pistollato F1, Ohayon EL2, Lam A1,2, Langley GR3, Novak TJ4, Pamies D5, Perry G6, Trushina E7, Williams RS8, Roher AE9,10, Hartung T5, Harnad S11, Barnard N1, Morris MC12, Lai MC1, Merkley R1, Chandrasekera PC1.

    Author information


    Much of Alzheimer disease (AD) research has been traditionally based on the use of animals, which have been extensively applied in an effort to both improve our understanding of the pathophysiological mechanisms of the disease and to test novel therapeutic approaches. However, decades of such research have not effectively translated into substantial therapeutic success for human patients. Here we critically discuss these issues in order to determine how existing human-based methods can be applied to study AD pathology and develop novel therapeutics. These methods, which include patient-derived cells, computational analysis and models, together with large-scale epidemiological studies represent novel and exciting tools to enhance and forward AD research. In particular, these methods are helping advance AD research by contributing multifactorial and multidimensional perspectives, especially considering the crucial role played by lifestyle risk factors in the determination of AD risk. In addition to research techniques, we also consider related pitfalls and flaws in the current research funding system. Conversely, we identify encouraging new trends in research and government policy. In light of these new research directions, we provide recommendations regarding prioritization of research funding. The goal of this document is to stimulate scientific and public discussion on the need to explore new avenues in AD research, considering outcome and ethics as core principles to reliably judge traditional research efforts and eventually undertake new research strategies.
    “As the cast of villains in SCI is vast and collaborative, so too must be the chorus of hero's that rise to meet them” Ramer et al 2005

  2. #2
    This is a great read for anyone interested in AD!

    Thank you for sharing

Similar Threads

  1. 21st Century Cures
    By paolocipolla in forum Funding, Legislation, & Advocacy
    Replies: 16
    Last Post: 06-14-2015, 12:44 PM
  2. 21st Century Snake Oil
    By Wise Young in forum Cure
    Replies: 17
    Last Post: 06-07-2010, 04:46 PM
  3. 21st Century Battlecarriers
    By Mike C in forum Science, Medicine, & Technology
    Replies: 4
    Last Post: 06-11-2007, 08:28 PM
  4. 21st century bounder
    By Leo in forum Equipment
    Replies: 0
    Last Post: 12-02-2004, 01:44 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts