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Thread: Scientists Find That Stem Cells in the Bone Marrow Become Liver Cells

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    Scientists Find That Stem Cells in the Bone Marrow Become Liver Cells

    Scientists Find That Stem Cells in the Bone Marrow Become Liver Cells
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    WEIZMANN INSTITUTE SCIENTISTS FIND THAT STEM CELLS IN THE BONE MARROW BECOME LIVER CELLS
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    Stem cells in our bone marrow usually develop into blood cells, replenishing our blood system. However, in states of emergency, the destiny of some of these stem cells may change: They can become virtually any type of cell - liver cells, muscle cells, nerve cells - responding to the body's needs.



    Newswise-They still don't have a personality, and they're waiting for the maturity call. Stem cells in our bone marrow usually develop into blood cells, replenishing our blood system. However, in states of emergency, the destiny of some of these stem cells may change: They can become virtually any type of cell - liver cells, muscle cells, nerve cells - responding to the body's needs.

    Prof. Tsvee Lapidot and Dr. Orit Kollet of the Weizmann Institute's Immunology Department have found how the liver, when damaged, sends a cry for help to these stem cells. "When the liver becomes damaged, it signals to stem cells in the bone marrow, which rush to it and help in its repair - as liver cells," says Lapidot. His research team has found that certain molecules that govern normal development of the liver become overproduced when it is damaged, signaling to the stem cells in the bone marrow to come to the site. The scientists were able to pinpoint the signaling molecules - HGF, MMP-9 and SDF-1- and describe the homing process. HGF is involved in liver cell development and, in irregular cases, can play a role in cancer metastasis. MMP-9 assists cell migration from the blood system into various types of tissue, including liver tissue. SDF-1 is a molecule that stem cells are attracted to. The scientists discovered that large amounts of HGF and MMP-9, when overproduced in the damaged liver, enter the blood flow and increase the sensitivity of stem cells in the bone marrow to SDF-1. Suddenly able to sense SDF-1's calling signal from the liver (which itself is amplified due to increased production and distribution of SDF-1), the stem cells migrate from the bone marrow into the blood and navigate their way to the liver. The findings could lead to new insights into organ repair and transplants, especially liver-related ones. They may also uncover a whole new stock of stem cells that can under certain conditions become liver cells. Until a few years ago only embryonic stem cells were thought to possess such capabilities. Understanding how stem cells in the bone marrow turn into liver cells could one day be a great boon to liver repair as well as an alternative to the use of embryonic stem cells.

    Prof. Tsvee Lapidot's research is supported by the Concern Foundation, Beverly Hills, CA; Ms. Rhoda Goldstein, Nanuet, NY; Levine Institute of Applied Science; M.D. Moross Institute for Cancer Research; Ms. Nora Peisner, Hungtington, MI; and Gabrielle Rich Center for Transplantation Biology Research.


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    Stem Cells Can Convert To Liver Tissue, Help Restore Damaged Organ

    Stem Cells Can Convert To Liver Tissue, Help Restore Damaged Organ
    Bone marrow stem cells, when exposed to damaged liver tissue, can quickly convert into healthy liver cells and help repair the damaged organ, according to new research from the Johns Hopkins Kimmel Cancer Center.

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    Related section: Health & Medicine



    In mouse-tissue cultures, scientists found that stem cells, in the presence of cells from damaged liver tissue, developed into liver cells in as little as seven hours. They also observed that stem cells transplanted into mice with liver injuries helped restore liver function within two to seven days. The work was published in the June 1 issue of the journal Nature Cell Biology.

    http://www.sciencedaily.com/releases...0602060318.htm

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