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Thread: Bypassing Stem Cells for Therapeutics

  1. #1

    Bypassing Stem Cells for Therapeutics

    "In 1987, Davis et al2 demonstrated that the ectopic expression of a single gene, myogenic differentiation 1 (MYOD1), could convert fibroblasts into skeletal muscle cells. This sentinel discovery stood alone for years awaiting generalization, but is now recognized as the first of many demonstrations of direct reprogramming: the ability of an adult cell type to become another without passing through a pluripotent state. Since then, direct reprogramming has been documented both between closely related lineages (eg, various hematopoietic fates) as well as between seemingly unrelated cell types (eg, hepatocytes and neurons)."
    In God we trust; all others bring data. - Edwards Deming

  2. #2
    Can someone explain to me why this thread was moved from the Cure Forum?

    Studies using "Direct reprogramming" in SCI have been publisched and posted in the cure forum before.
    This article is not specific for SCI but is very relevant to SCI cure as it shows Direct Reprogramming is already approaching the clinic and it may become a better alternative to stem cells transplantation, therefore this approach might become very important to cure SCI in the near future.

    BTW I got it from Dr. Claude Gerstle who is a doctor with SCI who is well known for the documentary "The Accidental Advocate"

    In God we trust; all others bring data. - Edwards Deming

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