Trends in Neurosciences

Volume 24, Issue 10 SummaryPlus
1 October 2001 Article
Pages 550-552 Journal Format-PDF (263 K)

Research update

Peripheral metabotropic glutamate receptors: fight the pain where it hurts

Volker Neugebauer

Dept of Anatomy and Neurosciences and Marine Biomedical Institute, The University of Texas Medical Branch, Galveston, TX 77555-1069, USA

Available online 21 September 2001.


Recent anatomical and behavioral data show the expression of G-protein coupled metabotropic glutamate receptors in the periphery on nociceptive primary afferent nerve terminals, and provide evidence for a functional role of peripheral metabotropic glutamate receptors in inflammatory pain. These findings have important implications for new therapeutic strategies that target peripheral metabotropic glutamate receptors for pain relief. They also alert us to the necessity of assessing drug effects at different levels of the nervous system: peripheral and central.

Author Keywords: pain; mgluR; inflammation

Subject-index terms: Neuroscience

Article Outline

Anatomical evidence for peripheral mglu receptors
Functional relevance of peripheral mglu receptors in normal nociception
Functional role of peripheral mglu receptors in inflammatory pain
Clinical implications and conclusions