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Thread: Cancer Drug Epothilone Causes Damaged Nerve Cells In Spinal Cord Injuries To Regrow

  1. #11
    Senior Member lunasicc42's Avatar
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    Quote Originally Posted by GRAMMY View Post
    (That would then require the shutdown of the cure forum at the CareCure website). It's the only place on the forum to post the latest research and potential discovery information for the community in spite of most all the threads digressing to unrelated trash.
    I don't mean to sound crass but I think the ultimate goal of the carecure community is to make sure that it sees itself become irrelevant and extinct

    On another note, Apparently the miami project is showing interest in this drug: https://www.themiamiproject.org/sslpage.aspx?pid=1213
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  2. #12
    Quote Originally Posted by wesmaister View Post
    I guess the question is who will try it first...
    I will, right now. Let me try it!

  3. #13
    Quote Originally Posted by lunasicc42 View Post
    I don't mean to sound crass but I think the ultimate goal of the carecure community is to make sure that it sees itself become irrelevant and extinct.
    That's right, but it would be best to have the research completed, clinical trials ran and a treatment taken to bedside before disintegration of the cure threads due to weariness of talking about our options. We don't have a cure yet so we need to allow the meaningful discussions to take place rather than digressing all the threads into a bitch and whine fest which is not helpful.

  4. #14
    Quote Originally Posted by lunasicc42 View Post
    Apparently the miami project is showing interest in this drug: https://www.themiamiproject.org/sslpage.aspx?pid=1213
    I don't mean to sound crass either, but Miami Project is indeed part of the original group mentioned and cited in the Science article posted at the beginning of the thread by Chilacas two weeks ago! Within two hours you posted on the thread that you weren't interested in the same ole talk and yet you're posting even more links on the Epothilone study? ... Isn't this weary stuff you think should be condemned by the community or did you just now notice that the folks at Miami Project were involved in one of their newsletters? Why else would you still be posting more links about this repurposing drug study when you crudely quote that other therapies should be tested first and so on... This is a drug that's already FDA approved and on the market. It doesn't get easier than this my friend so I would keep an open mind and at least be willing to learn about these other options as they present themselves so sci CAN become irrelevant and extinct in the future if that's to be your ultimate goal for the carecure community. We can hopefully look forward to a therapy(s) making it to bedside someday and maybe you'll have learned about the discovery here in the cure threads first if the forum isn't made extinct prematurely by it's members...

    Citation: Jrg Ruschel, Farida Hellal, Kevin C. Flynn, Sebastian Dupraz, David A. Elliott, Andrea Tedeschi, Margaret Bates, Christopher Sliwinski, Gary Brook, Kristina Dobrint, Michael Peitz, Oliver Brstle, Michael D. Norenberg, Armin Blesch, Norbert Weidner, Mary Bartlett Bunge, John L. Bixby and Frank Bradke, "Systemic administration of epothilone B promotes axon regeneration after spinal cord injury", Science doi: 10.1126/science.aaa2958
    Ruschel J1, Hellal F1, Flynn KC1, Dupraz S1, Elliott DA1, Tedeschi A1, Bates M2, Sliwinski C3, Brook G4, Dobrindt K5, Peitz M5, Brstle O5, Norenberg MD6, Blesch A3, Weidner N3, Bunge MB2, Bixby JL2, Bradke F7.

    Author information

    • 1Axonal Growth and Regeneration, German Center for Neurodegenerative Diseases, Ludwig-Erhard-Allee 2, 53175 Bonn, Germany.
    • 2The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, 1095 Northwest 14th Terrace, Miami, FL33136, USA.
    • 3Spinal Cord Injury Center, Heidelberg University Hospital, Schlierbacher Landstr. 200A, 69118 Heidelberg, Germany.
    • 4Institute for Neuropathology, RWTH Aachen University, Steinbergweg 20, 52074, Aachen, Germany. J?lich-Aachen Research Alliance-Translational Brain Medicine.
    • 5Institute of Reconstructive Neurobiology, Life&Brain Center, University of Bonn and Hertie Foundation, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany.
    • 6Departments of Pathology, Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, FL 33101, USA.
    • 7Axonal Growth and Regeneration, German Center for Neurodegenerative Diseases, Ludwig-Erhard-Allee 2, 53175 Bonn, Germany. frank.bradke@dzne.de.

      Abstract

      After central nervous system (CNS) injury, inhibitory factors in the lesion scar and poor axon growth potential prevent axon regeneration. Microtubule stabilization reduces scarring and promotes axon growth. However, the cellular mechanisms of this dual effect remain unclear. Here, delayed systemic administration of a blood-brain barrier permeable microtubule stabilizing drug, epothilone B (epoB), decreased scarring after rodent spinal cord injury (SCI) by abrogating polarization and directed migration of scar-forming fibroblasts. Conversely, epothilone B reactivated neuronal polarization by inducing concerted microtubule polymerization into the axon tip, which propelled axon growth through an inhibitory environment. Together, these drug elicited effects promoted axon regeneration and improved motor function after SCI. With recent clinical approval, epothilones hold promise for clinical use after CNS injury.
    Last edited by GRAMMY; 03-28-2015 at 08:51 AM.

  5. #15
    Senior Member lunasicc42's Avatar
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    yes, I, myself was growing weary of all the new drugs being touted when we should be accelerating the options that we already have. but I posted the article because while "I" might be jaded at certain things, I can still see good reason to share this information with the community
    "That's not smog! It's SMUG!! " - randy marsh, southpark

    "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


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  6. #16
    So iam Little unclear, would this actually help reduce a scar that has already formed in a chronic injury? And Would it cause axons to regenerate and Sproat a new connection?

  7. #17
    Luna there defiantly are a few treatments are being tested right now that could offer some improvement, and actually quite an increase in quality of life. BUT after talking to a researcher, I realize the biggest thing is obviously funding cause neural stemcells and the such are very expensive so we need more facilities to manufacture them to reduce the cost. Only way that with happen is more proven medical applications. Which will take years, so try and get in a trial if you wanna shoot for it. I believe stem cells once fully understood will be a large commodity market, in the future. This drug should be expedited tho, definatly. Hell I'll try it, it safeish dosing will be a shoot in the dark but take a mouse dose that showed improvements and add according to body weight lol I don't know.

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