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Thread: Mesenchymal stem cells

  1. #1

    Mesenchymal stem cells

    Cell Transplant. 2015 Mar 24. [Epub ahead of print]
    Continuous improvement after multiple mesenchymal stem cells transplantations in a patient with complete spinal cord injury.
    Danuta J, Olga M, Anna W, Stanislaw K, Marcin M.


    Interruption of spinal cord (SC) continuity leads to functional loss below the lesion level. The purpose of this study was to evaluate the safety and efficacy of bone marrow nucleated cells (BMNCs) and multiple mesenchymal stem cells (MSCs) transplantations in spinal cord injury (SCI). A patient with total SC interruption at the Th2-3 level underwent experimental therapy with BMNCs and MSCs transplantations followed with intensive neurorehabilitation treatment. At admission, 6 hours after SCI, the patient was scored ASIA A, had a Th1 sensation level, paraplegia with sphincter palsy and was without the ability to control trunk movement. Neurophysiology examination showed bilateral axonal damage to the motor and sensory neural fibers with no motor unit potentials or peripheral motor nerve conduction in the lower extremities. The standard therapy had been applied and had not produce any positive results. The patient was treated with autologous BMNCs injected intravenously (3.2x109) and intrathecally (0.5x109) 10 weeks after the SCI and with five rounds of MSCs every 3-4 months (1.3-3.65x107) administered via lumbar puncture. Total number of transplanted MSC cells during the course of treatment was 1.54x108. There were no complications related to transplantations, and no side effects related to the therapy during 2 years treatment. The ASIA score improved from A to C/D (from 112 to 231 points). The sensation level expanded from Th1 to L3-4, and the patients' ability to control the body trunk was fully restored. Bladder filling sensation, bladder control and anal sensation were also restored. Muscle strength in the left lower extremities improved from plegia to deep paresis (1 on the Lovett scale). The patient's ability to move lower extremities against gravity supported by the movements in quadriceps was restored. The patient gained the ability to stand in a standing frame and was able to walk with the support of hip and knee ortheses. Magnetic resonance imaging (MRI) revealed that at the Th2/Th3 level, where the hemorrhagic necrosis was initially observed, small tissue structures appeared. Our results suggest that repeated intrathecal infusions of mesechymal stem cells might have the potential to produce clinically meaningful improvements for SCI patients.

    PMID: 25807231 [PubMed - as supplied by publisher]
    "I'm manic as hell-
    But I'm goin' strong-
    Left my meds on the sink again-
    My head will be racing by lunchtime"

    <----Scott Weiland---->

  2. #2
    "And these MSCs were sourced from the patent's own bone marrow! Just imagine what eMSCs would do!" saxxie from icell
    Last edited by ineedmyelin; 03-27-2015 at 05:29 PM.
    "I'm manic as hell-
    But I'm goin' strong-
    Left my meds on the sink again-
    My head will be racing by lunchtime"

    <----Scott Weiland---->

  3. #3
    Too bad they didnt try that on a chronic patient. Good for this particular newly injured person but we will never know the real reason for recovery here.

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