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Thread: Miami project opens recruitment for chronic SCI

  1. #1
    Senior Member lunasicc42's Avatar
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    Miami project opens recruitment for chronic SCI

    "That's not smog! It's SMUG!! " - randy marsh, southpark

    "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


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    Senior Member lunasicc42's Avatar
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    to anybody that can help me with a question that I have always had about this ....for this safety phase, they harvest a sural nerve from the leg, isolate the relevant cells (schwann cells ) then inject them into the injury site and couple with rehab. Ok, so what will be different between this safety phase and the efficacy phase? What else to add?
    "That's not smog! It's SMUG!! " - randy marsh, southpark

    "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


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  3. #3
    Quote Originally Posted by lunasicc42 View Post
    to anybody that can help me with a question that I have always had about this ....for this safety phase, they harvest a sural nerve from the leg, isolate the relevant cells (schwann cells ) then inject them into the injury site and couple with rehab. Ok, so what will be different between this safety phase and the efficacy phase? What else to add?
    Could be more cells, could be more rehab, or both. When doing a safety trial, they mainly want to give the smallest dosage they can just to show the surgery and the cells are safe. After that, once it has been shown to be safe, they can get more aggressive and give a higher number of cells and/or more physical training, if thats the direction they decide to go.

    They also say that subjects' SCI must be a minimum of 12 months old, which I think most people would classify as sub-acute, not chronic. This requirement does leave it open for some chronics to be entered though, which is good.

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    Quote Originally Posted by tomsonite View Post
    Could be more cells, could be more rehab, or both. When doing a safety trial, they mainly want to give the smallest dosage they can just to show the surgery and the cells are safe. After that, once it has been shown to be safe, they can get more aggressive and give a higher number of cells and/or more physical training, if thats the direction they decide to go.

    They also say that subjects' SCI must be a minimum of 12 months old, which I think most people would classify as sub-acute, not chronic. This requirement does leave it open for some chronics to be entered though, which is good.
    A minimum of 12 months would be exclusively chronic.

  5. #5
    Senior Member lunasicc42's Avatar
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    Quote Originally Posted by nrf View Post
    A minimum of 12 months would be exclusively chronic.
    Yeah tomsonite, you accidentally had that backwards
    "That's not smog! It's SMUG!! " - randy marsh, southpark

    "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


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  6. #6
    Quote Originally Posted by lunasicc42 View Post
    Yeah tomsonite, you accidentally had that backwards
    Yeah!

    ...wait let me get my pitchfork...

    YEEAHHH!!!!

    lol sorry I got real happy, then sad, and now sort of happy that it could be open to chronics...

    Regards

  7. #7
    What is so special about Schwan cells again? And would the Miami project be the most heavily funded SCI research organization in the US?

  8. #8
    Quote Originally Posted by lunasicc42 View Post
    to anybody that can help me with a question that I have always had about this ....for this safety phase, they harvest a sural nerve from the leg, isolate the relevant cells (schwann cells ) then inject them into the injury site and couple with rehab. Ok, so what will be different between this safety phase and the efficacy phase? What else to add?
    I know you've been waiting for a long time for this trial to happen. I hope it goes well. For humans with chronic SCI, they hypothesize that axons might show improved function if myelin repair is induced with the implantation of ahSC. In addition spinal cord cavitation may be reduced, and neural sprouting and plasticity may be enhanced via neurotrophic effects. It may be that these particular cells would need to be added into certain combo therapies in the future depending on the particular type of SCI injury.
    Let's hope they perform well in people!
    Last edited by GRAMMY; 02-13-2015 at 01:47 AM. Reason: spelling

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    Senior Member lynnifer's Avatar
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    Quote Originally Posted by JamesMcM View Post
    What is so special about Schwan cells again? And would the Miami project be the most heavily funded SCI research organization in the US?
    Read: http://www.themiamiproject.org/page.aspx?pid=861
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    Senior Member tarheelandy's Avatar
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    I wonder why they are only using 2 people for the trial?

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