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Thread: Doctors in China carry out world first spine surgery

  1. #241
    alan gong and jyi, our website requires that you post in English. In the future, please add a translation. Thank you.

  2. #242
    Junior Member
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    Sorry, my English is very poor. I will try my best. btw, I think alan gong's "微信" means WeChat , an online instant messaging app.

    Quote Originally Posted by Jim View Post
    alan gong and jyi, our website requires that you post in English. In the future, please add a translation. Thank you.

  3. #243
    OK are they actually fully removing the scar tissue from the spinal cord before enplaning the collagen scaffold? I'm pretty sure that I read in the official statements that is what they're doing.

  4. #244
    Scar tissue does not prevent regeneration.

  5. #245
    Well I've heard from many that it does. The glial do they not remove that and then plant the collagen scaffolding in the lesion left behind

  6. #246
    Quote Originally Posted by Jim View Post
    Scar tissue does not prevent regeneration.
    Not everybody agree with you:

    "Following injury, specialised glial cells that normally support neurons accumulate at the injury site and deposit scar tissue.
    Scar tissue is a major obstacle to spinal cord repair because it creates a physical and biochemical blockage that neurons must grow through. Perhaps more importantly, molecules that inhibit neuronal growth are especially concentrated in the scar."

    http://www.spinal-research.org/resea...y-scar-tissue/

    Perhaps you just meant to say that some researchers believe "scar tissue does not prevent regeneration" and some do.
    In God we trust; all others bring data. - Edwards Deming

  7. #247
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    "We show that glial scar, which is common in neurodegenerative conditions, inhibits the survival of intraneurally transplanted cells in our rat glial scar model in the auditory system. However, cells placed on the surface of scar tissue autonomously enter the nerve and become functionally integrated into the host. The glial scar, normally considered to be a barrier to cell transplantation, includes important structural and chemical cues that are disrupted by intraneural delivery but preserved by surface transplantation."

    "Our results show that intraneural transplantation to the auditory nerve, preceded by chondroitinase ABC (ChABC)-treatment, is ineffective. There is no functional recovery, and almost all transplanted cells die within a few weeks. However, when donor cells are placed on the surface of a ChABC-treated gliotic auditory nerve, they autonomously migrate into it and recapitulate glia- and neuron-guided cell migration modes to repair the auditory pathway and recover auditory function."

    http://www.pnas.org/content/112/26/E3431
    Last edited by Jyi; 08-24-2015 at 08:29 PM.

  8. #248
    Unfortunately, Chondroitinase isn't available yet for humans. Stay tuned to the translative work of Spinal Research in the U.K.

  9. #249
    Quote Originally Posted by Jim View Post
    Scar tissue does not prevent regeneration.
    Jim, while I personally believe this is open for debate, those from your/Wise's camp often make this point on here, yet no alternative theory is provided.

    Could you elaborate on what DOES prevent regeneration, in your/Wise's opinion? Even if it is not gliosis at the site of the injury, obviously something is preventing functional regeneration - otherwise everyone would be ASIA E after their injury.

  10. #250
    Quote Originally Posted by tomsonite View Post
    Jim, while I personally believe this is open for debate, those from your/Wise's camp often make this point on here, yet no alternative theory is provided.

    Could you elaborate on what DOES prevent regeneration, in your/Wise's opinion? Even if it is not gliosis at the site of the injury, obviously something is preventing functional regeneration - otherwise everyone would be ASIA E after their injury.
    There is a lack of a cellular bridge for axons to travel.

    Most importantly, is that adult neurons don't regenerate their axons. It is genetic. You can get rid of any scar obstruction, provide a beautiful bridge to cross, but the axons would still not move. You may find proof of .0001% that may move a few mm's but the overwhelming majority intrinsically do not move. This is why genetic therapy is really the only way to get host axons to regenerate, imo.

    Even if you could get them to miraculously regenerate, they wouldn't know where to go. SCI is like a brain injury, only with the cord (same tissue as brain).

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