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Thread: Doctors in China carry out world first spine surgery

  1. #271
    Quote Originally Posted by paolocipolla View Post
    One aspect that could be very important is what signals from the injured axon (injury site) get to the cell body. It seems that in the PNS you have different signals than in the CNS traveling to the cell body that cause a cascade of events that result in regneration of the axon. It is probably more complex than this, but that seems a possible part of the problem..
    Quote Originally Posted by Nowhere Man View Post
    I agree. I also think those signals would be vital to guiding a regenerated axon, because they have no idea where to go. It just goes to show how highly complex a problem like SCI truly is, and how far away an effective treatment really is. People need to stop looking at the finish line and start looking at the starting gate.
    You bring up a good point Paolo. Even that I would consider an environmental factor...if a signal can travel down an un-interrupted CNS axon to a lower motor neuron, then that neuron is told to fire over and over and over again - if the injury to the peripheral nerve isn't too severe, then astrocytes keep detecting an electrical charge sent out from the neuron, myelin is produced, the axon regenerates, and function is restored.
    If, however, there is a disruption to the CNS (lack of myelin secondary to an SCI, for instance), then a signal might never travel far enough to get astrocytes that survived the injury to signal for more myelin production, therefore not creating a path for axons that are capable of regenerating.

    Nowhere Man, while we haven't been presented with a scenario yet where we can test if the correct signals can guide regenerating axons, we do know that incomplete some incomplete SCIs can vastly improve their gross motor abilities (walking speed and skill) without any change in ASIA scores. The CNS is capable of robust re-organization after an injury - hopefully the same principles that have been documented so far will still apply to successful regenerative techniques once they are discovered.

  2. #272
    Senior Member Imight's Avatar
    Join Date
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    [QUOTE = alan gong; 1776543] their official micro-channel platform Translation- Their official Micro-Channel Platform [/ QUOTE]

    what is their wechat?

  3. #273
    Quote Originally Posted by y8225009 View Post
    All the patients are chronic complete injury.
    Quote Originally Posted by east dragon View Post
    all are chronic

    Quote Originally Posted by Silvio GS View Post
    Institute of Genetics and Developmental Biology Dai Jianwu regenerative medicine research team by more than ten years of efforts, the successful development of collagen scaffolds can be used for nerve regeneration in spinal cord injury repair. Chinese Academy of Sciences Stem cell research and regenerative medicine. Support strategic pilot science and technology projects, the completion of the repair of spinal cord injury multiple batches of animal experiments, the development of product standards and type testing completed. In January 2015 and April 2015 - May were completed two stages totaling enrolled 26 subjects with spinal cord injury, including 25 cases of chronic spinal cord injury in a subject, and one case of acute spinal cord injury in a subject. So far, the subject was not found with the scaffold transplant or surgery-related serious adverse reactions, surgical safety is good. One example of acute complete spinal cord injury in April 2015 enrolled subject show significant improvement in sensory function and motor function, the preliminary results are encouraging.

    To speed up the acute complete spinal cord injury clinical study subjects into groups based on acute spinal cord injury patients fragmented and needed to carry out the nearest require early surgery, it is proposed to increase the number of hospital clinical experience with certain spinal cord injury and rehabilitation conditions to participate in clinical research team Please interested in participating in clinical research in spinal cord injury neurosurgery or spinal surgery contact us. Also, for some reason temporarily unable to participate in clinical research team received hospital patients with acute injury (within one week), please first time to contact us, we will consider equal treatment in accordance with the co-operation.

    Contact: Xiao teacher
    Tel: 010-82614420
    So they are leaning future trial phases toward acute injury?

    Did anyone get to read a published stem cell paper on the 170 dogs experimented on and mentioned earlier?
    Last edited by GRAMMY; 09-15-2015 at 02:25 PM.

  4. #274
    That's got me confused. Is it working in complete injuries and if so why does it seem that they are leaning towards acute injuries?

  5. #275
    Bad news from the trial hospital. They are going to give up the trail about chronic injuries. I feel sick. It sounds like a hoax.

  6. #276
    Senior Member Imight's Avatar
    Join Date
    Nov 2007
    Quote Originally Posted by alan gong View Post
    Bad news from the trial hospital. They are going to give up the trail about chronic injuries. I feel sick. It sounds like a hoax.
    January 16, 2015, the world's first case of nerve regeneration between collagen scaffold combined with mesenchymal stem cells to treat spinal cord injury surgery done in Chinese People's Armed Police Hospital brain nerve Spine Section. The first batch of 12 patients have completed surgery, the results of these surgical patients showed no problem with security of the operation, some patients showed improved sensory and autonomic function, especially in patients with acute case of injury, improved after the more obvious. So the follow-up clinical studies are more inclined to acute injury, and patient recruitment briefing released again.

    Through bio-synthesis technology we have been able to create some allow nerve healing scaffolds, and in animal experiments to allow paralyzed dog standing and walking. But the findings show that the transformation of spinal cord injury can occur within one year to six months after injury, spinal cord injury atrophy, defect increased difficulty scaffold for the increase, but in patients with new onset of paralysis was able to play a very significant role, promising to cure paralysis.

  7. #277
    Make sense, there's just nothing to work with in regards to implanting a large scaffold

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