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Thread: New "cure" from uk and Poland. Been posted yet

  1. #11
    Moderator kate's Avatar
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    Quote Originally Posted by GRAMMY View Post
    It appears they have reason to look forward at Ph 2 & 3 clinical trials.
    Agree. It's going to take for effing ever to see how this plays out, eh? 6 months post intervention before the first sensation returns. Wow.

    For grins, here's what Sam Maddox wrote about the OEG approach just a few months ago. It's a good cautionary tale, IMO, about why as much as we all hate the snail's pace of science, there's a downside to rushing in.

    The gist of his article is that getting ahead of a promising therapy before its time is not always going to turn out well.

  2. #12
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    Something we probably know already, but it's interesting to hear this in the news:

    The lack of financial incentive for the pharmaceutical industry could help explain why it has taken so long for the research to get this far. Using a patient's own cells to heal them means there is no profit for the pharmaceutical industry.

    Prof Raisman said: "It would be my proudest boast if I could say that no patient had had to pay one penny for any of the information we have found." [MORE]

  3. #13
    The Independent isn't just good news. Look at this tragedy!
    http://www.independent.co.uk/news/uk...s-9806972.html

  4. #14
    Quote Originally Posted by Nowhere Man View Post
    No way was regeneration of the cord the mechanism of recovery. Had to be remyelination/sprouting of existing nerve fibers. Great news nonetheless if it is real.
    The technique the article describes is somewhat similar to what Dr. Yu Shang Lee and Dr. Jerry Silver are doing. Here they describe peripheral nerve bridges taken from the sural nerve in the ankle + ensheathing glia cultured from the patients olfactory bulb injected into the cord stumps on either side of the bridge. (Ensheathing glia modulate CSPGs and help to create a nice aligned interface between the Schwann cells in the graft and astrocytes in the cord). Lots of physical therapy was given to this stab victim as well. If you remember correctly, Dr. Silver used FGF and Condroitinase to accomplish basically the same thing. Among possible mechanisms for the functional improvement both the MEPs and DTI studies suggest that transplantation of OECs may mediate some restitution of efferent and afferent long white matter tracts in these patients. I'm guessing the scientific paper tomorrow will be a follow up report on the stabbing victim firefighter that was mentioned in the 2013 paper. The London team and their collaborators at Wroclaw Medical University now need to raise about 10m to fund surgery in Poland for a further group of around ten patients to test and refine the implant technique over the next five years. Researchers are also exploring the possibility of bringing the technique to a British specialist unit.

    Last edited by GRAMMY; 10-21-2014 at 12:00 AM.

  5. #15
    Very excited to see how the technique develops while comparing the results from multiple teams and neurosurgery centers. First surgery performed on a "severed" cord resulting from a knife injury? ASIA A to C is a pretty amazing jump. Can't wait to see the functional return achieved from a few more test cases. Will be reading the published paper tomorrow.

  6. #16
    Quote Originally Posted by kate View Post
    Agree. It's going to take for effing ever to see how this plays out, eh? 6 months post intervention before the first sensation returns. Wow.

    For grins, here's what Sam Maddox wrote about the OEG approach just a few months ago. It's a good cautionary tale, IMO, about why as much as we all hate the snail's pace of science, there's a downside to rushing in.

    The gist of his article is that getting ahead of a promising therapy before its time is not always going to turn out well.
    Agreed. I'd be concerned about using the ‘raw’ nasal mucosa OEG as used by Lima... Agreed. I'd be concerned about using the ‘raw’ nasal mucosa OEG as used by Lima... According to this article however, working alongside the British researchers, Dr Tabakow developed the technique to implant cultured OECs harvested from a patient’s own olfactory bulb - and another type of nasal cell known as a fibroblast - on the stumps of a severed spinal cord. A scaffolding of nerve tissue was taken from the ankle to join the two ends of the cord to encourage bridging by the cells.
    Last edited by GRAMMY; 10-21-2014 at 05:25 AM.

  7. #17
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    would this be technically still feasible with a burst cord as apposed to severed ?

  8. #18
    Quote Originally Posted by scurl View Post
    would this be technically still feasible with a burst cord as apposed to severed ?
    Do you mean "contusion" like a bruised cord?

  9. #19
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    Quote Originally Posted by GRAMMY View Post
    Do you mean "contusion" like a bruised cord?
    hmm no my injury is c6/c7 burst the cord. I guess due to compression.

  10. #20
    Quote Originally Posted by scurl View Post
    would this be technically still feasible with a burst cord as apposed to severed ?
    This nerve graft study was done in particular on a severed injury (stab wound) resulting in an 8mm gap. I think they'll need to do additional studies to know for sure which injuries may benefit from the procedure and how feasible recovery would be for other types of injury.

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