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Thread: Glial scars

  1. #41
    Senior Member alan's Avatar
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    I don't know what it is still growing between my two little cervical syrinxes (it isn't another syrinx - the doctors who looked at my MRIs called it scar tissue), but my remaining cord which somehow have to grow through the little C-4 syrinx, then that mystery tissue, then the little C-6 syrinx. That would be something.
    Alan

    Proofread carefully to see if you any words out.

  2. #42

  3. #43
    On the contrary, there is, it just has a different name Condoliase they ar doing a CT for lumbar disc herniation http://www.clinicaltrialssearch.org/...al-trials.html what a shame! Wise mentioned it in one of his posts that they can't do two CT at the same time for the same drug which makes sense, anyway there are better alternatives like sialidase http://www.science.gov/topicpages/c/...abc+chabc.html

  4. #44
    Quote Originally Posted by mrwilsonsfc View Post
    On the contrary, there is, it just has a different name Condoliase they ar doing a CT for lumbar disc herniation http://www.clinicaltrialssearch.org/...al-trials.html what a shame! Wise mentioned it in one of his posts that they can't do two CT at the same time for the same drug which makes sense, anyway there are better alternatives like sialidase http://www.science.gov/topicpages/c/...abc+chabc.html
    http://sci.rutgers.edu/forum/showthr...=1#post1520187

    http://sci.rutgers.edu/forum/showthr...=1#post1524299

    http://sci.rutgers.edu/forum/showthr...=1#post1543931
    It wasn't Wise that posted the dual CT possibility, it was me. I contacted the Seikagaku Corporation about doing a future SCI trial with Condoliase (generic chABC) along with disc hernia and posted it here.

    Sialidase alone won't provide near the robust results as Ch'ase. Combined with Ch'ase it failed to improve outcomes.
    Last edited by GRAMMY; 12-23-2014 at 10:17 PM.

  5. #45
    Not according to the study referenced in my previous post

  6. #46
    Quote Originally Posted by mrwilsonsfc View Post
    Not according to the study referenced in my previous post
    (1) Administration of sialidase to chronic spinal animals would be key to validation of sialidase as a therapy. (Not done yet to the best of my knowledge). The study was done on a moderate contusion T9 (200 kdyne) infusion at the time of impact on the animal (extreme acute).
    (2) They haven't tested encapsulation for delivery so it's unknown if it would perform as well as the results from the Bellamkonda lab in Georgia with trehalose or if they can maintain the same delivery dosage that gave them results by other means.
    (3) It could be that higher dose of chABC may also produce similar results too. (The paper does however find the appropriate dosage of sialidase to improve rat hindlimb function).
    (4) The functional data in this paper are striking, it would be interesting to see if these can be reproduced by other labs, (very necessary)
    (5) Continued sialidase funding from the NIH was denied. (Due in part to the poor federal biomedical funding environment in 2013-14).
    (6) I don't know of any company interested in pursuing sialidase as a therapeutic.

    Who knows, maybe eventually in future decades someone with a billion dollars will turn it into the next miracle drug for chronic sci, but for now I personally don't think this is a viable nor better alternative to get excited about anytime soon.
    Last edited by GRAMMY; 12-23-2014 at 10:18 PM.

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