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Thread: neuralstems

  1. #1
    Senior Member PC720's Avatar
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    neuralstems

    http://money.cnn.com/news/newsfeeds/...re/PH33434.htm.

    Neuralstem, Inc. (NYSE MKT: CUR) announced that the first patient was treated last week in the Phase I trial testing NSI-566 human neural stem cells in the treatment of chronic spinal cord injury (cSCI) at the UC San Diego School of Medicine. The patient has been discharged from the hospital. The NSI-566/cSCI Phase I trial will treat four patients who have thoracic spinal cord injuries (T2-T12) with stem cell transplants directly into the region of the injury, between one and two years post-injury. All of the patients have an American Spinal Injury Association (AIS) grade A level of impairment, which is complete paralysis with no motor or sensory function in the relevant segments at and below the injury. The trial is under the direction of principal investigator (PI) Joseph Ciacci, MD, UC San Diego School of Medicine and neurosurgeon at UC San Diego Health System. Much of the pre-clinical work with the NSI-566 cells in spinal cord injury was conducted at UC San Diego School of Medicine by Martin Marsala, MD, professor in the Department of Anesthesiology, who will be another study investigator.
    Karl Johe, PhD, Neuralstem's Chairman and Chief Scientific Officer, explained the scientific rationale behind the Neuralstem therapy. "The therapeutic mechanism of action for the neural stem cell transplantation in chronic spinal cord injury is for the transplant to 'bridge the circuitry gap' in the cord which resulted from the injury. To return meaningful function to the patients, existing nerves from above the injury will need to traverse and connect to the intact area below the injury, which we believe can happen via our transplant. The new nerves generated from the transplant itself can connect to the host cord above and below the injury and contribute to the rebuilding of the damaged circuitry, as demonstrated in animal studies (Lu, Gorp). This structural repair by NSI-566 in chronic SCI patients will be in addition to the neuroprotective factor expression demonstrated in ALS patients who have undergone transplantation with the same cells."
    This clinical trial at UC San Diego Health System is funded by Neuralstem, Inc. and was launched and supported by the UC San Diego Sanford Stem Cell Clinical Center. The Center was recently created to advance leading-edge stem cell medicine and science, protect and counsel patients, and accelerate innovative stem cell research into patient diagnostics and therapy.

  2. #2
    Senior Member PC720's Avatar
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    sorry that title should have read neural stem has treated their first sci patient. my shaky fingers accidentally hit the button to post

  3. #3
    Senior Member Leo's Avatar
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    really great news imo
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  4. #4
    I always thought from reading Wise's posts that the neurons below the injury died off and that long tracts would have to be regenerated to the target muscles. As it reads above, it says that they hope that the injections will reconnect above and below the injury, contrary to what I understand.

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    Senior Member PC720's Avatar
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    Quote Originally Posted by Sebastiang View Post
    I always thought from reading Wise's posts that the neurons below the injury died off and that long tracts would have to be regenerated to the target muscles. As it reads above, it says that they hope that the injections will reconnect above and below the injury, contrary to what I understand.
    I'm not so sure about this. He has said in his YouTube videos that it was once believed neurons below the site of injury died off, and it does in fact atrophy: however,research has shown quite the opposite. there is quite a bit of life flourishing below the site of injury
    Last edited by PC720; 10-12-2014 at 11:44 AM.

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