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Thread: PTEN Deletion Plus Fish Fibrin Promotes Recovery

  1. #1
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    PTEN Deletion Plus Fish Fibrin Promotes Recovery


  2. #2
    Thanks for posting this Bob.
    I think is an interesting progress, but PTEN deletion was done BEFORE animal injury, so it is not yet clinically rilevant.

    Also "There were no significant differences in lesion size between the groups"
    http://www.jneurosci.org/content/34/...6-8e263fce1e30

    I expected to see a smaller lesion size when animals recover since PTEN deletion it is suppose to bust regeneration.

    A part from the study I have a 2 questions:

    Do you know what is the annual budget of the Reeve Irvine Research center?
    What % of it is spent on research to find a cure for SCI?

    Paolo
    In God we trust; all others bring data. - Edwards Deming

  3. #3
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    The most important part of the recently published article are these two sentences from Sam Maddox's blog post:

    "Indeed what the new paper adds to the story is quite remarkable: a specific forepaw function (reaching for food pellets) on the staircase was restored nearly completely ? 95 percent -- for some tasks in treated rats compared to function measured pre-injury. It is quite possible there has never been a claim for recovery this close to normal in all of spinal cord research."

    Clinically relevant experiments are underway. Neural stem cells are being combined with PTEN inhibition with the hope that the lesion site will be filled and that axons will extend out of the lesion as in Paul Lu and Mark Tuszynski's 2012 paper.

    My knowledge of the Reeve Irvine Research Center is incomplete. There were five labs at RIRC, now there are four as Hans Keirstead left academia to run his company, California Stem Cell. To run a big time 20 person research lab costs a1bout $1 million per year. Each of the four research labs is responsible for raising money for their own labs. RIRC does not have money to give to the labs. Prior to the recession RIRC had an annual budget of $130,000. The money was for the annual Meet the Scientists Meeting, printing and mailing the quarterly Spinal Connections newsletter, the annual Reeve Irvine Metal award ceremony and meeting plus small amount of staff salaries for tours of the RIRC. To answer your question - $130,000 divided by $4 million = 97% spent on cure research before the recession. This year the RIRC budget is almost zero. The newsletter is no longer printed and is now sent digitally. The amount of money currently spent on cure research is close to 100%.

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