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Thread: Sudden drops in blood pressure

  1. #1
    More evidence.


    1. J Neuroimmune Pharmacol. 2013 Mar;8(1):202-11. doi: 10.1007/s11481-012-9428-2. Epub 2012 Dec 16. Cytokine modulation is necessary for efficacious treatment of experimental neuropathic pain. Sacerdote P, Franchi S, Moretti S, Castelli M, Procacci P, Magnaghi V, Panerai AE. Dipartimento di Scienze Farmacologiche e Biomolecolari, UniversitÃ* degli studi di Milano, Via Vanvitelli 32, 20129 Milan, Italy. paola.sacerdote@unimi.it Neuropathic pain originates from a damage or disease affecting the somatosensory system. Its treatment is unsatisfactory as it appears refractory to most analgesics. Animal models of neuropathic pain are now available that help to clarify the underlying mechanisms. Recently it has been recognized that inflammatory and immune mechanisms in the peripheral and in the central nervous system play a role in the onset and the maintenance of pain. In response to nervous tissue damage, activation of resident or recruited immune cells leads to the production of inflammatory mediators, as cytokines. In models of neuropathic pain, such as nerve injury and diabetes induced neuropathy, the time course of the expression of the proinflammatory cytokines TNF-α,IL-1β and IL-6 and of the antiinflammatory cytokine IL-10 has been well characterized both in the peripheral (sciatic nerve, dorsal root ganglia) and the central (spinal cord) nervous system. These cytokines appear activated/modulated in the nervous tissue in parallel with the occurrence of painful behaviour, i.e. allodynia and hyperalgesia. Novel therapeutic approaches efficacious to reduce painful symptoms, for example treatments with the non specific purinergic antagonist PPADS, the phytoestrogen genistein and a cell stem therapy with murine adult neural stem cells also re-established a balance between pro and antinflammatory mediators in the peripheral and central nervous system. These data suggest a pivotal role of immune system and inflammation in neuropathic pain. The modulation of inflammatory molecules appears to be a common trait accomplished throughout different mechanisms by different drugs that might converge in neuropathic pain modulation.

  2. #2

    Sudden drops in blood pressure

    My mother is a 66 yr old C5 quad who has been having problems with sudden drops in blood pressure. She has been having them for a couple of years now, but they seem to be getting more frequent and lasting longer. When she has an episode she takes a salt pill and lays down with her feet elevated, which usually helps. Ever since her accident she has needed to lay down a couple of times a day to rest in addition to taking pressure off of her back and gets tired in the evening, but lately she has seemed listless and somewhat out of it on a regular basis. The episodes usually occur mid-morning around 10:30 and mid-afternoon around 2 pm.

    She has seen a cardiologist who ran a variety of tests and ruled out heart problems but didn't have any ideas on what was causing the problem. The episodes are more frequent when she has or is recovering from a UTI or other illness, is under stress or is worn out from travelling or other activities, but occur even when none of those conditions are present. Her previous primary care doctor was also at a loss about the cause. She is seeing her new primary care doctor this week, but doesn't hold out much hope that he'll have any better idea about what is causing the episodes or what to do. This has become a major issue for her quality of life and is making me increasingly concerned about her physical and mental health. She has remained very active since her injury, but is increasingly limited in what she can do and doesn't bounce back like she used to.

    I was hoping folks here might have some ideas about possible causes that her doctor should investigate and advice on what she can do. I'd also be interested in any suggestions of specialists she should see, both type of specialist as well as any specific doctors people would recommend. She lives in Northeastern Pennsylvania and would be willing to travel to Philadelphia or New York for the right doctor. I live in Washington, DC so she could visit me and see a doctor here as well. I would be incredibly grateful for any advice and suggestions.

    Ed

    PS I used to be an active member here under the user name Cubsfandc but haven't been here in a while and forgot my password so I had to set up a new account

  3. #3
    It would make more sense to me that the episodes are more frequent when her body is stressed. You react to stress with physical symptoms, often, whether it is fatigue or insomnia, etc. Has she changed her diet or fluid intake at all? Any changes in medications? Any other major life stressers?
    CKF

  4. #4
    She has been under more stress recently between my sister being diagnosed with bipolar disorder and struggling to adjust along with drama with her aides. I sort of suspected that the stress is a contributing factor, but was still wondering if there is an underlying factor we should be looking for. But maybe it is just something she has to deal with.

  5. #5
    Super Moderator Sue Pendleton's Avatar
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    She might benefit from being tested for chronic fatigue syndrome. This should be easily done locally and if positive she might want to be managed by a physiatrist or other specialist her regular doctor suggests.
    Courage doesn't always roar. Sometimes courage is the quiet voice at the end of the day saying, "I will try again tomorrow."

    Disclaimer: Answers, suggestions, and/or comments do not constitute medical advice expressed or implied and are based solely on my experiences as a SCI patient. Please consult your attending physician for medical advise and treatment. In the event of a medical emergency please call 911.

  6. #6
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    Proamatine or Midronine is what I use and it helps keep my blood pressure up.

  7. #7
    My blood pressure is very low, too. A few years ago I discovered that pressing my fist into my lower belly pushes up my shoulders, and I sit much more comfortable. Since then I buy a motorcycle kidney belt, the softest I can find, every year or so, untill they are worn out. My marker is my belly button as the highest point; any higher it's not working. A great side effect is that it keeps the blood from rushing into the legs and thereby rises the blood pressure a little bit. It's interesting when the belt slides up unnoticed, I get dizzy right away, and know the belt got loose, without even looking. The one I'm using now was only 9,99 Euros; I know they make them as medicinal binders for hundreds of Euros, but those actually caused pressure sores for me. The simplest ones from motorbike shops do stretch and are elastic. Maybe that could help your mom.

  8. #8
    Thanks Chris. Based on a quick interenet search for Proamatine or Midronine it looks like this is only for extreme cases, which may apply to my mother's situation, but could cause problems when lying down, which my mother does a few times a day. Curious if anyone else has experience with it or thoughts about it.

  9. #9
    Her primary doctor suggested her drops in BP might be related to thoracic something and ordered a sonogram, but she couldn't remember exactly what he said. Any idea what that might be and whether that makes sense as a possible cause?

    Quote Originally Posted by Lorenzen View Post
    My mother is a 66 yr old C5 quad who has been having problems with sudden drops in blood pressure. She has been having them for a couple of years now, but they seem to be getting more frequent and lasting longer. When she has an episode she takes a salt pill and lays down with her feet elevated, which usually helps. Ever since her accident she has needed to lay down a couple of times a day to rest in addition to taking pressure off of her back and gets tired in the evening, but lately she has seemed listless and somewhat out of it on a regular basis. The episodes usually occur mid-morning around 10:30 and mid-afternoon around 2 pm.

    She has seen a cardiologist who ran a variety of tests and ruled out heart problems but didn't have any ideas on what was causing the problem. The episodes are more frequent when she has or is recovering from a UTI or other illness, is under stress or is worn out from travelling or other activities, but occur even when none of those conditions are present. Her previous primary care doctor was also at a loss about the cause. She is seeing her new primary care doctor this week, but doesn't hold out much hope that he'll have any better idea about what is causing the episodes or what to do. This has become a major issue for her quality of life and is making me increasingly concerned about her physical and mental health. She has remained very active since her injury, but is increasingly limited in what she can do and doesn't bounce back like she used to.

    I was hoping folks here might have some ideas about possible causes that her doctor should investigate and advice on what she can do. I'd also be interested in any suggestions of specialists she should see, both type of specialist as well as any specific doctors people would recommend. She lives in Northeastern Pennsylvania and would be willing to travel to Philadelphia or New York for the right doctor. I live in Washington, DC so she could visit me and see a doctor here as well. I would be incredibly grateful for any advice and suggestions.

    Ed

    PS I used to be an active member here under the user name Cubsfandc but haven't been here in a while and forgot my password so I had to set up a new account

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