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Thread: Neuralstem announces results from Phase I trial using NSI-566 spinal cord stem cells

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    Senior Member Leo's Avatar
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    Neuralstem announces results from Phase I trial using NSI-566 spinal cord stem cells

    Neuralstem, Inc. (NYSE MKT: CUR) announced that the final results from the Phase I safety trial using NSI-566 spinal cord stem cells in the treatment of amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease) were published in the peer-reviewed journal, "Annals of Neurology". In "Intraspinal Neural Stem Cell Transplantation in Amyotrophic Lateral Sclerosis: Phase I Trial Outcomes," results were updated from Phase I interim data, reported earlier, to include data from the last six patients in the trial. These six patients were the first to receive cervical stem cell transplants. Three of them were also the first to be transplanted along the length of their spines, in both the lumbar and the cervical regions. The results showed that NSI-566 human spinal cord stem cells can be safely transplanted in both the lumbar and cervical spinal cord segments, did not accelerate disease progression, and warrant further study on dosing and therapeutic efficacy. Furthermore, the researchers were able to identify potential therapeutic windows, suggesting that more injections, as well as multiple injections, are better and may increase both the length and the magnitude of the potential benefits. This is consistent with the hypothesized neuroprotective mechanism-of-action for this cell therapy.

    http://www.news-medical.net/news/201...nt-of-ALS.aspx
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    "You kids and your cures, why back when I was injured they gave us a wheelchair and that's the way it was and we liked it!" Grumpy Old Man

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    Senior Member Leo's Avatar
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    i don't know why but i have always figured als is a harder tackle than sci

    am i pretty far off
    http://justadollarplease.org/

    2010 SCINet Clinical Trial Support Squad Member

    "You kids and your cures, why back when I was injured they gave us a wheelchair and that's the way it was and we liked it!" Grumpy Old Man

    .."i used to be able to goof around so much because i knew Superman had my back. now all i've got is his example -- and that's gonna have to be enough."

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    Super Moderator Sue Pendleton's Avatar
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    Quote Originally Posted by Leo View Post
    i don't know why but i have always figured als is a harder tackle than sci

    am i pretty far off
    I would agree with you, Leo. ALS progresses quickly and current treatment is aimed at correcting or maintaining the body neurologically but not as much that is promising in actually curing the underlying disease. The same goes with MS. Companies look at trials on ALS because it is most often lethal within 5 years of diagnosis where SCI is a more static condition. The same goes with infants with SMA1. The FDA is more likely to approve human trials in conditions that are decidedly deadly within a short time.
    Courage doesn't always roar. Sometimes courage is the quiet voice at the end of the day saying, "I will try again tomorrow."

    Disclaimer: Answers, suggestions, and/or comments do not constitute medical advice expressed or implied and are based solely on my experiences as a SCI patient. Please consult your attending physician for medical advise and treatment. In the event of a medical emergency please call 911.

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