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Thread: Epidural Stimulation Future Trials and Commercial Planning

  1. #1

  2. #2
    Promising. At least it's something moving forward.

  3. #3
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    GRAMMY, What about quads? Does this device have any promise for hand and arm function?

  4. #4
    Quote Originally Posted by #LHB# View Post
    GRAMMY, What about quads? Does this device have any promise for hand and arm function?
    So far, epidural stimulators have only been implanted into the lumbar spinal cord, and thus have only been shown to allow more movement/function in leg and hip muscles, with some possible return of trunk muscles as well. Reggie Edgerton's team at UCLA are now looking into ways of converting this technology into something useful for hand function.

  5. #5
    Quote Originally Posted by #LHB# View Post
    GRAMMY, What about quads? Does this device have any promise for hand and arm function?
    It appears they're going to find out about that in future studies. Let's hope it helps! I'll try to keep an eye on the progress as it unfolds.

    http://newsroom.ucla.edu/portal/ucla...on-249702.aspx

    There will be a couple video's online shortly (if it's not already there)...presentations about Armeo from the Working 2 Walk 2013 video library and other devices.

    Upper Extremity Rehabilitation with the ArmeoSpring - Stefan Bircher
    Stefan Bircher, PhD, Executive Vice President of Hocoma, Inc., illustrates several of the products offered by his company. Hocoma specializes in providing assistive technology devices to help restore function after spinal cord injury and other neurological impairments.

    The Role of Technology in Rehabilitation Medicine
    Dr. Bonato directs the Motion Analysis Lab at Spaulding Rehabilitation Hospital. He discusses the use of wearable systems and robotics in today's rehabilitation setting.

    The video library can be accessed here: http://u2fp.org/video-library/

  6. #6
    ..my prediction..
    it's going to be a big waste of time, money and hopes.. it's just going to take 10 years for all people to realize that... starting from May the 20th, 2011
    http://blogs.scientificamerican.com/...ralysis-again/

    I understand for many people this "hope" will make a difference between living and dying, so it may worth the money for them, but at the same time it wiil take monay away from regenerative research which one day will bring us a real cure hopefully.

    Just my opinion here.. so I hope Grammy and others will agree I have the right to express my opinion even when it is different from what they think

    Paolo
    Last edited by paolocipolla; 03-04-2014 at 06:40 PM.
    In God we trust; all others bring data. - Edwards Deming

  7. #7
    You indeed have the right to express your opinions Paolo. My opinion is that your opinion is way off base.

    It is not a theory that epidural stimulation can return standing, voluntary movement, bowel, bladder, and sexual control, as well as temperature regulation for people with spinal cord injuries. It is a FACT. It has been demonstrated and been reproduced in more than one person. How is that a waste of time? It has gotten results!

    You yourself often say we need research that will "get people out of wheelchairs." People having the ability to stand under their own volition, even if they have to hold on to something to balance, is, quite literally, getting people out of their wheelchairs.

    Just because epidural stimulation doesn't involve regenerating the spinal cord does not mean it isn't cure research. It has gotten significantly more return of function in humans with chronic and complete SCI than any other therapy in history. How you call this a waste of time and money is beyond me.

    My prediction is that this could be a very significant part of what will be a cure. No one therapy or method will be a cure all to SCI.

  8. #8
    I completely agree with tomsonite. The return of bowel, bladder, sexual function and the ability to maintain or regain some muscle mass in the legs would be worth so much to so many that Paolos comments are, like you said, WAY off base.

  9. #9
    Science sees future beyond ParalympicsPublish Date: Mar 05, 2014
    Science sees future beyond Paralympics

    http://www.newvision.co.ug/news/6531...ralympics.html

    PARIS - Imagine a future with no sporting events for paralysed people. A future in which there is no need, as all the would-be competitors will have been cured.

    This scenario, laughable just a few decades ago, is no longer far-fetched, experts say.

    Bit by bit, important progress is being made in understanding and tackling aspects of paralysis.

    Some believe the time is fast approaching when the major secondary problems from paralysis -- bowel, bladder and sexual dysfunction, breathing complications, declining muscle tone and bone density -- will be treatable, probably through a combination of drugs, cell replacement, physical training and electronic aids.

    And tentative but encouraging signs are emerging in the quest for the ultimate goal: restoring function to paralysed limbs.

    "This is an enormously complicated, but we do believe solvable, problem," said Susan Howley, vice-president of research at the New Jersey-based Christopher and Dana Reeve Foundation for paralysis.

    "Some of the best and brightest people at work in the neurosciences are thinking about spinal cord injury repair, and working on it. There is tremendous hope," she told AFP.

    Paralysis, full or partial, happens when a message from the brain gets lost on its way to the muscles, blocked by illness or damage to the spinal highway.

    As recently as 20 years ago, researchers focused not on a cure, but simply on making the person comfortable.

    "There was a belief that you are born with a certain number of neurons and when they die, they die, the dogma was that you cannot repair" the damage, said Mark Bacon, research director at Spinal Research, a UK charity.

    That thinking has been swept away, although the available options remain unchanged: the only licensed treatment is physical rehabilitation, which is useful but limited.

    In the lab, though, extraordinary experiments are taking place.

    These include cell replacement and regeneration, spinal scar-tissue removal, electric muscle stimulation and brain-computer connections.

    Some are in clinical trials -- the long process of vetting a new drug or medical technique for safety and efficacy.

    Hopeful of a breakthrough

    One promising but controversial innovation involves replacing or reinvigorating dead or damaged central nervous system cells using embryonic stem cells.

    "We are hopeful of a breakthrough," said Martin McGlynn, president of Newark-based StemCells Inc, which is implanting stem cells directly into the spines of paralysed trial patients.

    "(...) [T]his therapy has the potential to provide a long-lasting benefit with the potential to also significantly reduce the overall health care burden."

    Though promising, observers like Howley point out that stem cell research, like most other therapies, is in its infancy.

    "We need to better understand which are the best cells to be transplanted and which kind of stem cell should be optimally used; how well do the transplanted cells actually integrate into the central nervous system and become functioning; and how to contend with the scar at the lesion site," she said.

    The last three years have also seen exciting developments in electrical spinal stimulation.

    The work bypasses attempts to link the brain to muscles, instead using electrodes to jolt the relatively autonomous nerve networks of the lower spine directly.

    Some experiments have shown paralysed people stand on their own two feet and regain limited movement, though apparently no feeling.

    Some individuals regained varying degrees of bladder control and sexual function -- "a patient population for whom it was always believed that nothing could be done", Howley noted.

    Among the most thrilling work, though expensive and invasive, is in brain-computer interfaces -- using electrodes to read the intent of the brain to make a movement and relaying that message to muscles to enact it.

    "The brain-machine interface is a promising field, but we are taking the first, faltering steps," said Nathanael Jarrasse, a robot specialist at the French National Centre for Scientific Research (CNRS).

    A common and tragic problem

    As many as 500,000 people per year suffer spinal cord injuries -- one of the main causes of paralysis, according to the World Health Organisation (WHO).

    What are the chances of a cure?

    "It's obvious there isn't going to be a single magic bullet," said Howley.

    "The way we have to think about fixing spinal cord injury is picking the low-hanging fruit first, as we continue to work towards fixing the more difficult, long-term problems."

    Experts believe the answer will be a combination of treatments.

    Doctors would likely administer a "neuroprotectant" drug as soon as possible after injury to reduce the death of precious nerve cells, said Bacon.

    This could be followed by a drug to encourage the rerouting of broken nerve connections. Next could be cell replacement therapy to reverse whatever damage could not be stopped.

    Finally, the patient may be helped with electrical stimulation to restore some automatic functions and computer-brain interfaces to wield a still useless limb.

    "We are at the beginning of the journey in the same way cancer was 20 or 30 years ago, where we have the prospects of treatments that will improve the outcome, and with time we will refine those," said Bacon.

    AFP
    "I'm manic as hell-
    But I'm goin' strong-
    Left my meds on the sink again-
    My head will be racing by lunchtime"

    <----Scott Weiland---->

  10. #10
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    Very encouraging news coming now.

    Can this epidural therapy cure bladder bowel sexual function in lower lumbar injuries also?

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