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Thread: Dental Pulp Stem Cell Vid

  1. #1

    Dental Pulp Stem Cell Vid

    http://www.bu.edu/nerscic/consumer-e...lp-stem-cells/

    Any thoughts on these as an upcoming clinical source of cell replacement?

  2. #2
    Quote Originally Posted by Chaz19 View Post
    http://www.bu.edu/nerscic/consumer-e...lp-stem-cells/

    Any thoughts on these as an upcoming clinical source of cell replacement?
    Dental pulp is interesting. Several groups that I have helped train are testing these cells in Taiwan and the results are credible. We will need to work out a protocol for isolating and testing the cells under GMP (good manufacturing practice) conditions. If these cells provide a source of neural stem cells, we will test them in our lumbosacral spinal cord injury model. They are still two or three years from clinical trial unless a company gets involved and invests in developing the GMP protocols and a laboratory to extract, expand, and differentiate the cells, as well as pay for the preclinical and clinical trial. Wise.

  3. #3
    Quote Originally Posted by Wise Young View Post
    Dental pulp is interesting. Several groups that I have helped train are testing these cells in Taiwan and the results are credible. We will need to work out a protocol for isolating and testing the cells under GMP (good manufacturing practice) conditions. If these cells provide a source of neural stem cells, we will test them in our lumbosacral spinal cord injury model. They are still two or three years from clinical trial unless a company gets involved and invests in developing the GMP protocols and a laboratory to extract, expand, and differentiate the cells, as well as pay for the preclinical and clinical trial. Wise.
    Wise

    What would be an intervention for lower level injuries? Neural stem cells to replace damaged motor neurons and locomotor training to relearn walking? Or would you be including anything else?

    Thanks, Wes

  4. #4
    Quote Originally Posted by wesmaister View Post
    Wise

    What would be an intervention for lower level injuries? Neural stem cells to replace damaged motor neurons and locomotor training to relearn walking? Or would you be including anything else?

    Thanks, Wes
    You have to replace damaged motor neurons, get them to grow their axons out the ventral roots to the muscles, make synapases with muscle, get descending axons in the brain to connect with motoneurons and interneurons in the spinal cord, and reorganize the reflex circuits to allow the legs to walk.

    wise.

  5. #5
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    Wise will all this happen with neural cells only or with some combination?

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