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  1. #37
    Related to this discussion is whose article abstract is below. We see discussion/results of ChABC+stem cell testing in UK/China.

    Combination treatment with chondroitinase ABC in spinal cord injury?breaking the barrier
    Rong-Rong Zhao, James W Fawcett
    Brain Repair Centre, University of Cambridge, UK
    Corresponding author: James W Fawcett. E-mail:

    ? Shanghai institutes for Biological Sciences, CAS and Springer-Verlag Berlin Heidelberg 2013

    After spinal cord injury (SCi), re-establishing functional circuitry in the damaged central nervous system (CNS)
    faces multiple challenges including lost tissue volume, insufficient intrinsic growth capacity of adult neurons,
    and the inhibitory environment in the damaged CNS. Several treatment strategies have been developed
    over the past three decades, but successful restoration of sensory and motor functions will probably
    a combination of approaches to address different aspects of the problem. Degradation of the
    sulfate proteoglycans with the chondroitinase ABC (ChABC) enzyme removes a regeneration
    barrier from the
    glial scar and increases plasticity in the CNS by removing perineuronal nets. its mechanism
    of action does
    not clash or overlap with most of the other treatment strategies, making ChABC an attractive
    candidate as a
    combinational partner with other methods. in this article, we review studies in rat SCi models
    using ChABC
    combined with other treatments including cell implantation, growth factors, myelin-inhibitory
    molecule blockers,
    and ion channel expression. We discuss possible ways to optimize treatment protocols
    for future combinational
    studies. To date, combinational therapies with ChABC have shown synergistic
    effects with several other
    strategies in enhancing functional recovery after SCi. These combinatorial
    approaches can now be developed
    for clinical application.
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