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Thread: The Technology is HERE: Neural Stem Calls + Fibrin Protein = Bridge Across SCI

  1. #1
    Senior Member ColonusFan's Avatar
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    Lightbulb The Technology is HERE: Neural Stem Calls + Fibrin Protein = Bridge Across SCI

    Paul Lu in Mark Tuszynski's Laboratory has taken 1) Neural Stem Cells combined the cells with 2) a Fibrin Protein 3) injected the assembly into Laboratory Rats with completely severed spinal cords and the results: 4) Remarkable, long axon neural cell growth across the injury site location.

    Here is a link to the paper: ---> http://www.sciencedirect.com/science/article/pii/S0092867412010185

    http://ars.els-cdn.com/content/image...010185-gr1.jpg

    I found it after seeing Stem Cell Universe hosted by Stephen Hawking on the Science Channel. After a BUNCH of Internet investigation it looks like we might be a HUGE leap towards a "Cure for Spinal Cord Injury".

    Will some one please confirm that this is not Internet FICTION?

    Also if any one knows of Clinical Trials for this procedure PLEASE POST!

    Can this be the drum beat towards a SCI Cure that we have been wishing and wanting for?

  2. #2
    Senior Member NWC4's Avatar
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    Dr Young,

    Will you please comment on this paper?

  3. #3
    Quote Originally Posted by ColonusFan View Post
    Paul Lu in Mark Tuszynski's Laboratory has taken 1) Neural Stem Cells combined the cells with 2) a Fibrin Protein 3) injected the assembly into Laboratory Rats with completely severed spinal cords and the results: 4) Remarkable, long axon neural cell growth across the injury site location.

    Here is a link to the paper: ---> http://www.sciencedirect.com/science/article/pii/S0092867412010185

    http://ars.els-cdn.com/content/image...010185-gr1.jpg

    I found it after seeing Stem Cell Universe hosted by Stephen Hawking on the Science Channel. After a BUNCH of Internet investigation it looks like we might be a HUGE leap towards a "Cure for Spinal Cord Injury".

    Will some one please confirm that this is not Internet FICTION?

    Also if any one knows of Clinical Trials for this procedure PLEASE POST!

    Can this be the drum beat towards a SCI Cure that we have been wishing and wanting for?
    ColonusFan, I saw the same show(Stem Cell Universe) on The Science Channel hosted by Stephen Hawking and came away with lots of hope & excitement! As far as confirmation, well its there on video, both Dr Lu and Dr Tuszynski explaining/describing the promising research. Good stuff!
    "I'm manic as hell-
    But I'm goin' strong-
    Left my meds on the sink again-
    My head will be racing by lunchtime"

    <----Scott Weiland---->

  4. #4
    The acute rats mean BBB score reached a level of seven out of twenty one, indicating movement about each joint of the hindlimb, in contrast to minimal movement, if any, in lesioned controls.

    https://vimeo.com/55791123

    https://vimeo.com/56616810

  5. #5
    Senior Member lunasicc42's Avatar
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    seven out of twenty one?
    "That's not smog! It's SMUG!! " - randy marsh, southpark

    "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


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  6. #6
    Quote Originally Posted by ColonusFan View Post
    Paul Lu in Mark Tuszynski's Laboratory has taken 1) Neural Stem Cells combined the cells with 2) a Fibrin Protein 3) injected the assembly into Laboratory Rats with completely severed spinal cords and the results: 4) Remarkable, long axon neural cell growth across the injury site location.

    Here is a link to the paper: ---> http://www.sciencedirect.com/science/article/pii/S0092867412010185

    http://ars.els-cdn.com/content/image...010185-gr1.jpg

    I found it after seeing Stem Cell Universe hosted by Stephen Hawking on the Science Channel. After a BUNCH of Internet investigation it looks like we might be a HUGE leap towards a "Cure for Spinal Cord Injury".

    Will some one please confirm that this is not Internet FICTION?

    Also if any one knows of Clinical Trials for this procedure PLEASE POST!

    Can this be the drum beat towards a SCI Cure that we have been wishing and wanting for?
    This was posted last Sunday night on the Stem Cells Assay's Blog: http://stemcellassays.com/2014/02/lo...ic-masses-nsc/

  7. #7
    Quote Originally Posted by NWC4 View Post
    Dr Young,

    Will you please comment on this paper?
    I had commented extensively on this paper on CareCure when it first came out. When I have some time, I will go search this site for the posts. I had pointed out Paul Lu's results when refuting Jerry Silver's claim that glial scars stop axon growth. Paul showed many axons that grew across the transection site without doing anything to remove the gliosis that surrounded the transection site.

    In 2011 and 2012, Paul Lu published two very important papers. One of them was this one where he transplanted neural stem cells and showed that the neural stem cells sent axons both rostrally (towards the head) and caudally (towards the bottom end of the spinal cord), made synapses with many neurons above and below the injury site. The rats showed significantly better BBB scores but the BBB scores were not in the walking range. The BBB score is a 0-21 point scale where 0 means no movement in the legs and 21 means normal walking. A BBB score of 10 indicates a rat that can stand but not step. A score of 7 means that the rat is not able to stand but can move 2 of the 3 joints of the legs. The rats were not walking. By the way, the transplanted neural stem cells were connecting, not the host axons. But Paul Lu showed that the rats had descending axons from the brain and connected to the neurons produced by the transplanted neural stem cells.

    The second paper was one in which Paul Lu transplanted mesenchymal stem cells to bridge the injury site, injected cAMP into the brainstem (to "push" the axons to grow), and used viruses to transfect cells below the injury site to express brain-derived neurotrophic factor (to "pull" the axons to grow down the spinal cord). This study showed remarkable regeneration of thousands of axons across the injury site but the rats showed very little or no significant improvement in BBB scores.

    Last October, Paul Lu presented these and other results at the Neural Regeneration meeting in Shenyang. I have posted about this meeting before, indicating that it was one of the best spinal cord injury meetings that I have ever helped organize. Jerry Silver, Jim Fawcett, and many other very good scientists were there. It has had a lot of influence on my thinking. Again, as soon as Steven Edwards gets this site up and going (properly indexed and showing all the posts), I will look for these posts and link them.

    Wise.
    Last edited by Wise Young; 02-11-2014 at 06:55 AM.

  8. #8
    Quote Originally Posted by lunasicc42 View Post
    seven out of twenty one?
    Acute. This isn't a chronic study.

  9. #9
    Senior Member lunasicc42's Avatar
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    Quote Originally Posted by GRAMMY View Post
    Acute. This isn't a chronic study.

    Do you think, or do you have your eye on anyone that could do better in a chronic setting... Who's the one to watch?
    "That's not smog! It's SMUG!! " - randy marsh, southpark

    "what???? , you don't 'all' wear a poop sac?.... DAMNIT BONNIE, YOU LIED TO ME ABOUT THE POOP SAC!!!! "


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  10. #10
    Senior Member Tbone57's Avatar
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    check out http://aprilals.com neural stem cell phase II in ALS patients

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