Neural plasticity after human spinal cord injury: application of locomotor training to the rehabilitation of walking [In Process Citation]


Neuroscientist 2001 Oct;7(5):455-68 (ISSN: 1073-8584)

Harkema SJ [Find other articles with this Author]
Department of Neurology and the Brain Research Institute, University of California, Los Angeles 90095-7147, USA.

Recovery of locomotion has been considered unattainable following a clinically complete or severe incomplete spinal cord injury even after conventional therapy. However, the locomotion of spinal animals can be improved by training that provides complex temporal patterns of sensory information related to stepping that is interpreted by the spinal cord. This review discusses the evidence that suggests human spinal networks can integrate and interpret complex sensory signals to produce functional efferent output and adapt to repetitive training. Locomotor training, a new rehabilitative approach, is based on principles that promote the movement of limbs and trunk to generate sensory information consistent with locomotion to improve the potential for the recovery of walking after neurologic injury.

Language: English
MEDLINE Indexing Date: 200110
Publication Type: Journal Article
PreMedline Identifier: 0011597104
Unique NLM Identifier: 21480675
Journal Code: IM