Page 4 of 11 FirstFirst 1234567891011 LastLast
Results 31 to 40 of 109

Thread: W2W - Boston

  1. #31
    Quote Originally Posted by t8burst View Post
    I imagine doing a bowel program/cathing a group of monkeys for an extended period of time would be quite expensive. Where with humans they can do it themselves (well some of them)
    God gave us foleys and agressive laxatives.....

  2. #32
    I've seen Wise post on rats, but my concern were more about large mammal vs clinic trial. Are they so expensive it's better to skip them if there not safety concerns?
    Debating on CareCure is like participating in the special-olympics. You may win, but you're still disabled.

  3. #33
    Quote Originally Posted by Sue Pendleton View Post
    Speaking privately to several researchers over the years I have found few wish to advertise if they have done any primate studies due to PETA. I have no idea what therapies the FDA requires primate studies on and whether that information is open to public scutiny because of security concerns. I do know that innocent people have been injured by acts against institutions that do animal research, even when the research can also help the animals, by extremist groups. IOWs, just because it's not in a press release that doesn't mean it hasn't been done.
    Interesting point... an incident like that actually happened recently.
    Animal-rights activists wreak havoc in Milan laboratory

    University says loss of animals and lab records may ruin years of work on psychiatric diseases.

    Activists occupied an animal facility at the University of Milan, Italy, at the weekend, releasing mice and rabbits and mixing up cage labels to confuse experimental protocols. Researchers at the university say that it will take years to recover their work.
    SOURCE

  4. #34
    Even me asking for larger mammal studies would be jumping the gun.

    We need to see success in a rat first. Not success in an acute or incomplete model. We need to see success in a chronic and complete injury model. Until that happens, clinical trials (for chronic & complete sci) would be a waste of money and time and would be a huge distraction.

    Where are the chronic & complete rat studies? For any therapy?

  5. #35
    Quote Originally Posted by paolocipolla View Post
    See this thread: http://sci.rutgers.edu/forum/showthread.php?t=201643

    @ KK11 IMO Wolfram Tetzlaff is a great example of how SCI research works... I wish it were a joke, but the truth is most SCI researchers are not even trying to cure us... and I wonder why SCI orgs and advocates have not take action yet to fix that by restricting money to chronic SCI.

    Big SCI community failure.

    Paolo
    What is the background on Tetzlaff, I feel like I am missing something here.

  6. #36
    Quote Originally Posted by NowhereMan View Post
    Even me asking for larger mammal studies would be jumping the gun.

    We need to see success in a rat first. Not success in an acute or incomplete model. We need to see success in a chronic and complete injury model. Until that happens, clinical trials (for chronic & complete sci) would be a waste of money and time and would be a huge distraction.

    Where are the chronic & complete rat studies? For any therapy?
    Some studies are attached, I don't have the complete updated list of research studies performed.

  7. #37
    Quote Originally Posted by Jim View Post
    Some studies are attached, I don't have the complete updated list of research studies performed.
    I've been through that list before. None are chronic & complete (nor were the results robust). The clinical trial is in progress so it is useless to argue about whether the preclinical studies were adequate. I'm more talking about the researchers at w2w.

    a) they should be doing their work in chronic & complete models. (in addition to what they are currently using).

    b) we should not be obsessed with when they are going to start clinical trials until they can prove efficacy in chronic & complete animal models.
    Last edited by NowhereMan; 05-21-2013 at 10:10 PM.

  8. #38
    Quote Originally Posted by cripwalk View Post
    What is the background on Tetzlaff, I feel like I am missing something here.
    See this:

    http://www.youtube.com/watch?v=6XOH8H0tz-s

    Tetzlaff is the first who tries to answer the question.

    Paolo

  9. #39
    Quote Originally Posted by NowhereMan View Post
    I've been through that list before. None are chronic & complete (nor were the results robust). The clinical trial is in progress so it is useless to argue about whether the preclinical studies were adequate. I'm more talking about the researchers at w2w.

    a) they should be doing their work in chronic & complete models. (in addition to what they are currently using).

    b) we should not be obsessed with when they are going to start clinical trials until they can prove efficacy in chronic & complete animal models.
    I agree 100% with point a and b.

    Paolo

  10. #40
    Quote Originally Posted by NowhereMan View Post
    We need to see success in a rat first. Not success in an acute or incomplete model. We need to see success in a chronic and complete injury model. Until that happens, clinical trials (for chronic & complete sci) would be a waste of money and time and would be a huge distraction.
    The premise of this argument is false.



    First, from a medical perspective, why would you wait for a complete chronic model to show efficacy before testing on humans once safety has been established? Most of the SCI population is incomplete, and most of the animal and human data show that there are therapies available that show tremendous potential to improve function and quality of life in these people. Most drugs/therapies on the market for cancer, AIDS, MS, and countless other conditions do not cure the diseases, but both prolong and improve the quality of patients’ lives. Phase one testing is done on complete injuries to ensure that patients will incur no additional loss of neurological function. Would you deny these people any potential improvement in their lives because you feel the evidence is not strong enough?



    Second, from a business perspective, the goal is to bring a product to market that will generate revenue. Ampyra is a perfect example. Does it cure MS? No. Does it help people with SCI? Not much. But, for some people with MS, it greatly improves the quality of their lives. And it turned Acorda into a billion dollar company.


    Moreover, once one therapy shows some proven efficacy, other companies will rush to get improved therapies to market. Viagra is another example of this. Other companies improved it and are continuing to work on it in hopes of capturing some of that market share.


    These are neither wasteful nor distractions. They are steps in a process.

Similar Threads

  1. Boston Bombing
    By nrf in forum Life
    Replies: 203
    Last Post: 04-29-2013, 08:17 PM
  2. Where to seek PCA in Boston?
    By postit in forum Caregiving
    Replies: 14
    Last Post: 03-13-2008, 05:49 PM
  3. Boston
    By mckeownp in forum Cure
    Replies: 0
    Last Post: 06-04-2006, 07:49 AM
  4. Boston meet up?
    By Lewis in forum Life
    Replies: 22
    Last Post: 02-09-2006, 11:24 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •