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Thread: Human trials offer hope those with paralysis will walk again

  1. #1
    Senior Member mj23's Avatar
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    Human trials offer hope those with paralysis will walk again

    Human trials offer hope those with paralysis will walk again

    BOSTON —A device developed by a Cambridge company could one day help those faced with paralysis to walk again.

    It's hard to believe that 19 years ago an accident left Frank Reynolds paralyzed.
    Luckily, it was temporary.

    Today his company, Cambridge-based InVivo Therapeutics, has developed a device to give others with severe spinal cord injuries a chance to leave their wheelchairs behind.

    "Say you had a four-lane highway, a major accident. All lanes are blocked. That's what happens with a spinal cord injury. They might not be able to move, they may not be able to feel. But they haven't gone through the 21-day scarring process. So we want to get in and open up some of those lanes and allow the spinal cord to reorganize itself," said Reynolds.

    In doing so, some of the spinal tissue regenerates. It's done with a device called scaffolding, which is inserted directly into the spinal cord.

    "Then, the tissue that hasn't scarred yet has something to hold on to. It's literally like holding on to a life preserver to cells out there that are about to get washed away," he said.

    The scaffolding has shown excellent results in injured monkeys. A video shows a monkey dragging his leg at the beginning of the study. Five weeks after treatment, he is fully recovered.

    Now, the FDA has approved the scaffolding for human trials.

    "Our human central nervous system is much more advanced than monkeys. But it's 99 percent similar. We think humans will recover faster," said Reynolds.

    Depending on the extent of the injury, one of four scaffolds will be inserted in the spinal cord. It takes all of a minute.

    Walking away from a wheelchair is the ultimate goal. But Reynolds said regaining any function can change a person's quality of life dramatically.

    "If we can get someone to move a finger, a toe, anything that would help them control the environment would be helpful."

    All 44 monkeys involved in the trial are fully recovered from paralysis.

    The human trials will begin in a matter of months.

    Five patients will participate in the first trial, some of them at Mass General Hospital.

    click link for video

    Read more: http://www.wcvb.com/health/Human-tri...#ixzz2QGQXnX9G
    C-5, 6 SCI. Took about 6 months to walk. Walking full time. Without any assistance since Nov. 2003 and will make a full recovery

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    Interesting.

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    Good news! Can't wait for them to say 44 humans have fully recovered!!

  4. #4
    IMO the title to this is so miss leading.

  5. #5
    I´ve read those headlines in my young 1,5 years SCI career about 50 times......And when you read it its everytime the same. Chronics are busted So who f&%$§" cares about us? Us who they are talking to and giving hope to at all those great meetings and stuff like that?! Im slowly loosing my cool about this all. They have to care about us and this isnt happening. Im sorry for all of those who are getting injured in the future but if we can help chronics then we can help acutes.

    THE BIG DEAL IS IT TO GET SOMEONE OUT OF THE WHEELCHAIR AND NOT TO SAVE THEM FROM IT!!!!!!!!!!!!!

    When you guys are with me then support me!!
    Last edited by KK11; 04-13-2013 at 03:29 PM.

  6. #6
    Quote Originally Posted by KK11 View Post
    I´ve read those headlines in my young 1,5 years SCI career about 50 times......And when you read it its everytime the same. Chronics are busted So who f&%$§" cares about us? Us who they are talking to and giving hope to at all those great meetings and stuff like that?! Im slowly loosing my cool about this all. They have to care about us and this isnt happening. Im sorry for all of those who are getting injured in the future but if we can help chronics then we can help acutes.

    THE BIG DEAL IS IT TO GET SOMEONE OUT OF THE WHEELCHAIR AND NOT TO SAVE THEM FROM IT!!!!!!!!!!!!!

    When you guys are with me then support me!!
    The big problem is that researchers and SCI orgs, which are driven by researchers, still focus mainly on saving people from w/c rather than getting people out of w/c as it is still cosidered too ambitious at this stage.

    I have proposed few actions in the past to change that, but didn't have much success.
    What do you propose?

    Paolo

  7. #7
    Quote Originally Posted by Barrington314mx View Post
    IMO the title to this is so miss leading.
    So is Miss Transgender USA...

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    The trouble is regardless of which country it is, those that have been in the chair for more than two years from their injury have been unable to do much in physical activity’s and careers.

    So if a chronic is cured say after twenty years and has done nothing or been able to do anything will be seen as drain on Government resources in regards to unemployable, they are also more than likely take longer to regain function, so therefore I can to a point understand why they focus cures on acute.

    and no i am not happy with that

  9. #9
    Hi have sent emails to try and find out criteria for the trial and of course no response any suggestions?

  10. #10
    With this approval, InVivo intends to commence a first-in-man clinical study in the next few months that will test safety and performance of its biopolymer scaffold in five acute patients. The Company expects the study to occur over approximately 15 months. Over the next month or so, they plan to finalize the details of the study, and expect to have all data to the FDA by the end of 2014.

    They probably don't have all the details lined up yet for the 5 acute patients they plan to recruit.

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