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Thread: Geron Announces Publication of Studies Showing Oligodendrocyte Progenitors Derived From Human Embryonic Stem Cells Induce Functional Recovery After Spinal Cord Injury

  1. #1
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    Geron Announces Publication of Studies Showing Oligodendrocyte Progenitors Derived From Human Embryonic Stem Cells Induce Functional Recovery After Spinal Cord Injury

    Geron Announces Publication of Studies Showing Oligodendrocyte Progenitors Derived From Human Embryonic Stem Cells Induce Functional Recovery After Spinal Cord Injury
    Source : Moneyplans.net Archives

    Geron Corporation (Nasdaq:GERN) announced today the publication of studies showing that oligodendrocyte progenitors, differentiated from human embryonic stem cells (hESCs), produce functional improvements in rats with spinal cord injuries. These studies provide proof of concept for the therapeutic potential of differentiated hESCs in the treatment of neurological disorders such as spinal cord injury.

    In the May 11 issue of the Journal of Neuroscience, Dr. Hans Keirstead and his colleagues from the Reeve Irvine Research Center at the University of California, Irvine published studies demonstrating that hESC-derived oligodendroglial progenitor cells (OPCs) could be delivered to the injured spinal cord in rats and resulted in functional improvement in locomotion as well as histological evidence of spinal cord repair.


    Oligodendrocytes are normal cellular components of the central nervous system that wrap and insulate neurons in a process known as myelination. Such myelin wrapping enables efficient electrical transmission in neurons in the central nervous system. After spinal cord injury and the subsequent inflammatory response, native oligodendrocytes at the injury site die, leading to myelin destruction and consequent impaired electrical conduction even in those neurons that may have survived the initial injury. Demyelination of neurons leads to both sensory and motor deficits.

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  2. #2
    A different therapy will be needed for chronic injuries.

  3. #3
    Chris2, it is important not to jump to conclusions based on lack of data. Just because a study shows that embryonic stem cells are beneficial in subacute spinal cord injury does not mean that it will not work on chronic spinal cord injury. Wise.

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