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Thread: Dr.Kleinbloesem

  1. #401
    MKA, thanks for sharing. I would also like to point out that Dr. K is an editor for a UK medical Journal. It really bothers me how sometimes on this site they borrow Phraseology from other threads to spew mistrust. Somewhere I heard about Dr. K's procedure being referred to with "why all the secrecy" as if they were trying to put this in the same class as cool article.

    Hey, I don't come here to make friends and I speak from the heart-But there are those here who try to diminish your point of view, Sigh, how sad.
    Don't ignore the Reeve Legacy, Remember he and Dana supported open research and fought hard for ESCR


    Support H.R. 810

  2. #402
    Thanks MKA keep us posted. maybe I'll see you in Sept. You can show me around the city!!

  3. #403
    Senior Member
    Join Date
    Mar 2004
    Warner Robins, GA, US

    Thank you so much for sharing your story with us! We can sure use the positive input!

    Please keep us informed of any further development.
    gretchen 1

  4. #404

    Thumbs up

    thanks MKA all your research is appreciated.

  5. #405
    Hello, MKA. Thank you for the information that you have provided. I assume that you are referring to Dr. Yasargil (he is one of the most prominent neurosurgeons in the world, having pioneered the use of the microscope for neurosurgery and is indeed much respected). I know him. Last I heard, he has retired in New Orleans but still teaching. I know and respect Turkish neurosurgeons, their skill and experience. I don't know Dr. H. Deda personally but he has published in the field and the Ankara Hospital is a very well-established and respected hospital. I think that it might be useful for me to try to summarize the information about the procedure to date (my summary in regular type and my comments in italics):

    1. The bone marrow cells are "extracted" and frozen (€1995 covers the cost of extraction and storage for 10 years).
    If true, this is a reasonable price, in my opinion. It is not clear where this is done, perhaps in Turkey.

    2. A pre-operative MRI or CT-scan of the entire spinal cord is required. Somatosensory evoked potential (SEP) and electromyograms (EMG) were also mentioned.
    This is reasonable information to be requesting for screening..

    3. The procedure for growing the cells is confidential, developed by Cells4health, that is "able to concentrate the cells [from 200ml to 2 or 3 ml] which is not available everywhere", and being patented.
    I am not sure that I understand this description. When one spins bone marrow stem cells down, this usually results a 60% reduction in volume, assuming a hematocrit of 40%. So, the suggestion that Cells4Health has some procedure for concentrating the cells to 1% of original volume not only does not make sense but is impossible. Perhaps it is a language problem but one possibility is that he means that they have a cell-sorter or method that is selecting 1-2% of the cells for transplanation. I suspect that this is what he means, that he is talking about cell-sorting or some method selecting the cells for transplantation, and not "concentrating" the cells. By the way, if he is referring to cell-sorting, this is being done in many places. The question is what they are sorting for and how they know that the cells that they are sorting for are stem cells.

    5. The cells are transplanted into the spinal cord through "30 or 40 micro-injections take place : above, below and around the injury."
    It would be interesting to know the volume of the injections and the number of cells per injection. The information is consistent, however, with 50 microliter injections. If he is injecting making 30-40 50-microliters injections, this would add up to 1.5 to 2.0 ml of cells being injected into the spinal cord. Although Dr. Kleinbossoem does not say the size of the laminectomy and whether the dura is excised, this description alone would indicate that they are carrying out a laminectomy that exposes the spinal cord injury site, as well as some cord above and below the site. Since most injury sites encompass at least one segmental level, this would imply a laminectomy that exposed at least 3 spinal cord segments. They are very likely to be incising the dura and then repairing with sutures. It might be useful to ask whether duroplasty will be done and what material will be used.

    6. There is apparently no exclusion criteria of patients based on injury level, severity, time after injury. The waiting list is short (3/4 month).
    I suspect that they probably have some exclusion criteria based on health of the patient, i.e. diabetes, pregnancy, etc. It is not clear whether they will accept ventilator dependent patients. It seems that they are not ruling out patients with lower thoracic or conus injuries. I assume that they are not doing patients with cauda equina injury but it may be useful to confirm this.

    7. The location and neurosurgeon doing the surgery is still uncertain. Professor Deda is mentioned to have stopped the trial because of a complaint by a Belgian professor. This seems to be temporary because Dr. Kleinboessom says that the procedure will "very soon restart in Turkey". There are plans to start the procedure in Western Europe in September 2005, planning about 3 patients per day per center. France and USA may be delayed for regulatory reasons.
    It seems that a complaint by a Belgian Professor who is apparently critical of the procedure prompted Ankara Hospital to review the procedure. Dr. Kleinbossoem appears is confident that the trial will restart soon.

    8. About 9 patients have been done to date. All were Asia A. Two are able to walk without braces/calipers/walker. One is able to walk with calipers. One did not recover very much because of a "transected spinal cord". The remainder 5 were done recently and their data will be included.
    There is not enough information here to comment. But, if two ASIA A patients have recovered to independent locomotion, that would be significant, in my opinion.

    9. The whole procedure including extraction of the bone marrow cells, flight to Ankara, surgery, and hospitalization apparently is €16,000.
    This seems to be a very reasonable cost.

    10. Rehabilitation is available at the "Rebel" Rehabilitation Center in Netherlands but patients can choose other places in Switzerland (Balgrist in Zurich, for example).

    Please do not hesitate to comment, correct, or add to this description. I will keep correcting it as I see errors or other information that is worthwhile adding.


    Quote Originally Posted by mka
    Hi All,
    I follow this site till September 2003, after my brothers accident. Some of you may remember or not. My brother is SCI C3-5 and he is paralyzed from his neck down.

    I have read all the posts in this thread from the very beginning. For the last 5 months I quite to read Care cure.

    Regarding the procedure applied by Dr.Kleinblose and Dr.Deda I would like you to share with you the followings;
    - I could not get in touch with DEDA, I did not see any of the patians that has received the procedure. But I am trying hard.
    - My father is also a doctor. so we are a little bit more familiar with doctors and hospitals. first Ankara University Hospital is the most important hospital in Turkey and DEDA is a doctor in this hospital. I can only say that DEDA is a very well known doctor in Turkey. He could not be a part of fraud operations.
    - Some of you may know Prof.Dr. Yasar Gazigil he is the most reliable and well known neurosurgent in the world. Dr. Yasar and Deda are very close friends and apply some operations together in the Bayindir Hospital where Deda was working as private. In Turkey health sector is a little bit confusing some of Doctors can both work in Governmental Hospitals for just academic career and in the both hand he or she can also work in private hospital to earn a little bit more than governmental hospital.
    - Our doctor is a different doctor therefore we could not meet with deda and we are also waiting for the results of Deda but up to date what we here is very reliable. (sorry no reliable data for you). why we could not meet deda is our doctor is deda's opponent.
    - up to date there are some financial issues regarding to operation. therefore they could not published the outcomes of the procedure. an approval has been waited from the european insurance companies. at least it is told me so.
    so far no more news but as I said before our investigations are on going. I will inform you about the upcoming progress.

    But I must said that Ankara University Hospital and Dr.Deda are not just somebody and an institute. The informations that all of us share is 99% true.
    Sorry for poor English...
    Best Regards....
    Wilfried had posted Corinne Jeanmaire's notes validated by Dr. Kleinbloesem: I italicized the answers that were presumably from Dr. Kleinbossoem:

    JUNE 15TH, 2005- JUNE 25TH, 2005

    Written by : Corinne Jeanmaire - - SCI patient since 2001 .
    Validated by : Dr Kleinbloesem -
    Main focus : Effects of Dr Kleinbloesem's procedure on SCI

    1.1-Summary of SCI patients having had surgery so far - profile - overview of results
    To date, 9 SCI patients got the surgery. 4 of those had surgery in February 2005. The 5 remaining patients had surgery later and results should be checked later.
    Overview of results : see annex 1. [first 4 SCI patients]

    1.2-Are those SCI patients [see annex 1] still progressing ? Yes .

    1.3-Is more progress still expected for those ? How long after procedure should progress start and how long after the procedure should it continue
    It is expected that evolution can go on for 1 year after surgery, although the pace of improvement is expected to decrease over the months.

    1.4-Is progress conditional upon intensive rehabilitation after the procedure ?
    Yes intensive physio-therapy is necessary in order to maximize the effects of the transplant.

    1.5-Do you have any plan to set up an intensive rehab program in Turkey or anywhere else ?
    For the time being, rehabilitation in the Netherlands can be done in co-operation with the Rebel sport center. Furthermore, the possibility to have the procedure, up to and including rehabilitation is also looked at in extreme orient, eg in Dubai.

    1.6-Could a combination with other therapies such as lasertherapy[eg. Laserponcture, in France] help maximize the effect of the procedure ?
    Yes, most probably laser could be combined with intensive physiotherapy and maximize results.

    1.7-Would it make sense to apply a loco-motor training [suspended treadmill ambulation] immediately after the surgery or long after ? Or is a traditional physio-therapy more suitable ?
    These questions need to be discussed with a specialist in the area of loco- motor training.

    1.8-What are the effect of the procedure on bowels and bladder control ?
    So far, the SCI patients with positive effect from the procedure have recovered sensation w.r.t bowel and bladder. They do not have control yet. But some progress is still expected in that field.

    1.9-Can we expect positive effect on neurological pain / other pain ?
    Yes, some patients could indeed significantly decrease their pain level as well as spasms.

    1.10-What final results can be expected for SCI patients and others ? Are there any irreversible effects of SCI due to time ?
    It is too early to say what the final results will be.

    1.11-Is it possible to establish a structured -online communication with all patients to follow-up progress in a structured and transparent way ?
    That possibility will be looked at. It will first be checked whether the patients are willing to communicate their information and to take the risk of being overwhelmed with questions and phone calls.

    1.12-Is there any follow up of progress after the procedure through Dr Kleinbloesem / other ?
    There is a regular follow-up at the hospital itself. Progress is then discussed with Dr Kleinbloesem

    1.13-How invasive is the procedure ? total anesthesia ?
    The procedure is done with total anesthesia, but a short acting one [propafol] .

    1.14-Are there any specific risks associated to the procedure, eg fever , infection, tumor
    There is no specific risk of infections or fever associated with the procedure. The cells transplanted are the patients' own cells which excludes any reject. Besides, the cell extraction is done in clean rooms and according to highest international standards.
    Tumor risk is also excluded due to the fact that these are the own patient's cells.


    2.1-Chronic vs acute
    Chronic : ok
    Acute : until now, there was no patient's request. The procedure should also work for acute injuries. The results should even be better since the problems of scars and atrophy would not apply. We are willing to try the procedure to acute injury patient if some apply.

    The younger, the better. Among others, the value and the vitality of the cells is better by young people. There is no exclusion due to age. Nevertheless, for an older person [eg 70years old] chances of success are smaller. In any case the cells can be extracted and tested in order to check if a procedure should be applied.

    2.3-Age of injury
    There is no exclusion. Nevertheless, a recent injury is most probably more favourable as deep spinal cord and muscles atrophy issues are less likely.

    2.4-Level of injury
    No exclusion. No differentiation.

    2.5-Asia rating: Asia A/B - Complete/ incomplete injuries / spinal cord compression vs trans-section
    No exclusion with regard to the official Asia rating itself. All patients operated so far were ASIA A before the procedure. Nevertheless, the procedure cannot yet be applied to patients whose spinal cord was trans-sectioned.
    The current procedure and cell treatment does not allow to grow axons. This will most probably be possible in next phases.

    2.6-Will the procedure also apply in the case of spinal cord trans-section later ? How ? When ?
    Yes, in phase 2 and 3. Plans are as follows :
    Phase 1 : Current procedure, for patients with a compressed cord.

    Phase 2 : Expansion of cells. Stem-cells will be turned into precursor cells before administration. We hope to be able to propose such a procedure by end of 2005. [status : in progress]

    Phase 3 : Using a peptide, it is possible to grow axons. We hope to be able to include the use of such peptide in the procedure by beginning of 2006 [status : discussion in progress]
    Such peptide were tried on rats with acute injury [very fresh lesion]. Rats with a trans-sected cord are able to walk normally after 4 weeks. They also regained bladder control.
    Our intention is to apply this procedure starting with chronic injuries, and then, based on the results, to try and convince hospitals to use it for acute injuries.

    2.7-Spinal cord injury further to gun shot
    It is necessary to have an updated MRI /CT scan to check the status of the spinal cord. If there is a total trans-section of the spinal cord through the ball, then the phase 1 procedure would not work. But it could be that the cord is only partially cut by the ball.

    2.8-Maximum length of the lesion [in cm]
    Not applicable

    2.9-What if there is a cyst in the spinal cord ?
    The cyst would not be an exclusion case. The cyst would not be removed unless required. The injection is not expected to alter the cyst in any way.

    2.10-What if the dura was damaged ?
    No problem.

    2.11-Any exclusion for stem cell extraction and process ?
    The only exclusions are related to blood diseases, eg blood cancer, leukemia. In the latter cases, the bone marrow stem-cells cannot be used.

    2.12-Any exclusion due to conclusion from EMG ?
    There is no case of exclusion due to the EMG results only. The EMG is only required as complementary information to the IRM/CT Scan.

    2.13-Can atrophied muscles come back to a functional level even after years without any function, nor stimulation ? [is muscle atrophy reversible ?]
    Until now, there is no evidence of irreversibility.

    2.14-Any exclusion for the procedure ?

    2.15-Can the procedure be applied to specific paralysis cases such as :
    a. Myeline
    The question can only be answered upon receipt of uptodate MRI's/ CT scans.

    b. Tumor in spinal cord
    Such cases would fit better in Phase 2 procedure.

    3.1-What is the cost charged for extracting, processing and freezing the patient’s bone marrow stem cells ?
    1995 EURO is the cost for 1 extraction and 10 year freezing. In one extraction, the patient has enough cells for one procedure. In case of a second procedure, a second extraction is necessary.

    3.2-How long can the stem cells be stored ? in what conditions ?
    There is no limit known to date. The current storage duration is 10 years, but can be renewed as many times as necessary.

    3.3-Is that cost included in the total cost mentioned [14 000 Euro for the procedure - 15 000 Euro including flight from NL to Turkey] ?

    3.4-What is the cost if a second extraction and transplantation is needed [in case of failure or insufficient results]
    Same cost as for the first extraction and the first procedure.

    3.5-Do you give any guarantee w.r.t minimum results ? No

    3.6-Needed input prior to application :
    a. MRI /CT Scan: what if metal will make it difficult to see ?
    The patient might have metal in the body, whereby an MRI should not be made [safety issue]. A CT scan should be made instead. If , however, the metal allows an MRI [eg Titan] : New generation MRI equipment are extremely sharp and should allow a sufficient view, even if there is metal. The best is to indicate what kind of metal and the position of the metal and discuss the issue with the hospital performing the MRI or the CT scan.

    b. What kind of MRI :
    MRI or CT scan should be done in the length [top –down]. Starting point : 10 cm above neurological injury level.

    c. SEP EMG of both legs .
    The EMG enables to evaluate the quality of the muscles and the ability to stimulate the muscles. SEP stands for Somato-sensory Evoked Potentials.

    d. Where to get those MRI/CT SCAN/EMG ?
    It is possible to make MRI/CT SCAN/EMG at Prescan. See Website : - Mail : - Tel: +31 53 4619191 . It is also possible to get those in any hospital / center of your choice.


    4.1-Difference between Dr Kleinbloesem approach and Dr Eva Sykova’s in Cz ? Why do you obtain better results ?

    Czech Republic: Dr. Eva Sykova and colleagues have harvested autologous, bone-marrow stem cells from the iliac bone (i.e., hip) of 17 patients. Within five hours of harvesting, cells were re-introduced into the patient through the vertebral artery (7 cases), intravenously (10 cases), or underneath the cord’s dura membrane (1 case). Eight and nine patients were treated 11-30 days and 2-17½ months after injury, respectively; one patient was treated twice. Four had improved ASIA scores, seven had enhanced neuronal conduction, and the lesions of three were reduced in size as measured by MRI. In general, more benefits accrued when the treatment was done closer to the time of injury. Sykova is now experimenting with stem cells incorporated within a gel matrix, and treating patients with bone-marrow-derived stem cells that have spilled over into blood after drug stimulation. .
    Source : Dr Laurance Johnston –
    Although the same stem cells source is used for extracting the stem-cells, the way of extracting and processing them, as well as the mode of administration can vary a lot and explain totally different results. For example, Cells4health has developed a process to be able to concentrate the cells [from 200ml to 2 or 3 ml] which is not available everywhere. Moreover, C4H injects the cells directly into the lesion.

    4.2-Why are bone marrow stem cells so promising ? Why would they work better than OEG cells ?
    By nature, bone marrow stem cells can help regain movement. OEG cells are suitable to regain sensation.

    4.3-Which process is used w.r.t the stem cells transformation ? is it filtering, multiplication, stimulation ?
    This information is confidential.

    4.4-Did you file any patent for the stem cells transformation ?
    Yes, patent is in progress.

    4.5-In the current procedure [phase 1] : are there any agent introduced in the cells processing ?
    No, what we inject is purely cells. Nevertheless, these are not just stem cells. We also include some intra- and extra-cellular components also found in the bone marrow.

    4.6-Where and how does the injection of the stem-cells take place ?
    30 or 40 micro-injections take place : above, below and around the injury.

    4.7-Is it possible to make some stem cells injection in both sphincters so as to improve the sensation and/or control of B&B ? How would that work ? Has this been done so far ?
    Yes , it is possible. The stem-cells which are not used in the spinal cord, by lack of space, could be injected in the sphincters through a small needle. A better blood supply and a better oxygenation of tissues could foster improvement in that area. This was not done yet in the procedure we carried out so far.
    Recovery of the control of B&B can obviously take quite some time since the necessary muscles are atrophied too. Nevertheless, it is expected to be the next stage after recovery of sensation in that area.

    4.8-What is the current mechanism of recovery ? Is it the remyelination of the existing axons ? or are new axons and neurons being grown /replaced ?What is the effect of the current procedure [phase 1] on the lesion ?
    In the case of MS , there is a remyelination process. For other cases, there is a recovery of the connections which were not working any more. The scar , if any, is dissolved and the new nerves cells replace damaged cells.
    On the 3 SCI patients successfully treated until now, we can observe that the lesion size is halved. This can be seen by comparing MRI before and after the surgery [3 months after surgery].

    4.9-How do you explain that the lesion size is halved ?
    There are new neural cells and the dead cells are replaced.

    4.10-Do the stem cells take time to reach the axons ? to regenerate ?
    The first effects can be felt as of the first week [warm sensation below the level of injury] .

    4.11-Have any trials been made on animals before switching to human trials ? If so, what was the methodology used and what were the results ? Would you be able to share any description of those trials / publication ?
    Yes, numerous trials have been made and described in various publications.

    4.12-Are various approaches tried / is there any variable between different procedure of different patients ?
    No, until now, there is no variable between patients. Only 1 procedure. Placebo procedure is also out of question, for ethical reasons. First an evaluation should take place [based on about 200 patients], and then the procedure will be adapted, based on the results.

    4.13-SCI patient T12 [patient 4] having no effect at all so far : do you know why ?
    CT Scan will be made to re-check what more can be done and a second surgery might be tried if needed. Our assumption is that the surgery did not work because his spinal cord was trans-sectioned.

    4.14-What if the spinal cord is partially sectioned ? Would phase 1 procedure still apply ? What results can be expected in that case ?
    These cases will be handled later, most probably around September. Micro-surgical techniques might help to optimize the effect of stem-cells for the partially sectioned cord. Results cannot be foreseen yet.

    4.15-Do you think that, in some cases , a second surgery [second cell transplant] will be necessary, or do expect all results to be reached through 1 surgery ?
    Nothing is excluded. More time and long term patient follow-up is needed to evaluate the total results.

    4.16 Do you have any intention to co-operate with other doctors /scientists who have already made or plan some experimental trials or research w.r.t SCI ?
    I am open. There was, for example, preliminary discussion with Dr Lima. If judged relevant, a co-operation could be started. No concrete steps have been agreed upon though. It is necessary to get more results from the C4H procedure prior to any such decision.

    Scientists, researchers, are welcome to visit us and see the procedure.


    5.1-It is now known by the SCI community that the few procedures which were planned in the last weeks could not take place. Can you explain what happened ?
    Professor Deda was working for the University of Ankara. That university received a complaint from a Belgian professor. The complaint was mainly driven by his desire to delay or stop our progress rather than by any valid argument. Based on that though, the university of Ankara refused to support Pr Deda any further unless there would be an official text confirming the lawfulness of the procedure. Actually, the procedure is 100% legal. In Turkey, there is not yet any law about stems cells [but there is no law allowing them either].

    5.2-Do you plan to obtain the authorization for Turkey ? By when ? By when do you expect the next procedures to take place ?
    Yes, procedure will very soon restart in Turkey, in another hospital. It is only a matter of weeks. Additional equipment is ordered to be able to handle patients at the alternative location. Name of the hospital will be communicated in due time.

    5.3-Will the procedure take place in other countries ? What will be the available capacity ?
    Yes, we plan a certain number of centers to carry out the procedure: in Western Europe [Expected start up in September 2005 - center will treat spinal cord injury first, and then stroke], in the Middle East, in the Far East.
    In each center, we will be able to operate 3 patients per day. Of course this capacity will need to be expanded further later-on.

    5.4-Can you tell us in which country and which hospital ?
    This information will be given in due time.

    5.5-How long is the waiting list [as of application and input receipt date [MRI/CT SCAN and EMG]]?
    About 3/4 months.

    5.6-What about the USA ?
    Legislation [eg, w.r.t liability] makes it a bit complex to envisage a center over there in the very short term.

    5.7-What about France ?
    The legal situation is complex and it seems that even stem-cell extraction might potentially be an issue. It is very difficult to have a clear picture of what is allowed and what is not. The reasons are most probably linked to ethical fears, which are absolutely not relevant with our procedure since the patient receives his own cells. The bottlenecks can most probably be removed when results prove that those barriers are preventing progress. At that moment the SCI patients community could help through raising public awareness. Strong evidence should be built up at first.


    6.1-How could the SCI community help remove the bottlenecks, so that the procedures can go on and be applied to the highest possible number of patients ?
    Once we have a sufficient number of data and cases proving effectiveness of the procedure, the bottlenecks to be able to start the procedure in a given country can most probably be removed when results prove that the existing barriers are preventing progress. At that moment the SCI patients community could help through raising public awareness. Strong evidence should be built up at first.

    Also, once the first stage passed, the capacity issue should be tackled. Neurosurgeons will need to be trained. The SCI patient community could create a network, spread the word to other patients and relay the message to the medical community in order to activate the identification of centers and neurosurgeons to carry out the procedure.

    6.2-Would you welcome a co-ordination of communication from and to SCI patients globally ? Do you think that I could play this role in the future [if the SCI community, eg carecure and Alarme] agrees to give me that 'mandate' ?
    I would definitely welcome that proposal and would strongly appreciate your support in co-ordinating feedback from & to the SCI community.

    6.3-What about media communication ?
    Communication will firstly be focused on the patient community. Meeting will Richwelsh63 [carecure] will take place in end July. Media [BBC, CNN, Nova..] will film some patients and follow their progress. Nova [Dutch TV] will film the surgery in end July. But broadcasting will be carried out later [most probably September, to be confirmed].

    6.4-Why have successful patients not communicated so far ? why so little media involvement ?
    The successful patients have communicated in Turkey. There, media was highly involved too. There was no broader communication due to language problem. None of the SCI patients operated so far do speak English.

    6.5-Since patients who underwent surgery so far cannot speak English, would you please provide a video showing the functional progress of the patients ?
    Yes , video of patient 1 is going to be sent to you. Video of patient 3 will follow later. Video of patient 2 : authorization has not been given yet by patient himself.

    6.6-Do you plan to make any official, scientifically recognized , medical publication ? If so, in which journal ? When do you plan the publication to take place ?
    Yes, a publication is in progress. Target journal is Lancet. No target date can be given. Once more, our first priority is to get results.
    Last edited by Wise Young; 07-28-2005 at 12:03 AM.

  6. #406

    Wink Very interesting..

    6.6-Do you plan to make any official, scientifically recognized , medical publication ? If so, in which journal ? When do you plan the publication to take place ?
    Yes, a publication is in progress. Target journal is Lancet. No target date can be given. Once more, our first priority is to get results.
    __________________________________________________ ___________

    The publication should be released in September of 2005, this is what i have been informed, i too am looking into it further as it sounds to be very promising. However, the cost is close to 16K for this procedure if i am correct.

  7. #407
    Susan, thanks. I changed it from €15,000 to €16,000. Wise.

  8. #408
    Member mka's Avatar
    Join Date
    Aug 2003
    Again Hi All,
    All of you are very welcome to our city Ankara - Turkiye (Capital City). I wish I could help all of you.
    We are waiting for the progress same as you. If I hear something do not worry I will share this with you.
    See you all soon...

  9. #409
    Senior Member
    Join Date
    Mar 2004
    Warner Robins, GA, US
    Dr. Young,

    You mentioned ,among possible risks, an ascent of lesion. How could that happen?

    You also wrote that an ascent of lesion was possible for people with thoracic injury, do you mean that a paraplegic could become quadraplegic as a result of a medical procedure, or simply of long-term changes?
    Last edited by gretchen; 07-28-2005 at 09:16 AM.
    gretchen 1

  10. #410
    Quote Originally Posted by gretchen
    Dr. Young,

    You mentioned ,among possible risks, an ascent of lesion. How could that happen?

    You also wrote that an ascent of lesion was possible for people with thoracic injury, do you mean that a paraplegic could become quadraplegic as a result of a medical procedure, or simply of long-term changes?

    Any time that one does surgery on the spinal cord, there is the possibility that there will be damage to the spinal cord. There may be hemorrhage, infection, expansion of the cells into a tumor, or worse possibilities that may occur with transplantation of cells into the spinal cord. There may be inflammation, as a result of the transplant or surgery. All these can result in an ascent of the lesion. Of course, if it ascends far enough, a paraplegic could become quadriplegic.


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