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Thread: INVIVO Articles

  1. #51
    Senior Member lunasicc42's Avatar
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    Quote Originally Posted by Nowhere Man View Post
    What if a scaffold + neural stem cells doesn't significantly improve function in chronic SCI (almost a certainty in my mind)? Are there animal studies that show it may?

    It's still great that if it really works, far less people would have to live with severe SCI. It's a hell I wouldn't wish on anybody.
    I was under the impression that invivo stated that they have the largest population of chronicly injured monkeys in the world?
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  2. #52
    Quote Originally Posted by Nowhere Man View Post
    What if a scaffold + neural stem cells doesn't significantly improve function in chronic SCI (almost a certainty in my mind)? Are there animal studies that show it may?

    It's still great that if it really works, far less people would have to live with severe SCI. It's a hell I wouldn't wish on anybody.
    A chronic condition can be made acute, wouldn't you agree?

  3. #53
    Quote Originally Posted by Dlevy View Post
    A chronic condition can be made acute, wouldn't you agree?
    Care to explain why you think that?

  4. #54
    Quote Originally Posted by lunasicc42 View Post
    I was under the impression that invivo stated that they have the largest population of chronicly injured monkeys in the world?
    a) People & companies lie, I'm not saying they are but you have to take it with a grain of salt.

    b) Didn't Frank Reynolds say that like 4 years ago? Yet are there any research results? Seems like if they were having success..ANY success...we would have heard something.

    c) Just because they are testing it on chronic monkeys does not mean it will work. I could be testing blue m&m's on the largest population of chronic dogs but that should not give you hope of an imminent cure.

  5. #55
    Quote Originally Posted by lunasicc42 View Post
    Nowhereman, I am a big miami project supporter, I always hope that they are just being quiet on the technical side but are steadily moving along ...I sort of imagine them swooping in and saving the day, what are your thoughts on them? I used to know a doctor down there and he said that most of their pre-clinical stuff was actually done on mini-pigs?
    I am not a supporter of the Miami Project. I'm not against them either. I have never given them any money. I don't know too much about them and that is their fault. They are too quiet, as you say. I think they focus mostly on acute injury, not chronic. I can't think of any of contributions to chronic SCI research that they have made since I've been injured in 09.

    I can't assume they are working on chronic SCI behind the scenes quietly. I have to assume they are not! If they want donations, they need to communicate to SCI community directly, and often, specifically describing their current status in labs and near future projects. Maybe they are but I haven't seen/heard it. Their website is vague.

    They make a lot of money but have very little to show for it in terms of chronic Sci. I understand that much of their government funding is probably restricted to acute SCI. But if I were Marc Buoniconti, a chronic SCI himself, I would revamp my strategy.


    We can't just assume an organization is just going to swoop in and save the day. We need updates and accountability.

  6. #56
    Quote Originally Posted by JamesMcM View Post
    What did you think of the French Dr's work? Dr.Courtine I believe with the Epidural implant that causes very little information or tissue damage , The device also uses Neuroprosthetics in conjunction with epidural stimulation. I'm almost certain they use those drugs, because that video was the first time I heard about them. Epidural stimulation has shown not incredible by any means but modest recovery in humans, sexual function is big for all of us. So I think this implant in humans will be very interesting.

    I agree about Dr. Murray Blackmore but his work is so young, we should obviously be donating towards the research. But there's just not much to show for it yet.
    Dr. Blackmore has been at if for just a few years. Patience. There is huge potential in genetics so testing genes must get done. It may take a long time but the sooner it starts, the sooner it will get done. I think right now, potential for efficacy is more important than how soon it can be FDA approved.

  7. #57
    Quote Originally Posted by Nowhere Man View Post
    Care to explain why you think that?
    Wouldn't it be possible to cut out the damaged portion leaving a new acute injury?

  8. #58

    InVivo’s Neuro-Spinal Scaffold used for 2nd spinal cord injury patient

    Published: January 22, 2015 | Source: beckersspine.com

    InVivo Therapeutics enrolled the second patient in their Neuro-Spinal Scaffold to treat traumatic spinal cord injury.
    The patient is enrolled at Carolinas Medical Center, part of the Carolinas HealthCare System in the study to evaluate the safety and feasibility of the Neuro-Spinal Scaffold.
    Here are five things to know about the procedure:
    1. Domagoj Coric, MD, chief of neurosurgery at Carolinas Medical Center, performed the procedure with John Ziewacz, MD. Both surgeons are part of the Carolina Neurosurgery and Spine Associates and Dr. Coric is a co-principal investigator at the site.
    2. This is this second-ever spinal surgery performed using the Neuro-Spinal Scaffold to treat acute spinal cord injury. The patient sustained a severe multi-trauma injury requiring two days for medical stabilization before proceeding with the spine surgery and implantation.
    3. The procedure took place as part of an investigational device exemption pilot study intended to capture preliminary data in five patients who have thoracic spinal cord injury. The company expects to conduct a pivotal study for FDA clearance following this trial.
    4. Dr. Coric deemed the implantation procedure successful. This surgery came soon after InVivo Therapeutics re-opened their trial. The FDA only requires 30 days of safety day for this second surgery instead of the original 90 days before reopening enrollment.
    5. If there aren’t significant safety issues, the company anticipates reopening the study for concurrent enrollment of three subjects in about two months.
    Written by Laura Dyrda
    InVivo Therapeutics Announces Enrollment of Second Subject in Pilot Spinal Cord Injury Trial
    - See more at: http://www.spinalcordinjuryzone.com/....ykTiFBw5.dpuf
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  9. #59
    Quote Originally Posted by Dlevy View Post
    Wouldn't it be possible to cut out the damaged portion leaving a new acute injury?
    Ok. I'm going to tell you, but please try to remember it in the future. I've repeated this many times. I see you are new so I understand your confusion. When a person has an acute spinal cord injury, their original, beautiful work-of-nature spinal cord is still present. But over the course of a few weeks, their spinal cord literally dies. The tracts that go from the brain to the muscles (simplified) get cut off at the injury site. Above the injury site the axons are still there, but below they die and get disposed of by your body. Sensory tracts that go from muscles to the brain, get cut off at injury site. Below the injury site they are still there, but above the injury site they die and get disposed of. So motor tracts will need to regenerate from the injury site all the way down the entire cord, making exits at the right place. As you know different levels of spinal cord control different muscles. This could be a meter or so in length. The sensory tract needs to regenerate from injury site all the way up to the brain. Could be a meter or more in length. Not only would they need to grow these long distances but they would need to reconnect with their targets or close to. Ex: your foot sensory axon needs to grow to the precise spot in your brain that feels your foot, or at least close.

    OR, for acute SCI, they can keep the spinal cord from dying! They can preserve the spinal cord, keeping the beautiful and complex circuitry in place. That's what the Invivo scaffold does. It preserves. It does NOT rebuild.

    So NO, you cannot re-cut a chronic SCI to make it acute again. Our circuitry is already dead and disconnected by many inches - meter in length.

    However, if a treatment causes axon regeneration (none yet do in a significant amount), then recutting the spinal cord MAY help. May not. No one knows because it hasn't been done that I know of. For a cervical injury it might not be worth the lost function (from recutting) to get what shitty regeneration a treatment may offer.

    A regenerative treatment will never come close to the original spinal cord that only an acute SCI protective treatment can save.

    Make sense?

    I really wish Dr. Wise would add this question, and answer himself, to the 10 most frequently asked questions thread.

  10. #60
    Senior Member Tbone57's Avatar
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    very good but....NEVER say NEVER

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