"Expression profile of EphA receptors after spinal cord injury in adult rats."

Lillian Cruz-Orengo1, Johnny Davis Figueroa1, Ixane Velбzquez1, Margarita Irizarry-Ramнrez1, Christopher A Willson2, Hope Jones2, Scott R Whittemore2, Jorge David Miranda1. 1Physiology, UPR School of Medicine, San Juan, Puerto Rico, 2Neurological Surgery, University of Louisville School of Medicine, Kentucky Spinal Cord Injury Research Center Neurological Surgery. Physiology 924.3. Featured topic session #895: "Long-term plasticity and SCI."

Researchers are looking at molecular activities that occur early in development that "come back" after trauma, such as a spinal cord lesion. They observed such genetic "reexpression" in spinal cord injury. Knowing the expression profile of EphA3, A4 and A7 receptors, they are looking at their specific contribution toward regeneration. When they "shut down" the three receptors effect at the same time they observed a better locomotor activity at the acute phase of animal recovery.

Funding: NIH (SNRP, others), State of Kentucky (KSCHIRT), Norton Health Care, American Psychological Association