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Thread: Stem Cells Of Limited Use For Cardiac Muscle Repair(adult cells!)

  1. #1
    Senior Member Max's Avatar
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    Stem Cells Of Limited Use For Cardiac Muscle Repair(adult cells!)

    Stem Cells Of Limited Use For Cardiac Muscle Repair
    New evidence suggests that a promising investigational treatment for patients with damaged hearts -- using adult stem cells to regenerate heart tissue -- may not work as planned. In the December 2004 issue of the Journal of Clinical Investigation, researchers from the University of Chicago show that although stem cells derived from bone marrow can find their way to areas of damaged heart muscle, infiltrate into these regions and proliferate, they do not mature into new cardiac muscle cells

    http://www.sciencedaily.com/releases...1206210424.htm



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  2. #2
    Thanks Max. The study was done using a subset of bone marrow stem cells and then later repeated with "whole bone marrow" [I would assume all of the stem cell subtypes in BM].

    The experiment was done by transplanting the stem cells into mice that lacked a certain gene and the results show that stem cells [from a strain of mice that normally expresses the gene] that integrated into the gene-defficient mice did not start to express that gene. The study adds more weight to the belief that stem cells take their cues on what to do from the local environment.

    The study also demonstrates that stem cells fuse with existing cells and differentiate when being recruited to help out. An unanswered question remains: Is cell fusion an intermediate step to proper differentiation [or vice-versa] of the transplanted cells?

    -Steven
    ...people believe what they want to believe when it makes no sense at all

  3. #3
    http://www.betterhumans.com/News/new...D=2004-12-16-1

    Blood Stem Cell Heart Repair Clarified

    Findings could help resolve debate over clinical use

    Betterhumans Staff

    12/16/2004 3:41 PM



    Regenerating damaged hearts with blood stem cells is clinically promising, say researchers who have learned more about how the stem cells become two kinds of cells needed to restore heart function.

    The researchers, from the University of Texas and the Texas Heart Institute, have shown how the stem cells use different ways to become two distinct types of cells needed in the heart-cardiac muscle cells that contract and endothelial cells that line blood vessels throughout the organ.

    Experimenting with humans stem cells in mice, the researchers found that the stem cells primarily "fuse" onto mouse cardiac cells to produce new muscle cells that have both human and mouse DNA. But to form new blood vessel cells, they found that the cells "differentiate" or mature by themselves, presumably to patch damaged mouse blood vessels. Two months after mice with ailing hearts were treated with human stem cells, about 2% of cells in their heart had evidence of a human genetic marker.

    According to study lead author Edward Yeh of the University of Texas's M. D. Anderson Cancer Center, the findings should help resolve debate as to whether stem cell transfer actually creates new types of cells that last within the heart.

    "We have shown that these stem cells create both types of tissue needed to repair areas of damage, that they use two different ways to develop them, and that these cells can persist for up to a year, which is a long time in the life of a mouse," says Yeh. "Most of all, this study is important because it begins to explain why stem cells can help a heart heal."

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