An Embryonic Stem Cell Model For Parkinson's Disease
Despite the well-characterized cellular basis of Parkinson's disease -- the degeneration of dopamine-production neurons -- the molecular mechanisms responsible for the neurodegeneration remain unknown. Part of the challenge is finding a model that can adequately mimic the loss of dopamine cells. In two papers published in PLoS Biology, Asa Abeliovich and colleagues make the case that a model based on mouse embryonic stem cells offers a promising platform for dissecting the disease mechanism of Parkinson's.