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Thread: Umbilical Cord Blood-Derived Stem Cells Given Intravenously Reduce Stroke Damage

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    Senior Member Max's Avatar
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    Umbilical Cord Blood-Derived Stem Cells Given Intravenously Reduce Stroke Damage

    Umbilical Cord Blood-Derived Stem Cells Given Intravenously Reduce Stroke Damage
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    STROKE HUMAN UMBILICAL CORD BLOOD STEM CELLS MANNITOL CELL THERAPY
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    Stem cells taken from umbilical cord blood,then given intravenously with a drug known to temporarily breach the brain's protective barrier, dramatically reduced stroke size and damage in an animal model.



    Editor's note: Photos of Dr. Borlongan and Dr. Sanberg are available upon request

    Newswise - Stem cells taken from umbilical cord blood, then given intravenously along with a drug known to temporarily breach the brain's protective barrier, can dramatically reduce stroke size and damage, Medical College of Georgia and University of South Florida researchers say.

    "What we found was interesting, phenomenal really," says Dr. Cesario V. Borlongan, neuroscientist and lead author of the study published in the October issue of the American Heart Association journal, Stroke.

    http://www.newswise.com/articles/view/507261/

    "Researchers first gave the drug, mannitol, to provide temporary passage through the blood-brain barrier then transfused human umbilical cord blood cells into a stroke animal model. When used in the first hours and days following a stroke, stroke size decreased by 40 percent and resulting disability was significantly reduced.

    "We have two potential routes of delivery, intravenously through the jugular vein or directly transplanting the cells into the brain," says Dr. Borlongan. Initial studies comparing the two approaches showed the intravenous approach ineffective until researchers added mannitol.

    "Intravenous delivery of (human umbilical cord blood cells) poses an efficient and non-invasive cell therapy for (central nervous system) disorders characterized by a narrow therapeutic window," the researchers write. "A multi-drug treatment for stroke may be realized via a cell-based therapy that involves routine clinical IV infusion of stem/progenitor cells allowing the biological release of a cocktail of trophic factors into the brain."

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    Senior Member Max's Avatar
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    Wise,

    Could this method work in acute sci?

  3. #3
    Max, it is an intriguing idea. Thanks for posting. We tried putting umbilical cord blood stem cells intravenously and did not find many that went into the spinal cord. Wise.

  4. #4
    Senior Member Max's Avatar
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    Originally posted by Wise Young:

    Max, it is an intriguing idea. Thanks for posting. Wise.
    It might work with drug breaking blood/brain barrier

    Don't forget me when you'll get Nobel prize
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