According to these research papers from Pubmed:

ppar alpha agonist can rapidly reduce chronic pain
and ppar gamma agonists also help with pain.

The research I guess uses experimental drugs.

It occurred to me that, if we can find safe natural compounds that have ppar alpha agonist actions and ppar gamma agonist actions, we might have a pain control nutrient on our hands.

Bodybuilders use sesamin oil if I'm not wrong and I think its a ppar alpha agonist. Could it work?
Does ppar alpha have subtypes?

Is there a natural ppar gamma agonist out there.
Anyone care to join in the discussion?