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Thread: dra Cueto in Spain

  1. #1

    dra Cueto in Spain

    dear Dr YOUNG i`m new in this forum and my question is what do you think about Dra Cueto procedure research.

    I´m from Spain i´m 22 and c6 injured in 24/11/2002 and i always believed in a cure.

    Excuse my poor english.

  2. #2
    Isildur, I admire Dr. Almudena Ramon-Cueto a great deal. She is working very hard right now on getting proof of safety and efficacy of OEG cells in monkeys. I hope that this will be sufficient to initiate a clinical trial in Spain. Wise.

  3. #3
    thanks dr. young you are a great person.
    where can i get more information about Dra. Cueto procedure?

  4. #4
    if you do a search for oeg (olfactory ensheathing glia) or cueto, you will find hundreds of topics on this site. Note that oeg cells are already being transplanted into people in various places around the world. See articles about Dr. Huang's operations in Beijing. Wise.

  5. #5
    Senior Member KIM's Avatar
    Join Date
    Jul 2001
    Piedralaves (Avila) SPAIN
    The latest of the Dra. Almudena Ramon Cueto

    The transplant of olfatoriy glia receives strength to medular injury . Seven groups of investigation have confirmed in mice the viability of the transplant of olfatory glÃ*a as therapeutic option in the treatment of the injuries of the spinal marrow. The pioneer in these findings, Almudena Ramon, of the Institute of Biomedicina of Valencia, has pointed the methodology necessary to begin the tests in primates and to confirm or not it effectiveness of the strategy, before being applied to humans.
    The surrounding transplant of olfatory glÃ*a seems to be outlined as future option in the treatment of the traumatic injuries of the spinal marrow, when obtaining axonal regeneration and the functional recovery in murine experiments. At the moment, seven groups of investigation in the world have confirmed the results obtained by the Unit of Neural Regeneration of the Institute of Biomedicina, in Valencia, that directs to Almudena Ramon.
    A test published in the Nature magazine compared the results obtained by the diverse groups that are working in different therapeutic routes to approach the injury to medular, putting of relief the interest waked up by the works that study the surrounding transplant of olfatory glÃ*a . After the successes obtained in rodents, the Group of Regeneration in the Nervous System of Primates, of the Institute of Biomedicina of Valencia, of the CSIC, that also directs to Almudena Ramon, has dedicated last years both to complete the technology with the objective to initiate the investigation with primates now, designing in addition a compatible methodology with the human clinic.
    The investigation with monkeys is an essential step before initiating the tests in humans, since it is not possible to give the jump of rodents to people by the fundamental differences in the nervous system of both species. The Unit of Neural Regeneration of the Institute of Biomedicina of Valencia is located thus in a sharpshooting position, "since no other laboratory of the world at the moment has a methodology to make studies on this type of therapy of injury medular in primates nonhuman", has explained Almudena Ramon. From now on the tests on regeneration of the spinal marrow in primates, project will begin that counts on the financial collaboration of the Council of Health of the Meeting of Castile and Leon.
    The test of Nature emphasized the hopes waked up by this type of therapeutic strategy, to the salary validated already seven groups the repairing technique used by the Unit of Neural Regeneration of the Institute of Biomedicina, whereas the routes followed by other groups, according to explain Ramon, "have not obtained a so intense endorsement to their results". Between these other strategies the mielin inhibitor administration includes itself, molecule that prevents the regeneration of axones, thus studies the administration of antibodies to block the action of the mielin, study developed in rodents knock-out in which it is tried to see if axonal regeneration by this route is possible. Another line is the transplant of activated macrophages to fagocitate the mielin, yet the results are not conclusive.
    Late advances the data obtained by the group of Ramon not yet have been published. However, the specialist has advanced to DM that the study of the characteristics of glÃ*a surrounding olfatoria of rodents and primates to value the existence of similar properties in the capacity of regeneration of the nervous system has offered "positive surprises". The laboratory of Almudena Ramon is also working in the genetic modification by means of the introduction of telomerase to obtain a greater number of cells. Thus one has been able to extend to the average life of the cells introducing telomerasa, "as it forms nononcogénica to prolong the average life of the cells, avoiding the risk of formation of tumors". This work is developed in collaboration with Maria Blasco, of the CNIO, and has given rise to a patent.
    Future challenges Once obtained glÃ*a surrounding olfatoria modified genetically to express telomerase, the objective of the work was to analyze if it conserves the suitable properties so that it is possible to be used in transplants. Thus it would be possible to be improved the repairing effectiveness of glÃ*a and to be had in the future more powerful a therapeutic instrument. The group of Almudena Ramon, of the Institute of Biomedicina of Valencia, has been first in proposing to glÃ*a surrounding olfatoria like candidate to be transplanted to promote axonal regeneration, obtaining the greater functional and histológic recovery in mammals with complete injury of his spinal marrow. to later confirm these results in primates and in humans, surrounding the autólogus transplant of glÃ*a from cells of the olfatory bulb of the own individual would by ricochet avoid the risk and the difficulty to find a donor suitable. Every year they take place in Spain near thousand injuries medulares. The 60 percent is caused by traffic accidents. The young population, until the 35 years, is affected by this type of injury, that gives rise to paraplejia and tetraplejia.

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