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Thread: BONE MARROW CELLS ENHANCE REGENERATION OF INJURED SPINAL CORD IN RATS BY MEANS OF GRAFTING VIA CSF.

  1. #1

    BONE MARROW CELLS ENHANCE REGENERATION OF INJURED SPINAL CORD IN RATS BY MEANS OF GRAFTING VIA CSF.

    Going to present Nov. 12th per Scholar One. GREAT STUFF!!!!!

    Abstract View
    BONE MARROW STROMAL CELLS ENHANCE REGENERATION OF
    INJURED SPINAL CORD IN RATS BY MEANS OF GRAFTING VIA CSF.
    Y.Suzuki1*; M.Ohta1; H.Chou1; N.Ishikawa1; K.Kataoka1; K.Suzuki1; S.Suzuki1;
    M.Dezawa2; C.Ide2
    1. Plastic and Reconstructive Surg, Kyoto Univ. Grad. Sch. of Med, Kyoto, Japan
    2. Anat. and Neurobiology, Kyoto Univ Grad Sch of Med, Kyoto, Japan

    Bone marrow stromal cells (MSCs) are reported to enhance regeneration of central nervous system and promote functional recovery. In this study, cultured MSCs were transplanted into cerebrospinal fluid (CSF) and we examined whether the transplanted cells could reach the injured position and promote the regeneration of nervous tissue or not. Using Wistar rats, a standard spinal cord contusion injury at the midthoracic level (T8-T9) was made using the New York University weight-drop device. The cultured MSCs labeled with GFP were injected into 4th ventricle. Behavioral evaluation was performed using the open-field BBB scoring system every day after operation. Treated rats showed better performance of gaitthan control rats without transplantation of MSCs. One, two, three, and four weeks after operation, rats were sacrificed for histological evaluation. A few days after transplantation, many MSCs were seen in the injured position. Five weeks after transplantation, the cavity volume at the lesion of the MSC's-grafted rats was significantly smaller than that of control rats. These results suggest that MSCs might be able to promote regeneration of the injured
    spinal cord by means of grafting through CSF.

    Citation:
    Y. Suzuki, M. Ohta, H. Chou, N. Ishikawa, K. Kataoka, K. Suzuki, S. Suzuki, M.
    Dezawa, C. Ide. BONE MARROW STROMAL CELLS ENHANCE REGENERATIONOF INJURED SPINAL CORD IN RATS BY MEANS OF GRAFTING VIA CSF.
    Program No. 790.3. 2003 Abstract Viewer/Itinerary Planner. Washington, DC: Society
    for Neuroscience, 2003. Online.

  2. #2
    Dr. Young,

    How does this correlate with the findings of the other group partially funded by Neuronyx? It seems that these guys are finding migration of the MSC's.

    Any and all thoughts are appreciated.

    BTW: Thanks for going to the presentation. You are truly one of the good guys.

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