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Thread: Amitrypiline safety

  1. #1

    Amitrypiline safety

    I am considering giving this a try for my undiagnosed pain/AD issue. However, in reading about it, and other tricyclics, there seems to be a lot of warnings about elderly people using it. Some even suggest it should not be prescribed for people 60 or older. Given that I am 74, obviously I am concerned. Any seniors out there have experience with it?
    You will find a guide to preserving shoulder function @
    http://www.rstce.pitt.edu/RSTCE_Reso...imb_Injury.pdf

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  2. #2
    The cautions are primarily for the anticholenergic side effects of these drugs, which can result in confusion in some (not just elders) and increase the risks for urinary retention. The latter can be a real problem for men with BPH, but is a reason that these drugs are often used to supplement drugs like Ditropan or Detrol in those with SCI/D.

    (KLD)

  3. #3
    Thanks KLD. Since I have an ileal conduit, retention will not be a problem. I am a bit confused about your statement that they are used as a supplement to ditropan and detrol. Why is it used to supplement them?
    You will find a guide to preserving shoulder function @
    http://www.rstce.pitt.edu/RSTCE_Reso...imb_Injury.pdf

    See my personal webpage @
    http://cccforum55.freehostia.com/

  4. #4
    Off topic, but my time on Amitryptiline did not result in confusion, but it did result in dry mouth. This sounds benign but it will take a toll on your teeth unless you are very careful to avoid sweets, brush regularly, and possibly to use something to keep your mouth moist, such as the commonly used biotene.

  5. #5
    Scifor55 - the dosing for neuropathic pain is very low for amitriptyline - 25 mg . People who used this as an early antidepressant med were taking over 100 mg. Increasing the dose beyond 50 mg doesn't appear to make a difference when used for NP pain. Elavil even comes in 12.5 mg pills. So you could try a little dose and try it for a month or 2. You can always stop it if the S/E are bad or it has little effect.

    I am 55 and took 25 mg for pain for 9 years. I had to stop it due to my prehypertension. Otherwise it worked well and has the added benefit , if taken at night, to help with sleep.

  6. #6
    Thanks Arndog. I had hoped that might be the case. I have an appointment with my doc in a few days and am going to discus it. There are a few other meds that have been suggested but this one came out on the top of my list. In the state I am in, it would not hurt if I got a bit of the antidepressant effect too.
    You will find a guide to preserving shoulder function @
    http://www.rstce.pitt.edu/RSTCE_Reso...imb_Injury.pdf

    See my personal webpage @
    http://cccforum55.freehostia.com/

  7. #7
    Hi SCIfor55, I tried it at night for nerve pain. It was a very low dose like 12.5 mg. While it helped me fall right to sleep I was groggy and tired the next morning. Dry mouth and increased appetite was noticed. I could have got past all that and maybe side effects would diminish in time but didn't get the chance to try it long term. You need to know it does decrease blood pressure. The next day my blood pressure was terrible even after taking midodrine. Watch for that!
    Aerodynamically, the bumble bee shouldn't be able to fly, but the bumble bee doesn't know that, so it goes on flying anyways--Mary Kay Ash

  8. #8
    Quote Originally Posted by SCIfor55yrs. View Post
    Thanks KLD. Since I have an ileal conduit, retention will not be a problem. I am a bit confused about your statement that they are used as a supplement to ditropan and detrol. Why is it used to supplement them?
    Because of its fairly strong anticholenergic side effects. Thus (in addition) the risks for constipation and dry mouth, but this is often dose related. When used for pain management, as above, a lower dose is used than for its primary use as an antidepressant. It is not a very good antidepressant, actually.

    (KLD)

  9. #9
    Hi,
    I take 25 mg at night for nerve pain. It helps with sleep and the only side effects I have had are dry mouth, it makes my urinary retention much worse and makes my tinnitus louder (only temporarily though).

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