Quote Originally Posted by tomsonite View Post
How could drugs activate spinal CPGs? Is it that the drugs simply allow the CPG to be more easily excited? Or do they expect people to take a drug and suddenly see a locomotor like response in the legs?
tomsonsite, the central pattern generator CPG has receptors to neurotransmitters. Scientists have long known (like 50+ years) that it is possible to stimulate the CPG by injecting serotonin and other excitatory neurotransmitters intrathecally (into the cerebrospinal fluid surrounding the spinal cord). It has been a while since I looked at this trial but I assume that the spinalon combination is being injected intrathecally into patients with a pump (much like baclofen is injected but for shorter periods and under manual control, so that the person can apply the drug when walking is needed). One can of course stimulate the CPG electrically as well. Wise.