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Thread: UC Irvine - hav we all seen this one?

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  1. #1

    UC Irvine - hav we all seen this one?

    Last edited by Christopher Paddon; 11-17-2011 at 11:23 PM.

  2. #2

    Comments from Dr Young, Dr Silver?

    The article seems to be more than a year old, yet it appears on the November 17 issue. Has anyone heard any more recent news about it?

  3. #3
    Quote Originally Posted by mamadavid View Post
    The article seems to be more than a year old, yet it appears on the November 17 issue. Has anyone heard any more recent news about it?
    Dr. He is the senior author on a paper published by my former graduate student Kai Liu, who showed that knocking out PTEN in mice strongly stimulates corticospinal tract regeneration. This study showed that the importance of genetic control of growth. CNS axons of course once grew during development but genetic stimulation of such growth turns off during development. It seems that PTEN is part of the mechanisms that stops axonal growth, acting through downstream mechanisms such as mTOR.

    This is the first time that I have heard STAT3 being proposed to be a major factor. We recently published a paper in PLOS ONE, showing the lithium inhibits astrogliogenesis by inhibiting STAT3. Of course, lithium stimulates regeneration of spinal tracts probably by stimulating NFAT and WNT/beta-catenin. There are some suggestions that lithium also acts by up regulating mTOR but all these still need to be studied. The reason why we are using lithium is because it facilitates regeneration and neurotrophin production by stem cells.

    Dr. He is moving from Harvard to UC Berkeley. He will be doing so in January. It is s significant loss to Harvard and a great addition to Berkeley.

    Wise.

  4. #4
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    Last week Zhigang He had an article published in Nature online, showing that blocking both SOCS3 and pTEN led to a ten fold regeneration in the optic nerve compared to pTEN inhibition alone.

    http://www.nature.com/nature/journal...ture10594.html

  5. #5
    This is the evolution, even more exciting IMO
    Sustained axon regeneration induced by co-deletion of PTEN and SOCS3

    .....Here we show that, remarkably, simultaneous deletion of both PTEN and SOCS3 enables robust and sustained axon regeneration. We further show that PTEN and SOCS3 regulate two independent pathways that act synergistically to promote enhanced axon regeneration...

    http://www.nature.com/nature/journal...ture10594.html
    Last edited by paolocipolla; 11-18-2011 at 07:59 AM.
    In God we trust; all others bring data. - Edwards Deming

  6. #6
    Here goes , the only trial for chronic spinal cord injury is the one that Dr. wise is doing , and if that fails then forget about a cure for at least ten years and here I am being optimistic.

  7. #7
    Quote Originally Posted by lakboy View Post
    Here goes , the only trial for chronic spinal cord injury is the one that Dr. wise is doing , and if that fails then forget about a cure for at least ten years and here I am being optimistic.
    Check out the chart for spinal cord injury clinical trials here...China is not the only one with a trial.

  8. #8
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    PTEN activity is low early during development, allowing cell proliferation. PTEN then turns on when growth is completed, inhibiting mTOR and precluding any ability to regenerate.
    Would that mean that an infant who suffers a spinal cord injury is less likely to become paralyzed????
    KB

  9. #9
    For my thoughts on why pten is a poor target for SCI therapy any time soon- http://sci.rutgers.edu/forum/showthr...=148545&page=2

    As a side note, Dr He's lab that did this is in the middle of moving to UCSD from Harvard so they can take advantage of the better research environment for stem cells in California.
    Last edited by dr.zapp; 11-19-2011 at 01:33 AM.

  10. #10
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    Don't get all excited about this, as I said in my earlier post- PTEN is a tumor suppressor! You take it away and you get cancer.
    So same thought different question, why aren't infants more susceptible to cancer?
    KB

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