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Thread: Highly Superporous Scaffolds for SCI

  1. #1

    Arrow Highly Superporous Scaffolds for SCI

    J Biomed Mater Res A. 2011 Dec 15;99(4):618-29. doi: 10.1002/jbm.a.33221. Epub 2011 Sep 27.
    Highly superporous cholesterol-modified poly(2-hydroxyethyl methacrylate) scaffolds for spinal cord injury repair.

    Kubinová S, Horák D, Hejčl A, Plichta Z, Kotek J, Syková E.
    Source

    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, V*den̆ská 1083, 14220 Prague 4, Czech Republic. sarka.k@biomed.cas.cz.

    Abstract

    Modifications of poly(2-hydroxyethyl methacrylate) (PHEMA) with cholesterol and the introduction of large pores have been developed to create highly superporous hydrogels that promote cell-surface interactions and that can serve as a permissive scaffold for spinal cord injury (SCI) treatment. Highly superporous cholesterol-modified PHEMA scaffolds have been prepared by the bulk radical copolymerization of 2-hydroxyethyl methacrylate (HEMA), cholesterol methacrylate (CHLMA), and ethylene dimethacrylate (EDMA) cross-linking agent in the presence of ammonium oxalate crystals to establish interconnected pores in the scaffold. Moreover, 2-[(methoxycarbonyl)methoxy]ethyl methacrylate (MCMEMA) was incorporated in the polymerization recipe and hydrolyzed, thus introducing carboxyl groups in the hydrogel to control its swelling and softness. The hydrogels supported the in vitro adhesion and proliferation of rat mesenchymal stem cells. In an in vivo study of acute rat SCI, hydrogels were implanted to bridge a hemisection cavity. Histological evaluation was done 4 weeks after implantation and revealed the good incorporation of the implanted hydrogels into the surrounding tissue, the progressive infiltration of connective tissue and the ingrowth of neurofilaments, Schwann cells, and blood vessels into the hydrogel pores. The results show that highly superporous cholesterol-modified PHEMA hydrogels have bioadhesive properties and are able to bridge a spinal cord lesion. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2011.
    http://www.ncbi.nlm.nih.gov/pubmed/21953978

  2. #2
    - on it's way to a trial? - It looks really good..
    "It's not the despair, I can handle the despair! It's the hope!" - John Cleese

    Don't ask what clinical trials can do for you, ask what you can do for clinical trials. (Ox)
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  3. #3
    We had talked before in a thread that Eva Sykova had been working with Neurogel, but had started working with her own scaffolding.

  4. #4
    Yes I remember her working with Neurogel - wonder what they are doing now, and why she has decided to move on, on her own, if that is the case?..
    "It's not the despair, I can handle the despair! It's the hope!" - John Cleese

    Don't ask what clinical trials can do for you, ask what you can do for clinical trials. (Ox)
    Please join me and donate a dollar a day at http://justadollarplease.org and copy and paste this message to the bottom of your signature.

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