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Thread: Live from Working 2 Walk 2011!

  1. #91
    Senior Member KIM's Avatar
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    Do we know what injuries Chondroitinase can work on lets say elongated or on totally severed can it work on both scenarios?

  2. #92
    Not on totally severed. We need to bridge the lesion and get axons out the other side and to their targets for some measure of supraspinal control. This strategy has worked remarkable well when applied at acute stages for the respiratory (See Alilain et al Nature) locomotor (See Houle et al J Neuroscience ) and now urinary (Lee et al in preparation and see W2W 2011 video) systems. We still have a way to go for bridge building in chronic cord injury although there was one paper from the Houle lab showing some promise in a chronic model (not as robust as acute). Ch'ase has been shown to improve function via sprouting/plasticity consistently in models with incomplete lesions and especially where rehab is instituted.

  3. #93
    Quote Originally Posted by kate View Post
    Emphasis mine.

    The community should, imo, pay attention to this.
    What can we do, write to the company. Can Dr Silver give us some suggestions

  4. #94
    Dear Dr. Silver ,

    Hi , a question , how do you do the graft on CONTUSION chronic sci (assuming the cord is not broken and is narrowed due to the age of injury and athrophy ,etc ) ? do you actually make a cut in the cord intentionaly and then make a graft inside or do you make the graft from the side , etc , how does it work ? (sorry if i am ignorant about this and you explained this somewhere else before) . also , for now, and for the first time clnical trial with this , do you think the clinical trial should be with chondroitinase alone (saturating the injury site with chonddroitinase ,etc) , or the combination of chondroitinase and graft , or should be both (half of the subjects get chondroitinase and the other half chondrotinase plus graft ,etc )?
    Thank you so much for working so hard in this research .
    This is really great and remarable that a well respected scientice/ researcher like you suggests that , it is time to take this research (chondroitinase plus graft ,etc) to clinical trial right now . YOU have a great weekend.
    Last edited by kz; 10-22-2011 at 12:21 PM.

  5. #95
    Senior Member kate's Avatar
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    Quote Originally Posted by soimumireland View Post
    What can we do, write to the company. Can Dr Silver give us some suggestions
    stay tuned . . . it takes a bit of doing to plan an effective and organized response.

  6. #96
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    Dr. J. Silver and W. Young. - Will clinical trials investigations’ as for cord blood mononuclear neuro throphine cells etc not be the best route in a clinical trial sci setting for chronics, and then why, why not so or, pls explain further Dr. Silver and Dr. Young. Thanks.
    Last edited by Leif; 10-22-2011 at 07:49 PM.

  7. #97
    Dr.Silver and Dr.Young should collaborate and make pressure to Acorda to give them full access to Chase. If community must be united, why not the scientist that work in the field?

    -Ramps in buildings are necessary, but it would be usefull to have another ones for people (mind/heart).....

    -Hoc non pereo habebo fortior me

  8. #98
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    -Hoc non pereo habebo fortior me

    I agree.


    But sci in the West live as long as ab ppl., so whom gives a shit.

    Last edited by Leif; 10-22-2011 at 11:16 PM.

  9. #99
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    The Western SCI doctrine is, do not try to help, moving 3-world as for sci, and not you (hey), because if so you are a clown. And if you try to move sci in the West we are super clowns. How lazy.

  10. #100
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    Ppl not in the boat, as for moving sci, - have never done it. Us the sci nead to fix things with proactive ppl. The rest (not focused) can go and hide. Bloddy hell, enough sci suffering.

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