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Thread: Minocycline - Any preliminary results

  1. #1

    Minocycline - Any preliminary results

    from tests being done in Vancouver U. on benefits for MS Patients? Has anyone seem any?

  2. #2
    Peter, I assume that you are referring to the report in April that minocycline may be useful for amyotrophic lateral sclerosis. Here is one of the latest links that I have been able to find on the subject http://www.alsbc.ca/research_updates.htm

    As you may know, even though it is an antibiotic, minocycline has strong anti-inflammatory effects and has been approved for treatment of arthritis.

    It is interesting that minocycline may be associated with some neurological problems http://www.pharmacyconnects.com/cont..._features.html

    Wise.

  3. #3

    Minocycline

    Sorry, Wise, it was actually a U. of Calgary MS Phase 1 Study initiated in part by the Dr. Ian Duncan's results w/ EAE animal model, at U. of Wisconsin.

    thanks,

    Peter

    Excerpt here:

    U of Calgary Study

    A small Phase I trial to investigate safety and dose tolerance to minocycline will also be conducted. It will involve 30 people with relapsing-remitting MS. This part of the study is being headed by Dr. Luanne Metz, associate professor at the University of Calgary, and director of the MS Clinic in Calgary. No additional details regarding the clinical trial are available at this time. It should be noted that some potential serious toxicity could occur with minocycline, even in doses used to treat acne. Also, the very long-term toxicity of minocycline is not known. Furthermore, little is known about the side effects that may occur in the doses that are being planned to treat people with MS. The initial trial with minocycline will be to address safety and tolerance issues.

  4. #4
    Senior Member Max's Avatar
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    Drug limits spinal cord damage

    Drug limits spinal cord damage
    Antibiotic reduces cell death in spinal injuries
    By William J. Cromie
    Harvard News Office

    A common antibiotic used to treat arthritis and acne shows promise for limiting the severity of spinal cord and brain injuries.

    When a fall, car crash, bullet, or knife crushes or cuts a spinal cord, the injury does not stop there. Rather, tissues continue to discharge toxic chemicals for hours, even days and weeks. These chemicals kill and disable nerve cells some distance away from the core injury, compounding the damage and making rehabilitation more difficult or impossible.

    Putting together clues about how brain and other nerve cells die, Yang (Ted) Teng and Robert Friedlander, Harvard Medical School neurosurgeons, decided to try to limit such the damage with an antibiotic called minocycline. Working with colleagues at Brigham and Women's Hospital and Children's Hospital, and the Veterans Administration in Boston, they gave rats injections of the drug one hour after spinal injuries that caused them to lose the use of their hind legs.

    http://www.news.harvard.edu/gazette/...pinalcord.html

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