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Thread: Miami Project

  1. #21
    This work has been several years in the making. The use of Schwann cell seeded bridges and Rolipram, a drug that increases cAMP, the intracellular signal of nerve growth factors, could not be reproduced in another lab as part of a NIH contract to reproduce interesting and potentially impactful studies (for the record, 10 of 11 "landmark" studies could not be reproduced in these NIH contracts to the best and brightest basic science SCI labs).


    It will be interesting to see if the FDA grants them approval for clinical trial as I don't think the work is ready for clinical translation (they don't know how any improvement in rat locomotion relates to "bridging the gap" of injury and, while they could not likely make thoracic complete injuries worse, they may, with their surgery, preclude recovery in these patients should another therapy come down the line that requires the original cord injury site be present). Better to see this go forward and have our SCI patients have a chance to participate in FDA approved, scientifically more rigorous studies than to have to fly overseas to spend money on stem cell voodoo elsewhere.

    I hope this actually has good results and FDA clinical trial approval so Dr. Barth Greene doesn't remain tethered to the rat labs the rest of his career.
    Last edited by c473s; 10-03-2011 at 08:35 PM. Reason: rat binder

  2. #22
    Quote Originally Posted by c473s View Post
    use of Schwann cell seeded bridges and Rolipram
    Is that the protocol that was submitted to the FDA?

  3. #23
    Senior Member lynnifer's Avatar
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    http://www.themiamiproject.org/Page.aspx?pid=339#SCI

    According to this chart, just the schwann cells. Rolipram research is ongoing. I remember that no lab could replicate the results that they so excited went to the media with back in 2004. (http://www.medscape.com/viewarticle/478917)
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  4. #24
    didnt wise project a phase 3 trial in china for late next year? so up to phase 3 in 2 years but miami project says 10-15?

  5. #25
    Senior Member Schmeky's Avatar
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    MP will drag this out as long as there are 2 dimes they rub together. If anyone really thinks differently, they must be smoking cr_ck.

  6. #26
    Senior Member Rollin Rick's Avatar
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    What blows my mind is that Marc and his father actually believe that their sweet Miami Project is fighting hard for a cure. While he is a full-blown quad, obviously comfortable living the way he is while multimillions of dollars are being pumped into the project while better and more promising things are happening elsewhere.... what's wrong with these people???
    A good friend is someone who will come to bail you out of jail. A TRUE friend is the guy sitting next to you behind the same set of bars saying, "boy we sure f*cked up this time huh?"

  7. #27
    Quote Originally Posted by rollin rick View Post
    what blows my mind is that marc and his father actually believe that their sweet miami project is fighting hard for a cure. While he is a full-blown quad, obviously comfortable living the way he is while multimillions of dollars are being pumped into the project while better and more promising things are happening elsewhere.... What's wrong with these people???
    bump !!!!
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  8. #28
    "When I say cure, it's relative," Green says. "For Marc it might be the ability to scratch his nose for the first time in 25 years."

    Well that will be useful - why have they raised over $350,000,000 and built that great empire if the returns are going to be so modest. Surely Marc Buoniconti isn't satisfied with that?

    And the schwann cell trial will reach the clinin in 10 to 15 years or more apparently - why so long?

  9. #29
    Dang, another Foundation not doing what they are suppossed to be doing. Last month it was the Rick Hansen Foundation. Who's next, Chris Reeve or ?

  10. #30
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    Quote Originally Posted by Patrick Madsen View Post
    Dang, another Foundation not doing what they are suppossed to be doing. Last month it was the Rick Hansen Foundation. Who's next, Chris Reeve or ?
    The next cure stunt towards might be the Patrick Madsen foundation. You seams to have a pond or two needed to move for some action.

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