Yes. Had relationship issue after rehab. Took a while, but Dr said my liver was stronger, not my depression worse, cranked anti-depressants (without a blood test) and then they eventually worked. He then did CBT which also worked and I stopped taking them under his supervision. Same Dr cranked dose of same drug, Doxepin on some one else and killed them. I also had them for pain later with bad effects such as inappropriate laughter, etc., but did nothing for regular pain and just made me evil. I like opioids for regular pain now.