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Thread: Spinal Cord Injury Articles Posted by Manouli

  1. #921
    Regenerative Medicine Restores Movement After Paralysis
    Twelve-month data from spinal cord injury trial shows two-thirds of subjects recovered two or more motor levels
    Article ID: 682409
    Released: 5-Oct-2017 4:05 PM EDT
    Newswise — Four of six people with paralyzing spinal cord injuries who were treated with a new cell therapy have recovered two or more motor levels on at least one side, new study results show.
    This 67 percent recovery rate is more than double the rates of recovery seen in both matched historical controls and published data in a similar population. Each of the six participants in the study had lost all motor function below the location of the spinal injury.

  2. #922
    September 15, 2017. BioAxone BioSciences, Inc. announced today that, as part of a collaborative effort with RXi Pharmaceuticals Corporation (NASDAQ: RXII), it is the recipient of a grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the agency’s SBIR Phase II funding program. This two-year grant provides funding for further development of BioAxone’s preclinical candidate BA-434, a novel sd-rxRNA compund that targets PTEN for the treatment of spinal cord injury. Read More.

  3. #923
    Tuesday, November 7, 2017
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    Be Thankful and Heal Faster: Author Describes Spinal Cord Injury Recovery
    Research projects at UCLA and elsewhere have proven that thankfulness (gratitude) has physical, in addition to emotional, effects on people. Shelly Kerchner, who just released her book Standing Tall: The Healing Power of Gratitude is an outstanding example.

    Johnstown, PA (PRWEB) November 02, 2017
    Shelly fell and fractured some vertebrae in her neck. Totally paralyzed, she heard the doctors saying “What a pretty girl. What a shame she’ll never get out of bed again.” Unfortunately, this is the experience of most newly-injured people, many of whom, though helpless, are suicidal after hearing that prognosis.
    Shelly was different. Going from depressed to determined, she told herself that paralysis was not going to keep her bedridden. She immediately gave thanks that she was still alive, and that she could hear and see. She made a habit of giving thanks for each little improvement. It was not easy – failure and discouragement were common. But by concentrating on controlling her thoughts, and staying thankful and positive, her recovery accelerated. After 10 years, she is still improving, driving a specially-equipped van, and now even walking with braces on her legs.

  4. #924
    Public Release: 6-Nov-2017
    New study finds widespread consequences after traumatic spinal cord injury
    Mary Ann Liebert, Inc./Genetic Engineering News

    New Rochelle, NY, Nov. 6, 2017--Researchers have shown that some of the critical pathophysiological responses to traumatic spinal cord injury (SCI), evidence of insufficient oxygen levels and metabolic stress that can permanently damage tissue, persist for at least a week post-injury at and extending away from the injury site in a large animal model. Evidence demonstrating hemodynamic and metabolic changes up to day 7 in a minipig model of traumatic SCI are reported in a new study published in Journal of Neurotrauma, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Journal of Neurotrauma website until December 6, 2017.


  5. #925
    Generating improvement in spinal cord injuries
    January 24, 2017 Rush University Medical Center
    A new therapy to treat spinal cord injuries in people who have lost all motor and sensory function below the injury site shows additional motor function improvement at 6-months and 9-months following treatment with 10 million AST-OPC1. The positive efficacy results from an ongoing research study were announced on Jan. 24 in a conference held by Asterias Biotherapeutics, Inc., the biotechnology company that manufactures AST-OPC1.
    "With these patients, we are seeing what we believe are meaningful improvements in their ability to use their arms, hands and fingers at six months and nine months following AST-OPC1 administration," said Dr. Richard G. Fessler, professor in the department of neurosurgery at Rush University Medical Center and lead investigator in the SCiStar Phase 1/2a study. Rush is one of six centers in the country currently studying this new approach.
    AST-OPC1 cells are made from embryonic stem cells by carefully converting them into oligodendrocyte progenitor cells, which are cells found in the brain and spinal cord that support the healthy functioning of nerve cells and can potentially make poorly functioning nerves function better.

  6. #926
    Immune cells help rebuild damaged nerves
    October 25, 2017
    Case Western Reserve University
    Immune cells are normally associated with fighting infection but in a new study, scientists have discovered how they also help the nervous system clear debris, clearing the way for nerve regeneration after injury. Researchers have recently shown certain immune cells -- neutrophils -- can clean up nerve debris, while previous models have attributed nerve cell damage control to other cells entirely.


  7. #927
    ReNetX Bio Receives $7M Commitment from Wings for Life to Bring Spinal Cord Treatment to Trial
    \l "\l "Share1 /news-release/2017/11/07/1176737/0/en/ReNetX-Bio-Receives-7M-Commitment-from-Wings-for-Life-to-Bring-Spinal-Cord-Treatment-to-Trial.html?print=1 /news-release/2017/11/07/1176737/0/en/ReNetX-Bio-Receives-7M-Commitment-from-Wings-for-Life-to-Bring-Spinal-Cord-Treatment-to-Trial.html?print=1
    November 07, 2017 13:00 ET | Source: ReNetx Bio

    NEW HAVEN, Conn., Nov. 07, 2017 (GLOBE NEWSWIRE) -- The Wings for Life foundation has made a significant commitment to ReNetX Bio, a New-Haven, Conn. based biotech startup that is advancing a cutting-edge therapy for chronic spinal cord injury to clinical trial. The foundation’s support is a testament to the promising research results from ReNetX Founder and Scientific Advisor Stephen Strittmatter, MD, PhD, Vincent Coates Professor of Neurology at Yale. His discovery of proteins which limit nerve fiber growth after injury, and subsequent development of a molecule to block receptors for these proteins, have formed the basis of a therapeutic that offers the first real hope to patients with chronic spinal cord injury.
    “Our mission is to find a cure for spinal cord injury,” says Jane Hsieh, Executive Director of the Wings for Life Accelerated Translational Program. “Dr. Strittmatter discovered and developed a molecule that blocks three different inhibitors, stabilizes the nervous system and allows for neuro-regeneration. This is a completely unmet need.”

  8. #928
    Stem cell treatment allows paraplegic rats to walk and regain sensory perception
    Download PDF Copy
    November 16, 2017
    Engineered tissue containing human stem cells has allowed paraplegic rats to walk independently and regain sensory perception. The implanted rats also show some degree of healing in their spinal cords. The research, published in Frontiers in Neuroscience, demonstrates the great potential of stem cells -- undifferentiated cells that can develop into numerous different types of cells -- to treat spinal cord injury.
    Spinal cord injuries often lead to paraplegia. Achieving substantial recovery following a complete spinal cord tear, or transection, is an as-yet unmet challenge.
    Led by Dr. Shulamit Levenberg, of the Technion-Israel Institute of Technology, the researchers implanted human stem cells into rats with a complete spinal cord transection. The stem cells, which were derived from the membrane lining of the mouth, were induced to differentiate into support cells that secrete factors for neural growth and survival.

  9. #929
    Here is the state of the science today for clinical paralysis reversal. The article comes with accompanying videos to illustrate what the procedures can accomplish

  10. #930

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