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Thread: Spinal Cord Injury Articles Posted by Manouli

  1. #911
    Leading Spinal Cord Injury Experts Join ReNetX Scientific Advisory Board


    NEW HAVEN, Conn., Oct. 10, 2017 (GLOBE NEWSWIRE) -- ReNetX Bio, a company developing first-in-class therapeutics to treat injury to the central nervous system, is expanding its Scientific Advisory Board with key opinion leaders specializing in spinal cord injury. Andrew Blight, PhD, brings experience as the former Chief Scientific Officer of Acorda Therapeutics, Inc., where he helped move forward therapies for stroke and spinal cord injury (SCI) and ran two of the largest multicenter clinical trials in chronic SCI around the potassium channel blocker, 4-aminopyridine, which achieved FDA approval for the treatment of walking impairment in persons with multiple sclerosis. Blight also brings significant academic research experience, particularly surrounding the role of inflammation and demyelination in SCI, and held faculty roles at New York University Medical Center, Purdue University and the University of North Carolina where he was Professor and Director of the Neurosurgery Research Laboratory.


  2. #912
    New approach helps rodents with spinal cord injury breathe on their own
    October 17, 2017
    One of the most severe consequences of spinal cord injury in the neck is losing the ability to control the diaphragm and breathe on one's own. Now, investigators show for the first time in laboratory models that two different sets of neural signals control the movement of the diaphragm—one that originates in the brain and one that starts in the spinal cord. The researchers used a drug to turn on this alternative nerve pathway and restore breath-like movements in rodents. The study appears October 17 in Cell Reports.
    "We realized that in order to further our research on how to direct nerve regeneration after spinal cord injury, we needed to first understand how this spinal activity arises," says first author Jared Cregg, a graduate student in neuroscience at Case Western Reserve University (CWRU) School of Medicine. "We took a basic approach to get at this question, which revealed the true nature of the mechanism."
    Rhythms in the nervous system are controlled by neural networks within the brain called central pattern generators. For breathing, the central pattern generator is located in the medulla region at the base of the skull. When the connection between the brain and the nerves that control the diaphragm is interrupted due to injury, the ability to breathe is lost.

  3. #913
    Science News
    from research organizations

    Discovery offers new hope to repair spinal cord injuries
    Scientists produce a type of stem cell-derived neuron that could potentially help restore movement
    April 24, 2017
    Gladstone Institutes
    Scientists have created a special type of neuron from human stem cells that could potentially repair spinal cord injuries. These cells, called V2a interneurons, transmit signals in the spinal cord to help control movement. When the researchers transplanted the cells into mouse spinal cords, the interneurons sprouted and integrated with existing cells.

  4. #914
    New surgical strategy offers hope for repairing spinal injuries
    July 28, 2017
    Repairing spinal injuries is a difficult business. Scientists previously developed a new surgical technique to reconnect sensory neurons to the spinal cord after traumatic spinal injuries. Now, they have gained new insight into how the technique works at a cellular level by recreating it in rats. The technique succeeds because offshoots from the spinal cord grow into the implanted sensory neurons to complete a spinal circuit.


  5. #915
    from research organizations

    Introduction of a novel system for in vitro analyses of zebrafish oligodendrocyte progenitor cells
    October 23, 2017
    Technische Universit?t Dresden
    Spinal cord injuries result from a blunt or penetrating trauma. This is generally caused by accidents that occur during sport activities or when driving. Injuries of the spinal cord can lead to extreme pain (e.g. pressure in the head, neck or back), the loss of sensation (e.g. in fingers or feet), the loss of control over different parts of the body, an abnormal sense of balance and many other symptoms. According to the World Health Organization (WHO), as many as 500,000 people suffer from spinal cord injuries each year. Humans do not regain spinal cord function after injury. However, zebrafish have the remarkable ability to functionally recover from spinal cord injury. They repair injured connections, replace damaged motor neurons and oligodendrocytes, enabling them to regain full movement within six weeks after injury.

  6. #916
    Science News

    Yale Scientist Aiming To Reverse Spinal Cord Injuries
    Rebecca LuryeContact Reporter
    NEW HAVEN — A Yale neurology and neuroscience professor who hopes to regrow neurons in patients with spinal cord injuries has secured enough funding for a human clinical trial.
    Stephen Strittmatter’s New Haven-based company, ReNetX, also has a new CEO, Erika Smith, who joined the biomedical venture in June after leaving her post as director of Yale University’s $10-million Blavatnik Fund for Innovation.
    The company has raised about $20 million from the National Institutes of Health and other sources to carry out the first stages of a trial involving people with tetraplegia, paralysis of all four limbs and the torso.
    Strittmatter said his approach works like a “double negative.” He identified a receptor that inhibits the growth of nerve fibers and then created a decoy to block it. That leaves the neurons free to grow — or regrow, in this case — naturally, as they do in early development.

  7. #917
    In partnership with the Perry Cross Spinal Research Foundation, the team at Griffith University’s Eskitis Institute for Drug Discovery is planning to undertake a clinical trial in 2018 to progress this journey and show that this therapy can further regenerate patients’ sensory and motor function.


  8. #918
    August 5, 2017 2:01 am JST
    Nipro closing in on stem cell cure for spinal cord injuries
    Japanese medical group to seek approval with eye toward 2018 launch
    OSAKA -- Medical equipment maker Nipro could commercialize next year a stem-cell-based treatment seen allowing people with spinal cord injuries to walk again.
    The Osaka-based company has carried out joint research with Sapporo Medical University since 2014. They recently found success in trials where stem cells harvested from bone marrow and increased are returned to the body, where they concentrate in injured areas of the spinal cord and regenerate tissue.

  9. #919
    Cellular mechanisms influencing corticospinal and sensory axonal regeneration into neural stem cell grafts after SCI
    Posted on October 28, 2017 by christalpowell
    Injured corticospinal tract axons regenerate robustly into caudalized neural progenitor cell (NPC) grafts and form functional synaptic connections with graft-derived neurons. However, the developmental fate of grafted NPCs, and whether those differentiated graft-derived neural subtypes might influence the regeneration of host axonal projections, remain unexplored. We demonstrate that upon maturation, embryonic spinal cord NPCs grafted into the injured, adult spinal cord contain clusters of dorsal spinal cord sensory interneurons that are potent zones of exclusion for regenerating corticospinal axons, but receive dense innervation by host CGRP+ sensory axons, reflecting the normal topographical projection patterns of these axons into distinct spinal cord laminae.

  10. #920
    Science News
    from research organizations

    Using donor stem cells to treat spinal cord injury
    Immune cells populating spinal cord after injury affect ability of stem cells to promote recovery
    August 28, 2017
    Society for Neuroscience
    A new study in mice details a potential therapeutic strategy that uses stem cells to promote recovery of motor activity after spinal cord injury.

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