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Thread: Spinal Cord Injury Articles Posted by Manouli

  1. #851
    November 19, 2015
    Athersys' MultiStem? Promotes Recovery After Acute Spinal Cord Injury in Preclinical Study
    Peer-Reviewed Study in Nature's Scientific Reports Demonstrates Stem Cell Therapy Promotes Improved Walking and Urinary Function
    CLEVELAND, Nov. 19, 2015 (GLOBE NEWSWIRE) -- Athersys, Inc. (Athersys) (NASDAQ:ATHX) announced today that multipotent adult progenitor cells (MAPC?), used in Athersys' MultiStem? cell therapy currently in clinical development, are effective in improving the health of animals after acute rodent spinal cord injury. Intravenous administration of MAPC one day after injury prevented loss of spinal cord tissue resulting in significant improvement of walking function and urinary control. These exciting new findings were published today in a peer-reviewed article in Nature's Scientific Reports
    Nervous system injuries, including spinal cord injury, traumatic brain injury and stroke, result in excessive inflammation, which is toxic to surrounding healthy tissue. Therefore, modulation of the immune system has long been an acute therapeutic target for neurological injury and disease. In this study, a single dose of MAPC was administered to rodents one day following severe spinal cord injury. Injured animals that received treatment demonstrated significantly improved voluntary control of bladder function, walking ability and preservation of at-risk nervous tissue. Further, the study defines a key mechanism of action of MAPC treatment, which occurs through the modulation of neuro-inflammation, including a significant reduction of inflammatory cell accumulation within the injury.

  2. #852
    Public Release: 23-Nov-2015
    Stem cell treatment mediates immune response to spinal cord injury in pre-clinical trials
    Treatment one day after injury is effective in preventing cascade of immune responses that often lead to loss of bodily functions
    Case Western Reserve University
    When a blunt-force blow injures the spinal cord, the body's immune system can be both friend and foe. Sensing the injury, the immune system dispatches an inflammatory response composed of specialized cells called macrophages to dispose of dead tissue. However, together with the debris and blood from the initial injury, the macrophages also clear away healthy tissue, resulting in a larger lesion size at the injury site and additional spinal cord injury loss of function.
    What if it were possible to reduce the size of the lesion in the spinal cord, thereby preserving more of the spinal cord and nerve function?

  3. #853
    November, 25 2015 17:00:00

    DA NANG — Da Nang General Hospital has agreed to conduct joint research on and treatment of spinal cord injuries in the Central and Central Highlands regions.
    The hospital will work in co-operation with Kinato Hospital in Osaka and the Foundation for Biomedical Research and Innovation from Japan.
    Director of the city's health department Ngo Thi Kim Yen confirmed to Viet Nam News that the agreement will focus on research and the application of stem cells in treating patients.

  4. #854
    (Science Daily via NewsPoints Desk)
    ⦁ Stem cell treatment mediates immune response to spinal cord injury in pre-clinical trials: Treatment one day after injury is effective in preventing cascade of immune responses that often lead to loss of bodily functions - (Science Daily via
    ⦁ Study results published in the journal Nature suggest that a family of therapeutic stem cells called multipotent adult progenitor cells (MAPC) could be used to lessen the consequences of the immune system's damaging effects during a spinal cord injury, Science Daily reported.
    ⦁ Researchers at Case Western Reserve University (CWRU) School of Medicine said the finding resulted in significant improvements in motor and urinary function in lab animals.

  5. #855
    Inspiring video captures the moment a biker 'paralysed' after breaking his back in a horrific crash defies doctors to stand up on his 30th birthday
    ⦁ Andrew Bell, 30, was told he would never walk again after the crash
    ⦁ Found a private clinic in Thailand offering specialist treatment
    ⦁ Began treatment - including having a chip put in his back - last month
    ⦁ Has now posted a video of himself standing up on his 30th video

    Madlen Davies for MailOnline
    Published: 05:52 EST, 11 December 2015 | Updated: 15:22 EST, 11 December 2015
    ⦁ A man told he'd never walk again after a motorbike accident has defied doctors to stand up on his 30th birthday - and celebrated by sending a moving video of it to his loved ones.
    ⦁ Andrew Bell was left wheelchair bound with a broken back following a horrific crash in May.
    The outlook was grave with doctors giving him the devastating news he would be paralysed for life -unable to walk down the aisle with girlfriend Helen or play with his nephew.
    His heartbreak soon turned to determination and he vowed to defy medics and stand up on the milestone birthday.
    He found a specialist clinic in Bangkok, Thailand, and flew there last month for pioneering treatment.
    Scroll down for video

  6. #856
    2015 World Stem Cell Summit Raises Hope: Scientists, Investors and Patient Advocates Spent Three Days Exploring Cures
    Genetics Policy Institute 4 hours ago GlobeNewswire
    ⦁ ATLANTA, Dec. 15, 2015 (GLOBE NEWSWIRE) -- The Genetics Policy Institute (GPI) and Regenerative Medicine Foundation (RMF) brought over a thousand scientists, clinicians, industry leaders, investors, government officials and patient advocates together for a three day conference designed to find cures and end human suffering at the 11th annual World Stem Cell Summit and the second annual RegMed Capital Conference, co-located at the Hyatt Regency in Atlanta, Georgia.

    "For 11 years, the Genetics Policy Institute has gathered leaders from the stem cell and regenerative medicine community to share the latest scientific discoveries, pathways to deliver treatments to patients, and how to accelerate investment in this lifesaving research," said Bernard Siegel, Founder of the World Stem Cell Summit & RegMed Capital Conference and Executive Director of GPI.


  7. #857
    Spinal Cord Injury-Global API Manufacturers, Marketed and Phase III Drugs Landscape, 2016
    ⦁ ID: 3534136
    ⦁ January 2016
    The Report, “Spinal Cord Injury-Global API Manufacturers, Marketed and Phase III Drugs Landscape, 2016”, provides comprehensive insights about the marketed drugs, drug sales, Phase III pipeline drugs and their API Manufacturersacross the globe. A key objective of the Spinal Cord Injury Report is to understand the market and pipeline status of the drugs around the Spinal Cord Injury to explore the generic development opportunities, licensing opportunities and to gain competitive advantage on designing pipeline startegies. The Report provides the historical and forecasted sales of the drugs till 2018. The Report gives insights into patents providing the patent protection data and marketing exclusivity of all the drugs across the Spinal Cord Injury. While the leading brands, companies and chemicals are considered thoroughly, the report also provides details on the Global API Manufacturers across the globe covering Drug Master Filings of US, Europe and API Manufacturers in Asia specifically China and India.

  8. #858
    Public Release: 22-Jan-2016
    UAB researchers find protein that improves mobility after spinal cord injuries
    Universitat Autonoma de Barcelona
    \l "\l "\l "\l "Share
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    IMAGE: Injured mouse spinal cord. view more
    Credit: UAB
    Spinal cord injuries cause severe functional disabilities in those who sustain them, including paraplegia or tetraplegia, depending on the scale of the injury. This is due to the degeneration of the spinal pathways that carry nerve signals from the brain to the different parts of the body and vice versa, resulting in loss of mobility and sensitivity underneath the injured area. Over the past few years, different studies have shown that the inflammatory response that develops after an injury contributes to the degeneration of these pathways, thus increasing the functional deficits brought by the injury. However, clinical trials using anti-inflammatory drugs like methylprednisolone have not proven their efficacy.

  9. #859
    Asterias Biotherapeutics : Receives Orphan Drug Designation for AST-OPC1 for the Treatment of Acute Spinal Cord Injury
    02/04/2016 | 07:01am US/Eastern

    FREMONT, Calif., Feb. 4, 2016 /PRNewswire/ -- Asterias Biotherapeutics, Inc. (NYSE MKT: AST), a biotechnology company focused on the emerging field of regenerative medicine, today announced receipt of Orphan Drug Designation from the U.S. Food and Drug Administration (FDA) for its product development candidate, AST-OPC1, for the treatment of acute spinal cord injury.
    Orphan Drug Designation is granted by the FDA Office of Orphan Products Development to products that treat rare diseases. The FDA defines rare diseases as those affecting fewer than 200,000 people in the United States. Orphan Drug Designation may provide the sponsor certain benefits and incentives, including a period of marketing exclusivity for the first marketing application if regulatory approval is received for the designated indication, potential tax credits for certain activities and waiver of certain administrative fees.


  10. #860
    'Bionic spine' could pave the way for new paralysis treatments

    Tuesday February 9 2016

    Assistive technology can improve the lives of people living with paralysis
    "'Bionic spine' could enable paralysed patients to walk using subconscious thought," reports The Guardian.
    In a study using sheep, Australian researchers have developed a device that can record movement signals from the brain. It's hoped this will eventually lead to these signals being transmitted to other parts of the body.
    The spine – specifically, the spinal cord – is essentially a signal cable. It transmits electrical impulses from the brain to other parts of the body. Damage to the spine can result in paralysis.
    Restoring this signal process in humans has been described as the "Holy Grail" of bionic medicine, which uses technology and engineering to improve or restore bodily functions.

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