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Thread: Spinal Cord Injury Articles Posted by Manouli

  1. #821
    Stem cell transplant may return sense of touch
    Big News Network (UPI) Monday 8th June, 2015

    UPSALLA, Sweden -- Spinal cord injury patients who have lost function and feeling to their arms and hands have been shown to regenerate nerve fibers that return the sense of touch through stem cell treatment.
    Spinal cord injuries often lead to paralysis, sensory loss and chronic pain conditions. Although surgery can restore certain muscle function, there has previously been little treatment available for lost sensory perception.


    http://www.bignewsnetwork.com/index.php/sid/233612969
    Last edited by manouli; 06-09-2015 at 05:01 PM.

  2. #822
    Quote Originally Posted by manouli View Post
    Stem cell transplant may return sense of touch
    Big News Network (UPI) Monday 8th June, 2015

    UPSALLA, Sweden -- Spinal cord injury patients who have lost function and feeling to their arms and hands have been shown to regenerate nerve fibers that return the sense of touch through stem cell treatment.
    Spinal cord injuries often lead to paralysis, sensory loss and chronic pain conditions. Although surgery can restore certain muscle function, there has previously been little treatment available for lost sensory perception.


    http://www.bignewsnetwork.com/index.php/sid/233612969
    In a new study the PhD students Jan Hoeber, Niclas K?nig and Carl Trolle, working in Dr.Elena Kozlova’s research group transplanted human stem cells to an avulsion injury in mice with the aim to restore a functional route for sensory information from peripheral tissues into the spinal cord.
    http://www.uu.se/en/media/news/artic...rtikel&lang=en
    Debating on CareCure is like participating in the special-olympics. You may win, but you're still disabled.

  3. #823
    With New Stretchy Spinal Implant, Science Has Taken Next Step Toward Helping
    Paralyzed Walk

    Scientists in Switzerland have created a thin, stretchy implant that can be applied to the surface of the spinal cord to administer electrical and chemical stimulation, potentially paving the way for science to restore lower body movement in humans.
    The e-Dura implant, made from silicon substrate embedded with electrodes, replicates the soft tissue around the spinal cord. Electrical and chemical stimulation has been adopted for studies using rats with spinal cord injuries. In a 2012 study, the same researchers showed that electrical-chemical stimulation could regain lower body use when a rat’s intelligence and regenerative capacity was awakened using a treatment of chemicals. Researchers found that the implant didn’t do any damage to the rat.
    However, applying this method to humans has been a bit more risky. Applying them to the spinal cord would cause the implant to rub, which would then cause inflammation and scar tissue. Ultimately, the implant would be rejected.
    read...
    http://www.medicaldaily.com/pulse/ne...medium=twitter

  4. #824
    Asterias Biotherapeutics Announces First Patient Treated in Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury
    By PR Newswire, June 08, 2015, 06:30:00 AM EDT
    Vote up
    A A A
    MENLO PARK, Calif., June 8, 2015 /PRNewswire/ -- Asterias Biotherapeutics, Inc. (NYSE MKT:AST), a biotechnology company focused on the emerging field of regenerative medicine, today announced that the first patient was successfully dosed at the Atlanta-based Shepherd Center in a Phase 1/2a clinical trial evaluating activity of escalating doses of AST-OPC1 (oligodendrocyte progenitor cells) in newly injured patients with sensory and motor complete cervical spinal cord injury (SCI). The Phase 1/2a trial is part of the planned registration program for AST-OPC1, with neurologically complete cervical SCI as the first targeted indication.


    Read more: http://www.nasdaq.com/press-release/...#ixzz3cy7oAsLs

  5. #825
    6/10/15 - InVivo Therapeutics Enrolls 3rd Patient in Pilot Spinal Cord Injury Trial [Professional Services Close - Up]

    InVivo Therapeutics Holdings Corp. (NVIV) reported that a third patient has been enrolled in the company's ongoing pilot trial of its investigational Neuro-Spinal Scaffold in patients with acute spinal cord injury at the Carolinas Medical Center, part of the Carolinas HealthCare System in Charlotte, NC.
    The company said that Dr. Dom Coric, of the Carolina Neurosurgery and Spine Associates and Chief of Neurosurgery at Carolinas Medical Center, together with Dr. William Bockenek, Chief Medical Officer at Carolinas Rehabilitation, are Co-Principal Investigators at this site. Dr. Coric along with Dr. Mark Smith of the Carolina Neurosurgery and Spine Associates, performed the third-ever Neuro- Spinal Scaffold implantation into an acute spinal cord injury patient. The implantation took place about three and a half days after the injury. Dr. Coric said, "The implantation procedure went smoothly and the patient is doing very well. It has been rewarding to be involved in this clinical study, and I look forward to following the patient's progress."
    read....
    http://www.pharmacychoice.com/News/a...cle_ID=1389375

  6. #826
    Researchers discovers ways to regenerate corticospinal tract axons

    Chronic spinal cord injury (SCI) is a formidable hurdle that prevents a large number of injured axons from crossing the lesion, particularly the corticospinal tract (CST). Patients inflicted with SCI would often suffer a loss of mobility, paralysis, and interferes with activities of daily life dramatically. While physical therapy and rehabilitation would help the patients to cope with the aftermath, axonal regrowth potential of injured neurons was thought to be intractable.
    No outside stimulants are needed; the growth driver lies within the neurons themselves.
    Inside our DNA, in particular.
    more....
    http://medicalxpress.com/news/2015-0...act-axons.html

  7. #827
    InVivo Therapeutics Reports Significant Improvement Of Second And Third Patients Implanted With Neuro-Spinal Scaffold
    ⦁ Therapeutics Reports Significant Improvement Of Second And Third Patients Implanted With Neuro-Spinal Scaffold&via=TheStreethttp://www.linkedin.com/shareArticle?mini=true&url=http://www.thestreet.com/story/13208110/1/invivo-therapeutics-reports-significant-improvement-of-second-and-third-patients-implanted-with-
    InVivo Therapeutics Holdings Corp. (NVIV) today announced a one-month post-implant update for the third study patient and a six-month post-implant update for the second study patient in the company's ongoing pilot trial of its investigational Neuro-Spinal Scaffold in patients with complete acute spinal cord injury.
    read...

    http://finance.yahoo.com/news/invivo...t-improvement-

  8. #828
    Findings identify receptors modulating macrophage responses to spinal cord injury
    July 10, 2015 | by Editor


    Macrophages are cellular sentinels in the body, assigned to identify "attacks" from viruses, bacteria, or fungi and sound the alarm when they are present. However, these cells are a "double edged sword" in spinal cord injury, providing both neural repair-promoting properties and pathological functions that destroy neuronal tissue "We know from previous research that macrophages are versatile, and signals at the injury site can stimulate repair or destruction--or confusingly, both," said John Gensel Ph.D., Assistant Professor of Physiology in the Spinal Cord and Brain Injury Research Center at the University of Kentucky. "But the mechanisms through which these signals stimulate the good and/or bad functions in macrophages are not known. So the next big question to answer in the efforts to understand and treat SCI was, 'Why?'" - See more at: http://www.neuroscientistnews.com/re....aMgu3VfP.dpuf

  9. #829
    Toyota Helps Paralyzed Veteran Open Spinal Cord Injury Recovery Center
    Toyota Provides Last-Mile Support to Innovative Facility
    Submitted by: Toyota Motor North America
    Categories:Philanthropy & Corporate Contributions, Health & Wellness
    Posted: Jul 17, 2015 – 03:30 PM EST
    TAMPA, Fla., Jul. 17 /CSRwire/ - During his third tour of duty in Afghanistan, Romy Camargo’s patrol was ambushed. A sniper’s bullet changed the life of this decorated war veteran and his family. Now, with help from Toyota, Camargo, his family and a strong team of supporters are forever changing the lives of paraplegics and quadriplegics across the country.
    Camargo and his wife, Gaby, have opened the doors to Stay In Step, a new, non-profit recovery center dedicated to helping spinal-cord injury (SCI) patients take a step forward toward recovery. This groundbreaking facility offers treatment, rehabilitation and support services to veterans and civilians in Tampa, Fla.
    read....
    http://www.csrwire.com/press_release...ecovery-Center

  10. #830
    The Race To Treat Spinal Cord Injury: A Comparative Analysis
    Jul. 16, 2015 10:23 AM ET | 13 comments | About: InVivo Therapeutics Holdings Corp (NVIV), Includes: AST, CUR, STEM
    Disclosure: I am/we are long NVIV. (More...)
    Summary
    ⦁ Four biotech companies are pursuing the treatment of spinal cord injury with the use of stem cell transplantation.
    ⦁ Each company demonstrated efficacy in pre-clinical studies.
    ⦁ The race is in the early stages but InVivo Therapeutics is clearly leading the pack based on its strategic approach to accelerated HDE approval and initial trial results.
    There are four small biotech companies vying to develop a new standard of care for spinal cord injury; InVivo Therapeutics (NASDAQ:NVIV), StemCells, Inc. (NASDAQ:STEM), Neuralstem, Inc (NASDAQ:CUR) and Asterias Biotherapeutics (NYSEMKT:AST). All four companies use some form of stem cell therapy as part of its overall therapeutic platform. What follows is a comparative analysis of each company.
    read....
    http://seekingalpha.com/article/3330...ative-analysis

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