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Thread: Spinal Cord Injury Articles Posted by Manouli

  1. #601
    New device offers hope to patients with spinal cord injuries
    May 30, 2013 7:21 PM |

    This monthly column explores ideas, insights and discoveries made in New Jersey that are shaping our future.

    The body has extraordinary self-healing capabilities, and one New Jersey researcher is building on nature’s regenerative powers with the development of a new delivery system designed to increase the effectiveness and safety of stem cell therapy for spinal cord injuries (SCI) and other regenerative medicine applications.

    The StemCell Bag™ is a new method for reintroducing healthy adult stem cells into the body to regenerate spinal nerves in patients with SCI often caused by severe traumas from car accidents and sports injuries.

    Using adult stem cells which are derived from the patient’s own body, as opposed to the more controversial embryonic stem cells, which are developed in vitro, Dr. Hatem Sabaawy, M.D., Ph.D., founder of Celvive is delighted with the results of clinical trials conducted on patients in an international study.

    “The outcome has been amazing. Many of the patients were confined to their beds and wheel chairs, unable to walk. As a result of the treatment, one out of two patients regained sensation and improved motor improvement and were able to regain mobility,” said Sabaawy, assistant professor of medicine in the division of medical oncology at UMDNJ-Robert Wood Johnson Medical School and the Cancer Institute of New Jersey in New Brunswick.

    He said the overall response rate that was 23 out of 50 or 46 percent of the patients showed neurological improvements, and many of the 23 patients were able to walk with canes.


  2. #602
    Study on Rats Shows Promise of Spinal Cord Injury Repair

    Mark Whittington, Yahoo! Contributor Network
    Jun 2, 2013 "Share your voice on Yahoo! websites. Start Here."

    SciTech reports that a study conducted by a team of researchers at the University of California, San Diego School of Medicine holds out the promise for the repair of spinal injuries, giving hope to people who are paralyzed due to the traumatic injury.

    According to National Spinal Cord Injury Statistical Center, roughly 12,000 people per year suffer a spinal cord injury and survive in the United States. Somewhere between 236,000 to 370,000 people in the United States have some form of spinal injury.

    The Mayo Clinic reports that spinal cord injury can result


  3. #603
    Neuronal regeneration and the two-part design of nerves

    Published on Jun 04, 2013
    Contact Laura J. Williams, (734) 615-4862, (734) 834-6801 (cell),

    ANN ARBOR—Researchers at the University of Michigan have evidence that a single gene controls both halves of nerve cells, and their research demonstrates the need to consider that design in the development of new treatments for regeneration of nerve cells.
    A paper published online in PLOS Biology by U-M Life Sciences Institute faculty member Bing Ye and colleagues shows that manipulating genes of the fruit fly Drosophila to promote the growth of one part of the neuron simultaneously stunts the growth of the other part.

    Understanding this bimodal nature of neurons is important for researchers developing therapies for spinal cord injury, neurodegeneration and other nervous system diseases, Ye said.

    Nerve cells look strikingly like trees, with a crown of "branches" converging at a "trunk." The branches, called dendrites, input information from other neurons into the nerve cell. The trunk, or axon, transmits the signal to the next cell.

    "If you want to regenerate an axon to repair an injury, you have to take care of the other end, too," said Ye, assistant professor in the Department of Cell and Developmental Biology at the U-M Medical School.


  4. #604
    Published: 05 June 2013
    Blocking a protein could be key to treating spinal cord injuries

    Queensland scientists will begin clinical trials of treatment for spinal cord injuries after discovering dramatic improvements in balance and coordination when blocking a protein.

    Researchers at the Queensland Brain Institute (QBI), the Queensland Institute of Medical Research (QIMR), and the University of Melbourne showed that blocking protein EphA4 could rapidly restore the balance and limb coordination of models with spinal injuries.

    QBI Director and study co-leader, Professor Perry Bartlett said the research confirmed and expanded on previous studies showing that blocking the action of this protein receptor prevented the loss of nerve tissue following injury and promoted repair.

    Professor Bartlett and QIMR Professor Andrew Boyd identified the role of EphA4 in 1998.

    They showed that the EphA4 protein was critical to the development of the nerves which control walking and other complex muscle functions.

    Subsequent studies showed that after a spinal cord injury, the production of the EphA4 protein was increased and this protein acted to stop severed nerve endings from regrowing through the injury site.

    Professor Boyd's laboratory at QIMR, working with Professor Bartlett's lab at UQ, then developed a “decoy” protein, to block, or inhibit EphA4 function.


  5. #605
    Senior Member Imight's Avatar
    Join Date
    Nov 2007
    Quote Originally Posted by manouli View Post
    Imight hi, please don't lose your hope. As long we are alive, there is hope. Many companies, as you read now, are doing trials and they are very optimistic with their results. I know it seems it takes for ever, and probably is true but I feel it's getting better because they do their trials with humans now, it will give them clear view what is working and what is not. I just turn 60 years old, and I know before I die the cure will be here and I'll die standing up. Life without of hope is not worth of living. Keep your eyes open and read what is going on so you won't miss anything new, and if you can help to speed it up do so. The other day, I was watching the news and they were talking about stem cell results trials on spinal cord, and it was good news. Please forgive me, I don't try to tell you what to do and how to feel, but you just asked me how I feel, now you know. We only have one life to live, and got unlucky, it does not mean that we always be unlucky for the rest of our lives, might good things are coming to us, soon, now, later. I truly hope so!

    be well, manouli.
    thanks for giving me hope manouli.

  6. #606
    Well said Manouli, thanks for everything you have done

  7. #607
    June 11, 2013
    Hope for spinal cord injuries: Coaxing damaged nerve cells to grow, send messages to the brain again
    by Jacqueline Mitchell

    "An ailment not to be treated," read the prescription for a spinal cord injury on an Egyptian papyrus in 1,700 B.C. Not much has changed in the intervening millennia. Despite decades of research, modern medicine has made little headway in its quest to reverse damage to the central nervous system.

    That is not to say, however, that there isn't a glimmer of hope. Laura Wong, an M.D./Ph.D. student in Professor Eric Frank's molecular physiology lab at the Sackler School, has been able to coax damaged nerve cells known as sensory neurons to regenerate, growing as much as 10 times longer than previously documented. What's more, the new neurons make organized connections with their counterparts inside the spinal cord and brain stem, ensuring information from the outside world paints an accurate picture inside the brain.

    "All the regeneration in the world isn't going to make any difference if they don't reconnect. You're still not going to get any function," says Wong, who has worked since 2010 in Frank's lab, which is trying to develop therapies for spinal cord injuries.

    Her findings, which she presented at the annual meeting of the Society for Neuroscience in 2011 and 2012, shed light on the complex processes behind nerve cell growth and regeneration. If those results can be replicated in patients, it could prevent certain types of nerve damage and improve quality of life for some.

    Going the distance


  8. #608
    Testing method promising for spinal cord injuries, multiple sclerosis

    Created on Thursday, 13 June 2013 12:00
    Written by Emil Venere

    West Lafayette, Indiana - A medical test previously developed to measure a toxin found in tobacco smokers has been adapted to measure the same toxin in people suffering from spinal cord injuries and multiple sclerosis, offering a potential tool to reduce symptoms.

    The toxin, called acrolein, is produced in the body after nerve cells are injured, triggering a cascade of biochemical events thought to worsen the injury's severity. Acrolein also may play an important role in multiple sclerosis and other conditions.

    Because drugs already exist to reduce the concentration of acrolein in the body, being able to detect and measure it non-invasively represents a potential treatment advance, said Riyi Shi, a professor of neuroscience and biomedical engineering in Purdue University's Department of Basic Medical Sciences, School of Veterinary Medicine, Center for Paralysis Research and Weldon School of Biomedical Engineering.

    "If the acrolein level is high it needs to be reduced, and we already have effective acrolein removers to do so," Shi said. "Reducing or removing acrolein may lessen the severity of symptoms in people who have nerve damage, but there has not been a practical way to monitor acrolein levels in nervous system trauma and diseases."


  9. #609
    Christopher and Dana left behind great kids, like the parents like son.

    Christopher Reeve’s son: ‘A cure for paralysis will be available within our lifetime’

    Superman actor's death in 2004 won't stop Matthew Reeve's fight to fund research into spinal injuries. As 'Man of Steel' hits theaters, he hopes attention will help his father's off-screen legacy as well.
    By Ethan Sacks / NEW YORK DAILY NEWS
    Friday, June 14, 2013, 9:43 AM
    The medical leap may not come in a single bound, but legendary Superman actor Christopher Reeve’s son believes there will come a day when paralysis will be cured.

    “A cure for spinal injuries will be available within our lifetime — and it is a question of when, not if,” the 33-year-old Matthew Reeve told Britain’s Sun newspaper.

    Last edited by manouli; 06-17-2013 at 02:40 PM. Reason: better link

  10. #610
    Senior Member
    Join Date
    Jun 2008
    The research articles posted here give me hope that therapy/surgery to restore function (and reduce pain) to those of us with spinal cord injuries (including chronic sci) is on the way...I really hope this happens soon.
    C4/5 incomplete, 17 years since injury

    "The trick is in what one emphasizes. We either make ourselves miserable, or we make ourselves happy. The amount of work is the same.” - Carlos Castaneda

    "We live not alone but chained to a creature of a different kingdom: our body." - Marcel Proust

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